Large genome-wide study finds ‘dozens’ of new causal genes, pathways in gout

PHILADELPHIA — Researchers have identified “dozens” of new causal genes and pathways responsible for disease activity in patients with gout, according to a presenter at ACR Convergence 2022.
“We have had urate genome-wide association studies revealing over 200 loci controlling serum urate levels and these are dominated by molecular control of renal and gut excretion of urate,” Tony Merriman, PhD, of the University of Alabama at Birmingham, told attendees. “Our hypothesis goes that there are unidentified genes in the human genome that are involved in

PHILADELPHIA — Researchers have identified “dozens” of new causal genes and pathways responsible for disease activity in patients with gout, according to a presenter at ACR Convergence 2022.
“We have had urate genome-wide association studies revealing over 200 loci controlling serum urate levels and these are dominated by molecular control of renal and gut excretion of urate,” Tony Merriman, PhD, of the University of Alabama at Birmingham, told attendees. “Our hypothesis goes that there are unidentified genes in the human genome that are involved in