The beta cells in our pancreas act as highly sensitive sensors that constantly measure the amount of sugar in our blood. As soon as we eat something and the sugar level rises, the beta cells produce insulin to help the body process the sugar properly. This process requires an enormous amount of energy from the cells, which they generate in their own internal power stations, the mitochondria. Research now shows that iron is the crucial fuel that enables these power plants to function during cell growth. The findings are published in the journal Nature Communications.

Isaiah Kletenik, MD, and Julian Kutsche, of the Center for Brain Circuit Therapeutics within the Mass General Brigham Neuroscience Institute, are the senior and lead authors of a paper published in Cortex, titled "Lesions Causing Aphantasia are Connected to the Fusiform Imagery Node."

Once a niche challenge for hardcore athletes, Hyrox has become one of the fastest-growing fitness trends worldwide. It blends elements of endurance running with functional strength work in a way that appeals to both strength and cardio enthusiasts.

Eight hours of sleep used to be the norm, and all-nighters with only a few hours of rest were rare among teenagers. In recent years, however, there has been an alarming decline in sleep duration. It has reached a point where insufficient sleep among teens is considered a major public health problem in the US.

Researchers at Memorial Sloan Kettering Cancer Center (MSK) have made an important discovery about how genetic mutations in breast cancer patients can interact and drive resistance to certain drugs called CDK4/6 inhibitors. This finding, published in Nature, suggests a new strategy for predicting and preventing resistance to specific therapies based on the tumor's genetic profile.

Starting elementary school is a major milestone, but it can be a difficult transition as children can experience separation anxiety or have trouble adapting to school rules and structure. However, a team led by Penn State researchers found that consistent routines in the home can reduce the likelihood that children will struggle with the school transition.

The gut bacterium Bacteroides fragilis has long presented researchers with a paradox. It has been associated with colorectal cancer, yet it also lives quite happily in most healthy people. A study by a Danish research team offers a possible clue. When they looked beyond the bacterium itself and into its genome, they found a previously unknown virus embedded within it—one that was significantly more common in cancer patients.

A large cohort study of more than 600,000 US veterans with type 2 diabetes found that initiating GLP-1 receptor agonists was associated with lower risks of developing substance use disorders compared with SGLT-2 inhibitors. Among veterans with existing substance use disorders, GLP-1 receptor agonist use was also linked to fewer overdose events, hospitalizations, and suicide-related outcomes.

A large longitudinal study of U.S. adults found that many older people improve in cognitive function or walking speed over time, challenging the idea that aging inevitably leads to decline. Positive beliefs about aging were associated with higher odds of improvement in both cognitive and physical health.

Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular resilience. The study proposes somatic genomics as a powerful strategy to uncover disease mechanisms and identify new therapeutic targets across multiple conditions.