Belief updating was more optimistic and depression decreased as soon as 4 hours after initial ketamine infusion in those with treatment-resistant depression compared with healthy controls, per a study published in JAMA Network Open.
“Pharmacological studies on healthy participants have shown that ketamine disturbs the belief-updating process by changing the way participants update their beliefs when faced with new information,” Hugo Bottemanne, MD, of the Paris Brain Institute at Sorbonne University in Paris, and colleagues wrote. “Moreover, another study on [major depressive