Researchers led by Azusa Inoue at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered a gene responsible for prenatal death when critical transgenerational instructions are missing from egg cells. Published April 28 in Genes & Development, the study shows that in mice, failed epigenetic suppression of an X-chromosome gene called Xist leads to miscarriage and developmental abnormalities.
An epigenetic cause of miscarriages is identified and cured in mice
Researchers led by Azusa Inoue at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered a gene responsible for prenatal death when critical transgenerational instructions are missing from egg cells. Published April 28 in Genes & Development, the study shows that in mice, failed epigenetic suppression of an X-chromosome gene called Xist leads to miscarriage and developmental abnormalities.