In a noninferiority randomized trial, the antidepressants amitriptyline and venlafaxine significantly reduced the number of migraine attacks per month, according to researchers.
Although the treatment benefits were statistically similar, adverse events such as dry mouth, constipation, sleepiness, weight gain and fatigue were reported more frequently in patients with migraine who received amitriptyline. For this reason, “venlafaxine could have priority over amitriptyline in migraine prophylaxis,” Mohaddeseh Hedayat, PharmD, a faculty member in the department of pharmacology and