Doctors “Pleased and Impressed” By results of Lipedema Liposuction Clinical Trial

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German plastic surgeons report that liposuction is an effective way to reduce pain caused by Lipedema. Not only did patients experience a decrease in pain scale scores post surgery, these decreases were larger than those described by participants who tried complex decongestive therapy.

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AAOS urges change to Medicare Physician Fee Schedule proposed rule

In a press release, the American Academy of Orthopaedic Surgeons urged CMS to withdraw the proposed policies in the calendar year 2027 Medicare Physician Fee Schedule that may hinder access to high-quality musculoskeletal care.
“These are large, serious, dangerous changes — the most we have seen in 30 years — and we are working with CMS to try to put things on pause, to hold onto our 2026 payment options,” Wilford K. Gibson, MD, FAAOS, president of the AAOS, told Healio. “Then, hopefully, have CMS give us some time to work with them to try to work through some of

FDA OKs Lyrfigtu for previously treated bile duct cancer

The FDA approved lirafugratinib — a kinase inhibitor — for adults with previously treated unresectable, locally advanced or metastatic cholangiocarcinoma.
The indication for lirafugratinib (Lyrfigtu, Elevar Therapeutics) applies to patients with a fibroblast growth factor receptor 2 (FGFR2) gene fusion or other rearrangement.
The FDA based its decision on results from the phase 1/2 REFOCUS trial, which enrolled 116 patients with unresectable or metastatic cholangiocarcinoma who had received prior chemotherapy or chemoimmunotherapy but had not previously received an FGFR inhibitor.
Patients

Expert urges caution despite ‘encouraging signs’ in Ebola outbreak

There has been some recent optimism that the Ebola virus outbreak in the Democratic Republic of the Congo may have slowed after spreading faster than any other outbreak on record.
“We’re now starting to see encouraging signs that we’re gaining ground,” WHO Director-General Tedros Adhanom Ghebreyesus, PhD, MSc, said in a press conference last week. “In the most affected parts of the Ituri province, transmission is going down.”
The outbreak is being caused by the relatively rare Bundibugyo species of the virus, for which there are no licensed vaccines or

Optometry Giving Sight kicks off World Sight Day Challenge

Optometry Giving Sight’s participation in the 2026 World Sight Day Challenge, a fundraising campaign mobilizing the optometric industry and communities to support access to vision care, is in full swing.
From Sept. 1 to Oct. 31, supporters worldwide can participate in fundraising challenges to expand Optometry Giving Sight (OGS)-funded programs that provide eye exams, glasses and optometry training in communities lacking vision care, according to a press release.
The challenge is highlighted by World Sight Day, observed annually on the second Thursday of October — this year, Oct. 8.
“Every

Sleep patterns may influence over 150 diseases

The durations of total, deep and rapid eye movement sleep were tied to risks for 156 diseases, according to a study published in PLoS Medicine.
Previous studies have established links between sleep and risks for mortality and morbidity, Jingsong Luo, PhD, a researcher at Peking University in China, and colleagues wrote, although “most have primarily focused on sleep duration as measured by self-reported questionnaires.”
“Moreover, there remains limited understanding of how other real-world sleep patterns, such as sleep stages and fragmentation, relate to health outcomes,” they wrote.
The

OLN324 improves anatomy, retinal fluid in wet AMD

LAS VEGAS — OLN324, a VEGF and Ang-2 inhibitor for wet age-related macular degeneration, achieved improvements in anatomy and retinal fluid that were comparable to faricimab, according to a speaker at Clinical Trials at the Summit.
“In the JADE study, we looked at two doses of OLN324 (Ollin Biosciences), 2 mg and 4 mg, and this was compared to faricimab,” Arshad Khanani, MD, MA, FASRS, of Sierra Eye Associates in Reno, Nevada, told Healio. “The JADE study included patients with neovascular AMD who were treatment-naive as well as DME.”
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According to Khanani, who focused on neovascular

CDC awards grant to discern pediatric epilepsy prevalence

The CDC has awarded a $1.6 million grant that will be used by researchers to gain a better understanding of the prevalence of pediatric epilepsy in the U.S.
Zachary Grinspan, MD, MS, director of the Pediatric Epilepsy Program at Weill Cornell University, and colleagues will use the funding to carry out the Collaboration to Estimate the Pediatric Incidence of Epilepsy, which he said will combine data from eight sources.
As of 2022, the CDC estimates that 456,000 children in the U.S. aged 17 years and younger, or roughly six in every 1,000 children, have active epilepsy.
However, those estimates

Immunotherapy increases risk for major cardiovascular events

Treatment with immune checkpoint inhibitors can significantly increase risk for major adverse cardiovascular events among patients with cancer, including heart failure, myocardial infarction and stroke.
A retrospective analysis of more than 30,000 patients showed individuals treated with immune checkpoint inhibitors had a 40% higher risk for hospitalization from these events than those who received guideline-concordant frontline chemotherapy.
“These drugs have taken cancers that used to be a death sentence and made them survivable. That is not in dispute,” Salim S. Hayek, MD, chair of internal

Joseph P. Zackular, PhD, explains C. difficile’s impact on babies

Although it does not produce symptoms typically seen in adults, emerging research suggests that Clostridioides difficile does have an impact on infants’ microbiome.
An estimated 40% to 70% of infants are colonized with C. difficile within the first 2 years of life, but they are usually asymptomatic. Researchers have been trying to understand why.
“This has been a mystery in the field for a really, really long time,” Joseph P. Zackular, PhD, codirector of the Center for Microbial Medicine at Children’s Hospital of Philadelphia, told Healio.
Zackular and colleagues at CHOP and the University of