
A large study conducted in five African countries identified an easier and less toxic treatment for HIV-associated cryptococcal meningitis that includes a single high dose of liposomal amphotericin B.
Experts said the regimen will simplify treatment guidelines and could improve outcomes in areas with a high burden of the disease.
Joseph N. Jarvis, MRCP, PhD, a researcher from the London School of Hygiene & Tropical Medicine, and colleagues from the Ambition Study Group conducted the phase 3 randomized controlled noninferiority trial at eight hospitals in Botswana, Malawi, South Africa,