Opinion: Men and women may respond differently to vaccines. Research needs to account for that

Tackling possible sex differences in the effects of new drugs and vaccines in humans should begin early on, in Petri dishes and animal studies.

Two days after getting my second dose of the Moderna mRNA vaccine as part of a clinical trial, my body was still mounting a robust immune response when, from the floor of my son’s bathroom, I frantically telephoned the clinical research site at the University of Illinois.

The region of my brain that controls thermoregulation, the hypothalamus, likely detected the flood of vaccine-induced copies of viral proteins in my bloodstream and cranked up my internal thermostat to 104.7 degrees F, a fever high enough to make me feel delirious. The trial’s principal investigator called in a prescription for an anti-nausea medication and two bags of IV fluid, which a mobile service gave me at home to stabilize me.

Read the rest…