High polygenic risk score in individuals with early or suspected glaucoma was associated with a faster rate of peripapillary retinal nerve fiber layer thinning and visual field worsening, a study found.
“This raises the possibility that when combined with other clinical risk factors, a glaucoma PRS may be a valuable adjunct in determining treatment thresholds and intensity and the onset and frequency of glaucoma surveillance,” the authors wrote.
The study included 1,103 genotyped participants from the Progression Risk of Glaucoma: Relevant SNPs With Significant Association study.