Trastuzumab deruxtecan shows ‘terrific activity’ in second line for breast cancer subset

Trastuzumab deruxtecan reduced risk for disease progression or death compared with trastuzumab emtansine among patients with HER2-positive metastatic breast cancer previously treated with trastuzumab and a taxane.
Results of the multicenter, open-label, randomized phase 3 DESTINY-Breast03 trial, published in The New England Journal of Medicine, also showed an association of trastuzumab deruxtecan (Enhertu; AstraZeneca, Daiichi Sankyo) with adjudicated interstitial lung disease and pneumonitis, although researchers reported numerically lower incidence than in previous trials.
“The activity

Trastuzumab deruxtecan reduced risk for disease progression or death compared with trastuzumab emtansine among patients with HER2-positive metastatic breast cancer previously treated with trastuzumab and a taxane.
Results of the multicenter, open-label, randomized phase 3 DESTINY-Breast03 trial, published in The New England Journal of Medicine, also showed an association of trastuzumab deruxtecan (Enhertu; AstraZeneca, Daiichi Sankyo) with adjudicated interstitial lung disease and pneumonitis, although researchers reported numerically lower incidence than in previous trials.
“The activity