Metastatic or leptomeningeal disease (LMD), the spreading of a brain cancer to the meninges, is a devastating cancer complication that does not respond well to conventional therapies. While researchers can directly inoculate some brain tumors with an engineered virus that selectively targets cancer cells, this invasive technique is not feasible for widespread or surgically inaccessible malignancies, such as in LMD.
Safety and efficacy of intraventicular immunovirotherapy with oncolytic HSV-1 for CNS cancers
Metastatic or leptomeningeal disease (LMD), the spreading of a brain cancer to the meninges, is a devastating cancer complication that does not respond well to conventional therapies. While researchers can directly inoculate some brain tumors with an engineered virus that selectively targets cancer cells, this invasive technique is not feasible for widespread or surgically inaccessible malignancies, such as in LMD.