Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging

People who carry the APOE2 version of the apolipoprotein E gene are more likely to live to advanced age and are partly protected against Alzheimer's disease, but scientists have struggled to explain why. A new study from the Buck Institute for Research on Aging, now published in Aging Cell, offers a mechanistic answer: APOE2 helps human neurons keep their DNA intact and resist becoming senescent, a damaged, dysfunctional state that accumulates with age and contributes to neurodegeneration.

Belonging after disaster: How ‘ibasho’ may aid mental health recovery

Natural disasters drastically affect human lives—destroying homes, separating families, leading to disruption of daily routines, which affects their stability. While emergency mental health responses are crucial in the beginning of the crisis, new correspondence discusses that psychological recovery may rely on a more meaningful approach to help restore a sense of place and belonging.

Metabolic health emerges as key to brain and memory problems in bipolar disorder

While they share similar depressive and cognitive symptoms, the biological underpinnings of bipolar disorder and major depressive disorder are distinct. A novel study appearing in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is the first to identify clinically relevant pathways linking metabolic dysfunction, brain structure, and cognition in mood disorders, with stronger and more specific effects observed in bipolar disorder. It highlights the potential of targeting metabolic pathways to improve cognitive symptoms in bipolar disorder.