Senate committee considers Casey Means, MD, for surgeon general

Lawmakers grilled Casey Means, MD, on vaccines, AI, conflicts of interest and more during Wednesday’s Senate hearing to be the next surgeon general.
Means, nominated by the Trump administration, was initially set to appear before the U.S. Senate Committee on Health, Education, Labor and Pensions (HELP) in October, but it was postponed when she went into labor hours before the hearing.
She has been a controversial pick for the nation’s doctor, where she would be tasked with “providing Americans with the best scientific information available on how to improve their health and reduce the risk of

Hope for gonorrhea vaccine wanes after failed trial

DENVER — In 2017, researchers in New Zealand published the first evidence that a vaccine might be able to prevent gonorrhea, a wily STI that has confounded scientists with it ability to dodge just about every drug used to treat it.
The surprising discovery was made when the researchers realized that a vaccine developed to combat an epidemic of meningitis B in New Zealand also seemed to have an impact on gonorrhea rates.
The finding was met with enthusiasm, invigorating gonorrhea vaccine research and spawning numerous studies, including an NIH-funded trial that is still underway and several

NTX-1024 IND application for vernal keratoconjunctivitis cleared

The FDA cleared an investigational new drug application for NTX-1024 ophthalmic solution in vernal keratoconjunctivitis, paving the way for a phase 2/3 clinical trial, according to a press release from NexEos Bio.
A randomized, double-masked, vehicle-controlled trial that will test the safety and efficacy of the eye drop is planned to begin later this year, according to the release.
According to NexEos, NTX-1024 neutralizes the eosinophil cationic protein-mediated inflammation that is involved in vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis.
“To our knowledge, NTX-1024 is

FDA approves encorafenib combination for metastatic colorectal cancer

The FDA has approved the first combination, targeted regimen for previously untreated BRAF V600E mutation-positive metastatic colorectal cancer.
Encorafenib (Braftovi, Pfizer) plus cetuximab (Erbitux, Eli Lilly & Co.) and fluorouracil-based chemotherapy received approval for adult patients with metastatic colorectal cancer with a BRAF V600E mutation detected by an FDA-authorized test, according to an FDA press release.
This encorafenib-led combination previously received accelerated approval in December 2024.
The FDA based its latest decision on the randomized phase 3 BREAKWATER trial, which

Pterygium excision technique does not require glue, sutures

WAIKOLOA, Hawaii — A surgical technique for pterygium excision that does not use glue or sutures yielded safety, efficacy and cost-effectiveness, according to a study published in Ophthalmology and Therapy.
The retrospective analysis included 34 eyes of 33 patients, with the aim of investigating whether a surgical technique using DefEYE’s Biovance 3L Ocular, a triple-layer dehydrated, decellularized amniotic basement membrane tissue, and short exposure to mitomycin C could reduce recurrence and complications after pterygium surgery. Before surgery, 88.2% of eyes had primary pterygia and 11.8%

New HIV infections would soar if Ryan White program went away

DENVER — Melissa Schnure, PhD, wants to make sure some of the country’s most vulnerable patients are protected — low-income people living with HIV who depend on federally funded HIV services.
It is why Schnure, a senior epidemiologist at the Johns Hopkins University School of Medicine, and her team spent countless hours with other researchers conducting a simulation study that analyzed the impact of a worst-case scenario for HIV in the United States: the elimination of the Ryan White HIV/AIDS Program, the largest federally funded program dedicated to providing primary medical care and

Depression diagnosis linked to kidney disease progression

A depression diagnosis may contribute to kidney disease progression for adults with chronic kidney disease, according to study data published in Frontiers in Nephrology.
Depression has been linked to poor outcomes for adults with advanced stage CKD, with depression rates ranging from 20% to 40% for these populations, according to Mohammad A. Al-Mamun, PhD, assistant professor of health services and outcomes research at West Virginia University School of Pharmacy, and colleagues. However, little is known about the effects of depression on earlier stages of CKD, they wrote.
“Understanding the

FDA clears PCR test that detects 11 gastrointestinal pathogens

The FDA has cleared a multiplex polymerase chain reaction test designed to detect 11 clinically relevant gastrointestinal pathogens from a single stool sample.
The Xpert GI Panel (Cepheid) can identify eight diarrhea-causing bacteria, two parasites and one virus in just over an hour, which Cepheid Chief Medical Officer Connie Savor, MD, said is a much-needed innovation for clinicians and patients alike.
“It covers the most likely causes of somebody who has acquired diarrhea outside of the hospital,” Savor told Healio.
The current process for testing diarrheal syndromes uses conventional

Cardiovascular disease and CV risk factors to rise in women

Cardiovascular disease and CV risk factors among women are expected to increase through 2050, with predicted increases in hypertension, obesity and diabetes, researchers reported.
The prevalence of hypertension, diabetes, smoking, poor diet and inadequate physical activity is predicted to remain stable among younger girls, but researchers predict a significant increase in obesity, according to a scientific statement published in Circulation.
“One in every three women will die from cardiovascular disease — maybe it’s your grandmother, or your mother or your daughter,” Karen E. Joynt Maddox, MD,