Itaconate and its derivative 4-octyl itaconate inhibit the Januse kinase 1 immune protein, which has implications for potential severe asthma treatment, according to a study published in Cell Metabolism.
“My lab is interested in the metabolite itaconate and derivatives based on it, which have a range of anti-inflammatory effects,” Luke A.J. O’Neill, PhD, chair of biochemistry at the Trinity College Dublin School of Biochemistry and Immunology, told Healio.
“M2 macrophages, which are involved in asthma pathogenesis, can take up itaconate, and so we wondered what effect it