Children with amblyopia who used the AmblyoPlay app 5 days a week for 6 months had significant improvements in visual acuity, as well as oculomotor function and motor coordination, according to data published in BMC Ophthalmology.
“These findings reinforce our core belief that amblyopia treatment must go beyond visual acuity,” Matic Vogri, CEO of Smart Optometry, the maker of AmblyoPlay, told Healio. “Vision is a complex, interconnected system, and AmblyoPlay is designed to train multiple visual skills — not just one.”
AmblyoPlay is an app intended to treat amblyopia through dichoptic therapy,

Early-onset preeclampsia was associated with increased risk for delayed early-childhood development in the domain of problem-solving among preterm children, researchers reported.
Although other domains of child development were affected by hypertensive disorders of pregnancy (HDP) and its subtypes, the relationships were not statistically significant, according to data published in JAMA Network Open.
Geng Chen, MMSc, of the Graduate School of Medicine at Tohoku University in Sendai, Japan, and colleagues evaluated the association of HDP and developmental patterns in children using data from the

The FDA has issued a complete response letter for an oral selective glucocorticoid receptor antagonist under investigation for the treatment of hypertension secondary to hypercortisolism, according to an industry press release.
Corcept Therapeutics announced the FDA issued a complete response letter for relacorilant (Corcept Therapeutics). The drug is under investigation for the treatment of endogenous hypercortisolism, ovarian cancer and other disorders, according to the company.
As Healio previously reported, the phase 3 GRACE trial enrolled 152 adults with Cushing’s syndrome plus

Pinhole pupilloplasty is a surgical procedure that aims to narrow the pupil to pinhole size to impart greater depth of focus and neutralize associated higher-order aberrations.
Following pinhole pupilloplasty (PPP), patients usually experience satisfactory vision under photopic and mesopic light condition, as documented in our series (Narang et al.). Recently, we encountered a few patients who experienced visual difficulty in poor illumination or during twilight or nighttime conditions. Under normal circumstances, the pupil dilates when dim illumination is encountered. However, after PPP, the

New guidelines for blood-based biomarkers, the impact of hormone replacement therapy, and risks for cognitive decline with red meat consumption were among the top Alzheimer’s disease and other cognitive impairment stories for 2025.
Leading off Healio’s in-depth coverage of GLP-1s across the medical field, experts from the Alzheimer’s Association, Harvard Medical School and other stakeholders weighed in on the potential of GLP-1s to address psychiatric symptoms such as eating disorders, depression and addiction. The consensus was that more clinical trials on the direct and indirect effects of

New guidelines for blood-based biomarkers, the impact of hormone replacement therapy and risks for cognitive decline with red meat consumption were among Healio’s top Alzheimer’s disease and other cognitive impairment stories for 2025.
Blood-based biomarker testing can be used as part of an Alzheimer’s disease diagnosis in specialty care settings but must have sensitivity and specificity greater than 90% to be used as the sole diagnosis (confirmatory) method. We spoke with Sheena Aurora, MD, vice president of medical affairs at the Alzheimer’s Association, to find out more. Read more.
The

Healio Pulmonology has compiled the top news on smoking and vaping posted in 2025.
Readers were most interested in varenicline for vaping abstinence in teenagers and young adults; the impact of paternal smoking during puberty on epigenetic age acceleration in offspring; the global burden of secondhand smoke exposure among children; the impact of exclusive e-cigarette use on the risk for COPD, type 2 diabetes and heart failure; and the risk for COPD among adults who identified as regular cigarette smokers before age 15 years.
Here are Healio’s top 10 most-read stories on smoking and vaping from

In 2025, the most-read Healio story on skin disorders was about the impact dietary diversity during pregnancy has on the risk for atopic dermatitis in offspring.
Other popular stories focused on rezpegaldesleukin (Nektar Therapeutics) for AD and the difference in mortality between adults with chronic spontaneous urticaria and adults without this condition.
Check out the list below for the top skin disorder stories Healio posted in 2025.
Consuming a diverse diet during pregnancy may reduce the risk for AD in offspring by changing the infant gut microbiome, according to results published in

As the year comes to a close, Healio is pleased to present our most widely read hematology and oncology content from the past year.
We hope you enjoy this look back at what you and your colleagues considered some of the most compelling research breakthroughs and treatment advances in 2025.
The addition of high-dose IV vitamin C to standard chemotherapy nearly doubled OS for patients with advanced pancreatic cancer, according to results of a randomized phase 2 trial. Read more.
Many Black and Latina women frequently use lotions, soaps, shampoos and other personal care products that contain the

Exposure to occupational inhalants such as silica, pesticides, asbestos, solvents, fertilizers, animal dust and engine exhaust may increase the risk for rheumatoid arthritis, according to data published in Arthritis & Rheumatology.
“In research on etiology of an autoimmune disease, we need to investigate the relationships between genes, environment and immunity,” Lars Klareskog, PhD, senior professor of rheumatology at Karolinska Institutet in Stockholm, Sweden, told Healio. “The analyses of these multiple potential risk factors revealed that airborne exposures were, by