Acral melanoma is a rare subtype that represents roughly 3% of all melanoma cases. Unlike typical melanoma that occurs on sun-exposed skin, acral melanoma develops on the nonhair bearing skin of the soles, palm and nail beds. There is very little information known about the development of acral melanoma. But in a new article published in Clinical Cancer Research, researchers from Moffitt Cancer Center’s Donald A. Adam Melanoma and Skin Cancer Center of Excellence reveal key differences in the cellular and molecular composition of acral melanoma compared to melanoma. Their findings may lead to new potential therapeutic targets for this rare disease.