Mpox spread around the globe in 2022, popping up in 110 countries — including 103 that had not historically reported the disease, according to CDC tracking.
There were more than 83,000 reported cases globally as of Dec. 21, with nearly 30,000 of those cases occurring in the United States.
By the time U.S officials declared it a public health emergency, cases were climbing by as many as 2,000 per week. As public health agencies adapted to the outbreaks, fractional doses of the vaccines and vast outreach efforts stemmed the tide of new cases.
Below is a timeline of the global outbreak using