VEXAS syndrome ‘more common than expected’

VEXAS syndrome is “more common than expected” in both men and women, with one in 13,591 individuals demonstrating a UBA1 disease-causing variant, according to data published in JAMA.
“In our JAMA paper, to understand how common VEXAS is, and the full spectrum of medical problems associated with it, we inverted this approach and used the ‘genome first’ ascertainment strategy,” Douglas R. Stewart, MD, of the division of cancer epidemiology and genetics at the National Cancer Institute, in Maryland, told Healio. “This means we identified patients based on

VEXAS syndrome is “more common than expected” in both men and women, with one in 13,591 individuals demonstrating a UBA1 disease-causing variant, according to data published in JAMA.
“In our JAMA paper, to understand how common VEXAS is, and the full spectrum of medical problems associated with it, we inverted this approach and used the ‘genome first’ ascertainment strategy,” Douglas R. Stewart, MD, of the division of cancer epidemiology and genetics at the National Cancer Institute, in Maryland, told Healio. “This means we identified patients based on