Researchers at the Fralin Biomedical Research Institute at VTC have identified a natural protective protein that maintains healthy lung blood vessels. Increasing the expression of this protein in preclinical models of pulmonary arterial hypertension reversed key features of the disease, including pulmonary vascular remodeling and heart dysfunction.

Researchers at Tel Aviv University have presented new findings indicating that the experimental drug Davunetide may significantly slow the progression of progressive supranuclear palsy (PSP) in women, who exhibited a markedly different response to treatment than men. These results reinforce the need for sex-specific medicine in neurodegenerative diseases.

Ancient mummy DNA recovered in Chile has yielded the firmest evidence yet that European colonization brought smallpox to the Americas.

Major depressive disorder, commonly referred to as depression, is a debilitating psychiatric disorder estimated to affect roughly 5% of the global population. Depression is characterized by persistent sadness and hopelessness, difficulty concentrating on tasks, a lack of interest in everyday activities and changes in sleep and/or appetite.

REM sleep is already called "paradoxical sleep." The body is largely still, yet the brain is highly active. In humans, this is also the stage most closely associated with vivid dreaming. Our study, published in Communications Biology, has revealed another paradox hidden within REM sleep: Brain blood volume increased, but the ATP available inside neurons decreased.

Researchers at the MRC Laboratory of Medical Sciences (LMS), Imperial College London and UCL Genetics Institute have created a detailed map of cells within breast tumors and identified distinct neighborhoods of proliferating and dormant cells. The study, published in Genome Medicine, reveals that protective immune and connective cells surround the hibernating cancer cells, potentially shielding them from treatments. It suggests future therapies may need to target not only different cancer cell states but also the local environments that help them survive, to both halt tumor growth and prevent cancer from coming back later.

Hutchinson–Gilford progeria syndrome (HGPS) is a genetic disorder that causes remarkable premature aging. Most patients die during their teenage years from cardiovascular disease, but the precise mechanisms underlying vascular damage remain unclear.

A new path has opened toward stopping cancer-associated cachexia, a devastating complication that gradually wastes patients away. A KAIST research team has developed an RNA-based therapeutic strategy that blocks a brain signal to prevent muscle loss and extend survival.

In a promising sign for the potential of focused sound waves to improve care for brain tumors, UVA Health researchers have determined that tumors called gliomas may be even more receptive to targeted drug delivery than normal brain tissue.

The Ebola outbreak in the Democratic Republic of Congo is intensifying at an "exceptional" pace, the World Health Organization warned on Saturday, calling for a significant scaling up of the health response.