Long-term supplementation with spermidine improved neither memory function nor biomarkers compared with placebo in older adults with subjective cognitive decline, according to results of a clinical trial published in JAMA Network Open.
“Maintenance of cognitive function and brain health are of utmost importance in an aging society with an increase in age-related diseases, such as Alzheimer’s disease,” Claudia Schwarz, PhD, of the department of neurology at Charité University Medicine Berlin, and colleagues wrote.
Schwarz and fellow researchers sought to determine the