Safety similar across advanced Crohn’s disease therapies

The safety profiles of several commonly used advanced therapies for Crohn’s disease appear similar, with no significant differences observed in risks for serious infections and cardiovascular adverse events, according to study results.
“While individual patient risk factors must always be considered, the overall safety profiles appeared broadly comparable in real-world practice,” Siddharth Singh, MD, professor of medicine at Mayo Clinic College of Medicine, told Healio.
“This [research] suggests that treatment decisions can be guided primarily by effectiveness, patient preferences, prior

AI scribes significantly improve output, clinician satisfaction

The only typing clinicians may need to do in the future is to enter their login information.
AI scribes have the capability to transform health care, and a randomized trial demonstrated its benefits at both the system and clinician level.
The investigation found clinicians who used an AI scribe for 8 weeks could see approximately two more patients and increase billing roughly $800 per day, significantly reduce their documentation time and improve their work-life balance.
“AI scribes work,” Nima Toussi, BSc, a fourth-year medical student at University of Saskatchewan in Canada, told

Move more to cut risk for hypertensive disorders in pregnancy

Limiting sedentary time and increasing light-intensity physical activity may reduce risk for developing a hypertensive disorder of pregnancy, according to study findings.
“Clinicians should consider counseling pregnant patients not only about exercise, but also about their everyday movement patterns. Based on our findings, limiting sedentary time to no more than 10 hours per day, and ideally closer to 8 hours, may help reduce the risk of developing a hypertensive disorder of pregnancy. Encouraging frequent light-intensity movement throughout the day appears to be an important and

Zeiss Collaborative Care connects eye doctors in real time

ORLANDO — Eye care practitioners can use Collaborative Care, a new cloud platform launched by Zeiss Medical Technology, to share data and streamline referrals.
“It’s bringing providers together, whether they’re optometrists connecting to other optometrists or optometrists connecting to MDs,” Austin Ghiossi, strategic marketing manager at Zeiss Medical Technology, told Healio at Vision Expo. “It’s really about strengthening the connectivity and the continuity of care across the entire ophthalmic workflow.”
Collaborative Care allows optometrists and

Skin barrier function in atopic dermatitis better with dupilumab

Children with moderate to severe atopic dermatitis had improved skin barrier function with 16-week dupilumab treatment in both lesional and nonlesional skin, according to data published in Annals of Allergy, Asthma & Immunology.
“Our study demonstrates that dupilumab helps normalize the skin barrier in children, including areas of skin that appear clinically unaffected,” Donald Y.M. Leung, MD, PhD, director of the food allergy and asthma program at National Jewish Health, said in a press release. “These findings suggest we may be addressing the underlying disease process, not just treating

Oral drug cuts HbA1c, improves C-peptide in type 2 diabetes

Adults with insulin-deficient type 2 diabetes had a decrease in HbA1c that was maintained for 1 year after receiving a once-daily oral therapy for 12 weeks, according to data from the COVALENT-111 trial.
Icovamenib (Biomea Fusion) is a novel small molecule menin inhibitor under investigation for the improvement of beta-cell function in adults with insulin-deficient type 2 diabetes. In findings from the COVALENT-111 phase 2 trial presented at the International Conference on Advanced Technologies & Treatments for Diabetes, icovamenib was tied to decreased HbA1c — which persisted after

VIDEO: Calabrese discusses impact of GLP-1 medications

In this Healio video exclusive, Leonard H. Calabrese, DO, chief medical editor of Healio Rheumatology, highlights the latest cover story on the expanding use of GLP-1 receptor agonists and what they represent across specialties.
“GLP-1 is kind of the story of the moment, and not only of rheumatology but the world,” he said. “We are in the middle of a very exciting time, elucidating and trying to capitalize on the immunologic effects of this family of drugs and related compounds. Stick with us and we’ll keep you posted.”
Calabrese additionally noted a feature story

It may be too soon to scrap Daylight Saving Time, suggests research

Ahead of the beginning of Daylight Saving Time (DST) on 26 March, a comprehensive international review by researchers at the University of Kent has highlighted the complex arguments for and against scrapping the twice-yearly clock change, and the need for more evidence before a decision can be made. Calls to scrap Daylight Saving Time have intensified in recent years with campaigners often emphasizing the negative consequences it has on public health and well-being in the UK. However, a review of 157 studies from 36 countries led by the Medway School of Pharmacy in partnership with researchers at the University of Cologne suggests that this simple messaging can be misleading.

As antibiotics fail, a new treatment targets the host, not the bacteria

As antibiotic resistance continues to rise worldwide, scientists are searching for new strategies to combat infections. This latest research at Trinity Translational Medicine Institute at Trinity College Dublin combats this problem by focusing on strengthening an individual's own defense systems rather than relying solely on antimicrobial drugs. This approach aims to boost immune function to help clear infections more effectively. The study is published on World TB Day in the journal JCI Insight.