Once-daily injectable vosoritide conferred a larger increase in annualized growth velocity compared with placebo among children with hypochondroplasia, according to data from a phase 3 trial published in NEJM Evidence.
As Healio previously reported, vosoritide (Voxzogo, BioMarin Pharmaceutical) became the first medication approved by the FDA to improve growth for children with achondroplasia with open epiphyses. However, there are currently no FDA-approved medications to treat hypochondroplasia, another skeletal condition that causes short stature in children, according to Andrew Dauber, MD,

Conclusions from electronic health record-derived studies agreed with established evidence 4 out of 5 times, despite methodological differences, a researcher reported.
The findings suggest databases can provide useful clinical signals, according to Samuel Tringali, DO, a resident physician at the University of Florida College of Medicine and investigator of the study.
“Dermatology research is increasingly using large clinical databases, so clinicians are going to encounter more studies based on real-world EHR data,” Tringali told Healio. “Until now, we had not systematically asked a very basic

Driven by declining vaccination rates, measles, which was declared eliminated in the United States in 2000, is seeing a major resurgence.
The CDC reported 2,777 confirmed cases on Aug. 20, surpassing the previous year’s total of 2,289 cases. About 94% of cases have been among unvaccinated individuals.
The Pennsylvania Department of Health reported two measles-related deaths in August and two in September, all in unvaccinated people.
Three additional deaths occurred in 2025; these three deaths were the first deaths related to measles in the U.S. since 1991.
“Compared to 10 or 20 years ago, it has

Increased consumption of saturated and animal fats can have a significant impact on survival for men with prostate cancer.
An analysis of nearly 5,000 patients showed those who consumed the most saturated fat had a 24% higher overall mortality risk and 42% greater risk for death from cardiovascular disease, and those who ate the most animal fat had a 49% higher risk for death from other malignancies.
However, replacing just 5% of calories from saturated fats with monounsaturated fats could lower mortality risk 20%.
“It’s never too late for patients to change their diet,” Lorelei A. Mucci, ScD,

The FDA has granted breakthrough therapy designation to the DT120 Orally Disintegrating Tablet after preliminary clinical evidence showed significant improvements in treating major depressive disorder.
The drug is being developed by Definium Therapeutics and previously received a breakthrough therapy designation related to generalized anxiety disorder (GAD).
Dan Karlin, MD, MA, chief medical officer with Definium, said the designations reflect the existing high unmet need for treating both GAD and MDD as well as recognition from the FDA that DT120 ODT (lysergide) could meet that need in ways

The annualized rate of moderate/severe COPD exacerbations was significantly lower among patients receiving add-on subcutaneous tozorakimab vs. placebo every 4 weeks, according to data published in The New England Journal of Medicine.
These results on the anti-IL-33 monoclonal antibody tozorakimab (AstraZeneca) were simultaneously presented at the European Respiratory Society International Congress.
“The OBERON and TITANIA trials mark the first time we have seen a biologic in COPD achieve efficacy in a broad population across blood eosinophil thresholds, including in patients with baseline

In addition to oral immunotherapy, pediatric patients with certain food allergies in Colorado and surrounding states can now receive sublingual immunotherapy to treat their allergy, according to a press release.
“We’re proud to be among the few pediatric medical centers in the surrounding region to offer sublingual immunotherapy (SLIT),” Allison Hicks, MD, director of food immunotherapies and the food challenge and research unit at Children’s Hospital Colorado (Children’s Colorado), told Healio.
The release outlined that SLIT is available for the following allergens through the new program at

Instrumented metatarsus adductus and hallux valgus correction may shorten recovery time and significantly improve radiographic measures, according to interim results presented at the American Orthopaedic Foot & Ankle Society Annual Meeting.
“This is a relatively complex midfoot reconstruction. It is not just a bunion correction,” Mark E. Easley, MD, a foot and ankle orthopedic surgeon at Duke Health in Durham, North Carolina, told Healio. “Yes, you can struggle performing the surgery freehand, but this instrumented system makes that task more predictable, more reliable and makes this

A girl with FOXP1 syndrome banged her head for years despite treatment. A Parkinson's drug given for her feet brought an unexpected change.

A 12-year-old had a week of nosebleeds and trouble swallowing after drinking stream water. Doctors found a live 8-cm leech in her throat.