Adults with ADHD and comorbid anxiety experienced improvements in both with centanafadine, according to a press release from Otsuka Pharmaceutical.
Currently under investigation, centanafadine is a norepinephrine, dopamine and serotonin reuptake inhibitor that Otuska called first-in-class.
“Despite available treatment options, many individuals continue to experience residual symptoms, side effects or functional impairments,” Thomas Thompson, MD, DFAPA, vice president of global clinical development at Otsuka Pharmaceutical, told Healio.
Thompson noted that adults with ADHD and anxiety comprise a

Chronic insomnia was associated with higher risk for developing mild cognitive impairment and dementia, and individuals with reduced sleep had a higher rate of cognitive decline and more white matter hyperintensities, according to a study.
The study showed that chronic insomnia is a potential modifiable risk factor for dementia, Diego Carvalho, MD, MS, a clinical neurophysiologist with the Mayo Clinic, told attendees at the Alzheimer’s Association International Conference 2026.
“Aging is associated with a lot of changes in our sleep that may contribute to insomnia, starting with changes in

KIAWAH ISLAND, S.C. — In this video from Kiawah Eye & Retina, C. Ellis Wisely, MD, MBA, discusses the success of topical recombinant nerve growth factor drops in the treatment of neurotrophic keratitis.
“I’m excited about other pharmacological therapies coming out on the market, such as more sustained-release similar options in gel or ointment-like forms that may require fewer drops per day and be a little bit less burden on patients in terms of six or eight drops a day. It could be fewer administrations,” Wisely, of Duke Eye Center, said.

People with alopecia areata are approximately four times more likely to have retinal abnormalities compared with those without alopecia areata, according to results from a systematic review and meta-analysis.
The total sample size included 10,832 individuals with alopecia areata (AA) and 134,783 controls across nine studies. Researchers found that one or more retinal abnormalities occurred in 2% of the AA cohort vs. 0.7% of controls, according to results published in the Journal of the American Academy of Dermatology.
“Patients with alopecia areata had significantly higher risk for retinal

CHICAGO — Among patients with type 2 diabetes who discontinued use of a GLP-1 receptor agonist, more than half reinitiated within 1 year and about two-thirds reinitiated within 2 years, researchers reported at ENDO 2026.
“The question we were asking is, of the patients who do go on GLP-1s, who have type 2 diabetes, how many of them actually stay on treatment?” Sanjeev Rampam, MD, resident physician at the University of Michigan, told Healio. “The adherence rates are fine in clinical trials, but in the real world, how often are patients discontinuing these drugs, and of those who discontinue,

Death from ischemic heart disease in the U.S. has declined significantly since 1990, but nearly all deaths were still attributable to modifiable risk factors such as BP, diet and LDL, according to a study published in JAMA Cardiology.
Exposure to certain modifiable risk factors for ischemic heart disease death such as high fasting plasma glucose and high BMI increased since 1990, but exposure to tobacco, lead and airborne fine particulate matter has decreased, researchers reported.
“In the U.S., ischemic heart disease (IHD) is the leading cause of death driven by modifiable metabolic,

Patients with moderate to severe acute respiratory distress syndrome receiving a monoclonal antibody treatment vs. placebo had similar safety profiles and more ventilator-free days, according to phase 2a trial results.
These findings on ALT-100, an extracellular nicotinamide phosphoribosyltransferase (eNAMPT)-neutralizing monoclonal antibody (mAb), were published in American Journal of Respiratory and Critical Care Medicine.
“There are no FDA-approved therapies to give these patients, and given the unacceptable mortality and pervasiveness of the disease, ARDS treatment remains one of the

A model can predict which children/adolescents who received an epinephrine dose for anaphylaxis before ED arrival are at risk for receiving it again after ED arrival using prehospital data, according to study findings.
These results were published in The Journal of Allergy and Clinical Immunology: In Practice.
“These findings will hopefully reassure clinicians of the safety of the 2023 Anaphylaxis Practice Parameter, namely that there are a subset of patients with anaphylaxis treated with epinephrine who can remain at home so long as they have a caregiver present and a back-up epinephrine

An insurance-supported integrative oncology program may serve as a model for delivery of guideline-concordant symptom management while overcoming barriers to access, according to study findings.
A hybrid clinic that combines insurance-billed services with low-cost self-pay options resulted in meaningful reductions in several cancer-related symptoms, including pain, anxiety, depression and fatigue.
A majority of patients treated during the clinic’s first 16 months of operation expressed satisfaction with the program and indicated they would be willing to refer others.
“People with cancer often

ACG has released a clinical guideline for the management of colonic diverticulitis in outpatient settings, highlighting the importance of imaging to rule out other diseases and lifestyle modifications to mitigate recurrence.
Colonic diverticulitis is relatively common and accounts for 1.7 million clinic visits, 452,000 ED visits and an estimated $5.5 billion in health care expenditures annually in the U.S.
At least 25% of individuals diagnosed with diverticulitis will experience recurrence, and that risk increases with subsequent episodes.
“Diverticulitis can be distressing, especially when it