Waitlist priority, quality donors tied to better outcomes in pediatric acute liver failure

Over three decades, changes to organ allocation policies were associated with reduced waitlist mortality and increased rates of liver transplant among children with pediatric acute liver failure, according to research in JAMA Surgery.
“Pediatric acute liver failure is a rapidly progressive disease that occurs in otherwise healthy children,” Juliet Emamaullee, MD, PhD, FRCS, FACS, study author and research director in the division of abdominal organ transplantation at Children’s Hospital Los Angeles, told Healio. “Up to 25% will require emergency liver transplant. How

Dementia more frequently diagnosed in older adults within a year of fall-related injury

Falling was associated with an increased risk for a diagnosis of Alzheimer’s disease or other dementias in older adults, according to a recent analysis in JAMA Network Open.
Falls are the leading cause of injury among adults aged 65 years and older, with one in four older adults — over 14 million — reporting falling annually, according to the CDC.
“We want to understand why falls happen, and also what care older adults need to maximize their quality of life after a fall,” Molly Jarman, PhD, MPH, an assistant professor of surgery at Harvard University, told Healio.

VIDEO: Sozinibercept combination therapy shows promising visual acuity gains in wet AMD

BARCELONA, Spain — In this Healio Video Perspective from the Euretina congress, Timothy L. Jackson, PhD, MBChB, discusses phase 2b trial results of sozinibercept for neovascular age-related macular degeneration.
Sozinibercept (Opthea) targets VEGF-C and VEGF-D and is meant to be used in combination with the VEGF-A-suppressing drugs ranibizumab or aflibercept. In the trial, two different doses of sozinibercept were used in combination with ranibizumab and showed superior efficacy with the higher dose as compared with ranibizumab monotherapy.
“It was exciting to see a drug that was

Study: People older than 65, unvaccinated most likely to be hospitalized with COVID-19

Most people in the United States hospitalized with COVID-19 are likely to be aged older than 65 years or have not been vaccinated, according to a study.
“Hospitalization due to COVID-19 has remained a public health concern since the start of the COVID-19 pandemic,” Christopher A. Taylor, PhD, epidemiologist in the Coronavirus and Other Respiratory Viruses Division in the CDC’s National Center for Immunization and Respiratory Diseases, and colleagues wrote in the study, published in MMWR.
“Persons of all ages remain at risk for COVID-19-associated hospitalization. Among

GLP-1RA use linked to 19% reduction in risk for glaucoma in type 2 diabetes

Use of glucagon-like peptide-1 receptor agonists was associated with a 19% reduction in risk for glaucoma in patients with type 2 diabetes, with longer use extending the protective association, according to a study in Ophthalmology.
“Glucagon-like peptide-1 receptor agonists (GLP-1RAs), commonly prescribed for the management of type 2 diabetes and obesity, recently have gained attention for their role in facilitating retinal neuroprotection, which may prevent glaucoma development and progression,” Siar Niazi, MD, of the department of cardiology at North Zealand Hospital in Denmark,

What providers should know about changes to substance use confidentiality regulations

On Feb. 16, HHS, through its Office for Civil Rights and Substance Abuse and Mental Health Services Administration, published its final rule amending federal regulations protecting confidentiality of substance use disorder treatment records.
The final rule modified 42 Code of Federal Regulations Part 2 to align certain aspects of the regulations with HIPAA and the Health Information Technology for Economic and Clinical Health (HITECH) Act.
The Part 2 amendments aim to increase coordination among providers, strengthen the confidentiality of Part 2 records through enforcement, and improve health

Zyno Medical recalls select IV infusion pumps due to risk for air bubbles

Zyno Medical is recalling select Z800 infusion pumps due to a defect in the air-in-line software algorithm that may allow a 1 mL air bubble to be passed on to a patient, according to the FDA.
The use of the affected product may cause serious adverse health consequences, including vascular air embolism, tachyarrhythmia, myocardial infarction, stroke, seizure and death. There have been two reported injuries and no reports of death, the FDA said in a press release.
According to the release, Zyno Medical Z800 infusion systems are intended to provide IV nutrition or parenteral fluids, blood and

FDA approves Hympavzi for hemophilia A or B without inhibitors

The FDA approved marstacimab-hncq for treatment of certain individuals with hemophilia.
The indication applies to routine prophylaxis to prevent or reduce frequency of bleeding episodes among adults or children aged 12 years or older who have hemophilia A without factor FVIII inhibitors. The indication also applies to use of the agent for people with hemophilia B without factor IX inhibitors.
Marstacimab-hncq (Hympavzi, Pfizer) is the first anti-tissue factor pathway inhibitor approved in the United States for treatment of hemophilia A or B, according to a Pfizer press release. It is

Q&A: Are COVID-19, vaccine hesitance to blame for pertussis spike in US?

The number of pertussis cases in the United States has quadrupled over the last 12 months, according to the CDC, raising questions as to what is behind the sudden, significant spike.
The CDC reports 17,579 cases of pertussis in 2024 as of Oct. 5, compared with 3,962 reported cases through the same date in 2023 — a nearly fivefold increase year over year — which the agency said is higher than was seen in 2019, before the COVID-19 pandemic.
In addition to outbreaks in the U.S., pertussis cases have also increased this year in Brazil, Mexico and Peru amid declines in vaccination