A systematic review and meta-analysis of randomized control trials (RCTs) found that sodium-glucose cotransporter-2 (SGLT2) inhibitors reduce hospitalizations and may reduce cardiovascular deaths among people experiencing heart failure regardless of the presence of diabetes. These findings support existing guidelines that recommend SGLT2 inhibitors for preventing incident and worsening heart failure in people with type 2 diabetes, heart failure, or both. The authors caution that treatment with SGLT2 inhibitors should be balanced against the potential harms of increased genital infections. The analysis is published in Annals of Internal Medicine.
SGLT2 inhibitors reduces hospitalization for heart failure regardless of presence of diabetes
A systematic review and meta-analysis of randomized control trials (RCTs) found that sodium-glucose cotransporter-2 (SGLT2) inhibitors reduce hospitalizations and may reduce cardiovascular deaths among people experiencing heart failure regardless of the presence of diabetes. These findings support existing guidelines that recommend SGLT2 inhibitors for preventing incident and worsening heart failure in people with type 2 diabetes, heart failure, or both. The authors caution that treatment with SGLT2 inhibitors should be balanced against the potential harms of increased genital infections. The analysis is published in Annals of Internal Medicine.