Viscosupplementation linked with less pain, more adverse events in patients with knee OA

Compared with placebo, viscosupplementation provided a small reduction in pain but increased risk of serious adverse events in patients with knee osteoarthritis, according to published results.
Using MEDLINE, EMBASE and CENTRAL databases, researchers performed a systematic review of 169 randomized trials that compared outcomes of intra-articular injections of hyaluronic derivatives, also known as viscosupplementation, with either a placebo or no intervention for 21,163 patients with knee OA. Median follow-up after the last injection was 13 weeks, according to the study. Outcomes included pain

Compared with placebo, viscosupplementation provided a small reduction in pain but increased risk of serious adverse events in patients with knee osteoarthritis, according to published results.
Using MEDLINE, EMBASE and CENTRAL databases, researchers performed a systematic review of 169 randomized trials that compared outcomes of intra-articular injections of hyaluronic derivatives, also known as viscosupplementation, with either a placebo or no intervention for 21,163 patients with knee OA. Median follow-up after the last injection was 13 weeks, according to the study. Outcomes included pain