NEW ORLEANS — Patients with a BMI of 30 kg/m2 or greater who underwent medial patellofemoral reconstruction had similar complication rates to patients with a BMI less than 30 kg/m2, according to results presented here.
“BMI is a useful screening tool, but it is an imperfect measure of obesity and most physicians recognize its limitations,” Elizabeth R. Dennis, MD, MS, FAAOS, assistant professor in the department of orthopedics at Icahn School of Medicine at Mount Sinai Hospital, told Healio about results presented at the American Academy of Orthopaedic Surgeons Annual Meeting. “While BMI is

HELSINKI — The EndoArt artificial endothelial layer showed positive results across multiple studies presented by specialists at the European Society of Cataract and Refractive Surgeons winter meeting.
“It looks like a contact lens, only you put it inside the eye and not on top of the cornea,” Ruth Lapid, MD, PhD, said.
Made of hydrophilic acrylic material, EndoArt (EyeYon Medical) adheres to the posterior surface of the cornea, acting as a barrier to the transfer of fluids. It is designed to treat chronic corneal edema in complex cases and serves as an alternative to human corneal

Knee osteoarthritis is one of the leading causes of disability in the United States and worldwide.
Patients who have failed conservative treatments but are not ready or indicated for knee replacement are a challenging population to treat, especially in individuals with high activity demands.
Source: Seth L. Sherman, MD
Traditional surgical options such as unicompartmental knee arthroplasty may require activity modification and carry a risk for early revision or conversion to total knee arthroplasty. High tibial osteotomy presents concerns regarding surgical morbidity, osseous healing and

Wearing orthokeratology lenses to control myopia progression may pose risks to ocular surface health, including loss of meibomian glands and tear film instability, according to a study published in Contact Lens & Anterior Eye.
“Contact lenses have several advantages, but they act as foreign bodies on the eye and can alter the normal structure of the tear film,” Xiao-Di Yang, of First Affiliated Hospital of Zhengzhou University, China, and colleagues wrote. “[Orthokeratology] lenses are corneal contact lenses worn overnight. ... Several studies have examined their effects

CHICAGO — A combination of surveillance, enhanced cleaning and relocating colonized patients was the formula for ending a nearly 3-year-long Candida auris outbreak in a pediatric ICU in South Korea.
In a poster presentation at SHEA Spring, Hye-Jin Ki, RN, BSN, detailed how staff at Yonsei University College of Medicine’s Severance Hospital ended a 34-month C. auris outbreak in the 10-bed PICU.
From January 2023 through June 2025, clinicians identified 28 C. auris isolates from 27 patients in the pediatric ICU, all of which were resistant to fluconazole and amphotericin B.
Most of the isolates (n

Higher consumption of ultraprocessed foods may lower fertility in men and women and slow human development, according to two recently published analyses.
The findings “are compelling, particularly because they move beyond maternal diet alone and consider both partners,” Leigh A. Frame, PhD, MHS, an associate professor at The George Washington University, told Healio.
Frame, who was not involved in either study, said that while they do not indicate that ultraprocessed foods (UPFs) alone determine fertility outcomes, they build upon “a growing body of evidence that diet quality,

COPENHAGEN, Denmark — In this Healio video, Alissa J. Cooper, MD, a thoracic oncologist at Dana-Farber Cancer Institute, discusses the first-in-human phase 1 study of setidegrasib in non-small cell lung cancer with KRAS G12D mutation.
Setidegrasib (ASP3082, Astellas Pharma), a novel protein degrader that targets KRAS G12D mutations, showed promising early results, Cooper said.
“There was a progression free survival of about 8 months in all patients and about 11 months in the second- or third-line setting, which is very good and very promising, especially for a pretreated patient,” she said.

COPENHAGEN, Denmark — In this Healio video, Alissa J. Cooper, MD, a thoracic oncologist at Dana-Farber Cancer Institute, discusses the Beamion LUNG-1 trial evaluating zongertinib in HER2-mutant advanced non-small cell lung cancer.
The phase 1b trial included treatment-naive patients with HER2 tyrosine kinase domain mutations who received 120 mg zongertinib (Hernexeos, Boehringer Ingelheim) as first-line therapy once daily.
“This had a really exciting response rate of 77%, disease control rate of 96%, with only 1% of patients with primary progression, which is super exciting,”

An international consensus group has endorsed formal definitions for atopic dermatitis disease activity and remission, part of an effort to standardize clinical trial design and shift toward a treat-to-target approach.
The definitions, established through a modified Delphi consensus initiative led by the International Eczema Council (IEC), integrated clinician-assessed signs with patient-reported symptoms. Of the changes, the most notable was a switch from the use of “on-drug remission” to “on-drug complete control,” according to Joseph F. Merola, MD, MMSc, FAAD, professor and chair of the

There are some topics that are so central to the experiences of both doctors and patients that they deserve an annual review.
For example, every September for as many years as I can remember, I have offered an update on all things anti-inflammatory in dry eye disease (DED). Believe it or not, if you add in the appearance of generics, insurance company shenanigans and the annual incredulous shock suffered by D.C. politicians when their collective backsides get nipped by the unforeseen consequences of their oddly named bills, I may never run out of stuff to say there.
Especially if Brent Saunders