How Low-Level Light Exposure Influences Cellular Repair Mechanisms

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Light has always been known for providing us with visual clarity. However, in living organisms, specific types of light can cause cells to respond in a measurable way. Photobiomodulation is a term that developed in the last 20 years after several researches have demonstrated that light at low power densities can find its way to […]

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Integrative Medicine in Modern Healthcare: What Does the Research Say?

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Decentering the “Primary Care Is a Place” Paradigm: A Bridge to Whole-Person Care Healthcare is evolving. In recent years patients and providers alike have questioned whether treating symptoms alone is sufficient. Integrative medicine has arisen to address this transition, providing a model in which conventional medical treatments and evidence-based complementary therapies can coexist. Instead of treating itself as […]

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Chronic Venous Insufficiency: Emerging Research and Modern Treatment Approaches

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Chronic Venous Insufficiency (CVI) is a very widespread, but largely underestimated vascular disorder that involves millions of people throughout the world. Defined by inability of the venous system in lower extremities to bring blood back toward the heart CVI occurs when the vein valves weaken, allowing reflux and accumulation of blood in legs. Chronic venous disease: as […]

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Chronic spontaneous urticaria response to barzolvolimab persists 24 weeks after treatment

PHILADELPHIA — Patients with chronic spontaneous urticaria had positive outcomes weeks after barzolvolimab, according to data presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting.
These findings suggest that treatment with barzolvolimab may modify disease, Martin Metz, MD, head of translational research, Charité University Medicine, Berlin, and colleagues wrote.
“Barzolvolimab is a humanized monoclonal antibody with a completely novel mechanism of action that uniquely targets the root cause of CSU — the mast cell,” Diane Young, MD, senior vice president and chief

Tapinarof cream improves sleep in pediatric atopic dermatitis

PHILADELPHIA — Among patients aged 2 to 17 years with moderate to severe atopic dermatitis, tapinarof cream 1% significantly improved sleep, according to data presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting.
“In my clinical experience, severe itching and sleep disruption are especially burdensome for patients with AD, so these data have the potential of being particularly impactful,” Druhan L. Howell, MD, adjunct professor and pediatrics program director in the department of internal medicine at the University of South Alabama, told Healio.
In a sub-analysis

FDA OKs new pediatric indications for once-weekly growth hormone

The FDA has approved three new pediatric indications for somapacitan-beco, a once-weekly, long-acting growth hormone injection, according to a press release issued by Novo Nordisk.
Somapacitan-beco (Sogroya, Novo Nordisk) is now approved for children aged 2.5 years and older with idiopathic short stature, short stature born small for gestational age and no catch-up growth by age 2, and growth failure associated with Noonan syndrome, according to the release.
Somapacitan-beco was previously approved for adults with growth hormone deficiency and children aged 2.5 years and older with growth

Studies support single-tablet HIV regimen vs. common, complex regimens

DENVER — Data from two studies presented at the Conference on Retroviruses and Opportunistic Infections support the use of a novel, single-tablet HIV regimen vs. standard, more complex treatment options.
Researchers presented data from two phase 3 trials:
“Single-tablet regimens have long been recognized as critical to optimizing HIV treatment, with convenient dosing supporting better adherence and improved clinical outcomes,” Eric G. Meissner, MD, PhD, associate professor of medicine and director of HIV and hepatitis patient care and research at the Medical University of South Carolina and

In 25 years as an emergency doctor, I saw patients say ‘thank you’ in these 6 ways

An elderly patient came to the ED after slipping on the ice. I knew her ankle was broken since the lower extremity was swollen and deformed.
Nonetheless, she smiled, her energy was appreciative, and she thanked me each time I circled back and updated her. At discharge, I handed her the paperwork, smiled and said, “cool shoes.” Months later, I noticed a package in my hospital mail slot: she sent a similar pair of shoes with a thank-you note.
As an emergency medicine and lifestyle medicine doctor, I practice and speak about the health benefits of gratitude, or being thankful and appreciative,

Pritelivir shows promise against HSV in immunocompromised patients

DENVER — Pritelivir, an investigational antiviral drug for herpes simplex virus, demonstrated “superior efficacy” in healing lesions in immunocompromised patients, according to results of a phase 3 trial.
The study, which included 101 immunocompromised participants with refractory or resistant HSV, showed that 62.7% of patients taking pritelivir (Aicuris) experienced lesion healing compared with 34% in the control group for a treatment difference of 28.7 percentage points (95% CI, 8%-47.1%).
Jean-Michel Molina, MD, PhD, a French physician and researcher who presented the study at the Conference

3D bioprinted corneal implants may ease donor tissue shortage

In an ongoing phase 1 clinical trial, a patient who was recognized as legally blind was implanted with a 3D bioprinted corneal implant.
According to a press release from Precise Bio, the implant, known as PB-001, is manufactured using a robotic 3D biofabrication system, with the aim of improving visual outcomes, lowering complication rates and providing a solution for the global corneal tissue shortage. The implantation of PB-001 marked the world’s first transplant of a cell-based, functional 3D bioprinted cornea, the release said.
“This achievement marks a turning point for regenerative