Use of oxycodone with fluoxetine or paroxetine increases risk for opioid overdose

Patients who started oxycodone while taking fluoxetine or paroxetine were at increased risk for opioid overdose compared with those who were taking other selective serotonin reuptake inhibitors, a cohort study showed.
According to Ismaeel Yunusa, PharmD, PhD, an assistant professor in the department of clinical pharmacy and outcomes sciences at the University of South Carolina College of Pharmacy, and colleagues, the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and paroxetine are “potent inhibitors” that metabolize oxycodone through the cytochrome-P450 2D6 (CYP2D6)

Patients who started oxycodone while taking fluoxetine or paroxetine were at increased risk for opioid overdose compared with those who were taking other selective serotonin reuptake inhibitors, a cohort study showed.
According to Ismaeel Yunusa, PharmD, PhD, an assistant professor in the department of clinical pharmacy and outcomes sciences at the University of South Carolina College of Pharmacy, and colleagues, the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and paroxetine are “potent inhibitors” that metabolize oxycodone through the cytochrome-P450 2D6 (CYP2D6)