Patients with Lennox-Gastaut syndrome experienced a significant reduction in drop seizures with fenfluramine, according to results of a clinical trial published in JAMA Neurology.
“Most patients with [Lennox-Gastaut syndrome (LGS)] develop between three and five seizure types that wax and wane during disease progression,” Kelly G. Knupp, MD, MSCS, a neurologist at Children’s Hospital Colorado, and colleagues wrote. “Convulsive seizures (e.g., generalized tonic-clonic seizures) are also commonly observed and usually occur in later stages of LGS but sometimes may precede