Gene variant may impede sublingual immunotherapy for Japanese cedar allergies

Researchers have associated a variant of the HLA-DPB1 gene with poor responsiveness to sublingual immunotherapy for Japanese cedar pollinosis, according to a study published in Allergy.
“Our results suggest that patients carrying at least one HLA-DPB1*05:01 allele have an increased risk of being nonresponders to SLIT (sublingual immunotherapy),” Shigeharu Fujieda, MD, PhD, of the division of otorhinolaryngology, head and neck surgery at University of Fukui in Matsuoka, Japan, said in a press release.
“This implies that differences in the antigen-binding pocket on the HLA-DPB1

Researchers have associated a variant of the HLA-DPB1 gene with poor responsiveness to sublingual immunotherapy for Japanese cedar pollinosis, according to a study published in Allergy.
“Our results suggest that patients carrying at least one HLA-DPB1*05:01 allele have an increased risk of being nonresponders to SLIT (sublingual immunotherapy),” Shigeharu Fujieda, MD, PhD, of the division of otorhinolaryngology, head and neck surgery at University of Fukui in Matsuoka, Japan, said in a press release.
“This implies that differences in the antigen-binding pocket on the HLA-DPB1