Investigating protein signature changes during heart disease caused by reductive stress

Two years ago, University of Alabama at Birmingham researchers and colleagues reported that reductive stress—an imbalance in the normal oxidation/reduction, or redox, homeostasis—caused pathological changes associated with heart failure in a mouse model. This was a follow-up to their 2018 clinical study that found about one in six heart failure patients shows reductive stress.
Two years ago, University of Alabama at Birmingham researchers and colleagues reported that reductive stress—an imbalance in the normal oxidation/reduction, or redox, homeostasis—caused pathological changes associated with heart failure in a mouse model. This was a follow-up to their 2018 clinical study that found about one in six heart failure patients shows reductive stress.