Drug allergy delabeling rare for children with primary immunodeficiency

PHILADELPHIA — Children with primary immunodeficiencies often had drug allergy labels, almost all of which were not confirmed when evaluated, according to data reported at the American Academy of Allergy, Asthma & Immunology Annual Meeting.
These children frequently receive antibiotics for prophylactic use and for active infections, Christine Rukasin, MD, FAAAAI, allergist and clinical immunologist, Phoenix Children’s, and colleagues wrote.
But due to these allergy labels, the researchers continued, children with drug allergy labels often use second-line antibiotics with broader spectrums,

Benefits of a virtual asthma self-management education program

PHILADELPHIA — More than 75% of adults in a virtual asthma self-management education program had improved asthma control afterward, according to data presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting.
“I hope the findings will encourage clinicians who experience time constraints, to provide asthma self-management education to patients with uncontrolled asthma as a collaborative bridge for asthma self-management education,” Leandra Tonweber, PA-C, AE-C, lead disease management coach at Allergy & Asthma Network (AAN), told Healio. “The Virtual Asthma

Developing a human hepatocyte model with enhanced drug-metabolizing enzyme activity

A research team led by Associate Professor Shinpei Yamaguchi and the late Professor Masako Tada of the Faculty of Science, together with Professor Yojiro Anzai and Lecturer Yohei Iizaka of the Faculty of Pharmaceutical Sciences at Toho University, have developed a new HepaRG cell line with markedly enhanced activity of CYP2D6, a major drug-metabolizing enzyme. This engineered human hepatocyte model enables more human-relevant evaluation of drug-induced hepatotoxicity mediated by CYP2D6. The study was published in the journal PLOS ONE on December 29, 2025.

One-question screen may flag hoarding in Alzheimer’s and other dementias

Researchers at the University of Colorado Anschutz have developed a simple, one-question screening tool that could help doctors quickly identify hoarding behaviors in patients with memory loss and other brain disorders. Early detection, they said, could lead to early intervention, helping to reduce safety risks, relieve caregiver stress and improve the quality of life for both patients and families.