Rare MGRN1 gene variant tied to fetal heart malformations

The Human Genetics Research Group of the University of Tartu Faculty of Medicine has identified a gene whose defect may cause congenital heart malformations in the fetus. The MGRN1 gene has not previously been associated with early human development or with any disease. The discovery will help doctors better recognize similar cases in the future and improve the counseling and treatment offered to affected families.

Irregular bedtime linked to higher risk of cardiac events

An irregular bedtime in midlife may signal an increased risk of cardiovascular disease. A new study from the University of Oulu suggests that large swings in when people go to bed could double the risk of serious cardiac events—particularly among those who get less than eight hours of sleep.

SARS-CoV-2 delta and omicron BA.2 show clustered spike D614 reversions. What it could mean for surveillance

Researchers from University of Tsukuba and Institute of Science Tokyo have identified nonrandom patterns in the emergence of spike D614 reversions in publicly available SARS-CoV-2 genomic data. Analysis of publicly available sequences revealed numerous instances in which the spike D614G substitution, previously associated with increased transmissibility, reverted from G614 to the ancestral D614 residue, with these events predominantly occurring in the delta and omicron BA.2 lineages. The detected reversions also exhibited nonrandom patterns in temporal occurrence and geographic distribution.

Stress tested, testing stress: Novel organoid models how the adrenal gland develops

Sitting above each kidney are two small endocrine glands about the size of walnuts. These are the adrenal glands, responsible for producing hormones that help control some of the body's most critical functions. Among these hormones, cortisol is particularly critical for survival. Often referred to as the "stress hormone," it helps the body adapt to a wide range of challenges—both emotional and physical, such as trauma or infection—by regulating overall metabolism. Despite its central role in stress and endocrine biology, how the adrenal gland is built and how it functions remains poorly understood.

Smart sensor decodes fatigue and stress from body signals on the move

About one in three employees in Singapore report feeling burnt out—one of the highest rates globally. Burnout and chronic fatigue carry a substantial economic cost and pose serious risks in professions where alertness is critical. Yet diagnosing fatigue and related mental health conditions today relies largely on self-reported questionnaires, which tend to be subjective, intermittent, and poorly suited to real-time evaluation.

Longer weekly home-visit rehabilitations linked to improved activities of daily living in older adults

In aging societies, the role of home-visit rehabilitation (HR)—which provides physical, occupational, and speech therapy in patients' homes—is becoming increasingly important for supporting independent living. Although previous studies have shown that HR can help maintain and improve activities of daily living (ADL) among older adults with limited access to outpatient services, the dose-response relationship between the amount of HR time per week and ADL improvement remains unclear.