Organoids reveal the tipping point when kidney damage turns irreversible

Where is the tipping point between reversible kidney damage and chronic disease? A new study using miniature kidney models sheds light on that crucial juncture.

Chronic kidney disease is a serious medical problem that changes the lives of about 13% of the world’s population. Some kidney damage is reversible; kidney cells can marshal their repair mechanisms to heal harm caused by high blood pressure, diabetes, or harsh medications like chemotherapy. But some damage can become permanent, limiting people’s lives as their kidneys lose their ability to filter blood and remove the body’s waste products.

Just where the tipping point sits between injury that is fixable and damage that’s beyond repair hasn’t been clear.

Read the rest…