There was insufficient evidence of excess harm associated with off-label IV thrombolysis in patients after ischemic stroke with recent intake of a direct oral anticoagulant, researchers reported in JAMA Neurology.
Currently, international guidance recommends avoiding IV thrombolysis in patients with ischemic stroke who have recently taken a direct oral anticoagulant, Thomas R. Meinel, MD, of the Stroke Research Center at the University of Bern in Switzerland, and colleagues wrote.
Meinel and colleagues sought to determine whether the risk for symptomatic intracranial hemorrhage was associated