Trends in the identification and treatment of ALS are expected to lead to a significant increase in clinic demand over the next decade, highlighting the need for greater investment, according to a study published in Neurology Genetics.
No prior study has estimated the number of gene-positive symptomatic and asymptomatic individuals or translated those estimates into projected clinic visits, according to Jennifer Morganroth, MD, MBA, an attending neurologist with the Mass General Brigham Neuroscience Institute and a member of the American Academy of Neurology, and colleagues.
“We now have a

A presbyopia-correcting laser treatment improved distance and near visual acuity, according to a study published in Journal of Refractive Surgery.
Ricko Wai Leung Wong, MD, and colleagues wrote that Presbyond laser blended vision (Carl Zeiss Meditec) has shown growing evidence of success, but data from Australia and the Asia-Pacific region have been limited.
“This retrospective study addresses that gap by evaluating visual and refractive results in a diverse cohort at a Western Australian center,” they wrote.
Researchers conducted a retrospective, noncomparative study of 76 eyes with

The American College of Cardiology and other medical societies issued an expert consensus decision pathway for optimal postpartum care aimed to reduce risk for future CVD.
The immediate postpartum period, even before hospital discharge after delivery, represents an important opportunity to optimize both short- and long-term CV health, as pregnancy represents a CV “stress test” and viewport into an individual’s future CVD risk, according to the document.
The report includes recommendations for the optimization of and structured approach to postpartum care for people with or

PHILADELPHIA — Using a GLP-1 receptor agonist in combination with an SGLT2 inhibitor may provide additive cardiovascular and renal benefits for people with type 2 diabetes, according to a speaker at the Heart in Diabetes CME Conference.
Silvio E. Inzucchi, MD, medical director at the Yale Diabetes Center and a Healio | Endocrine Today Editorial Board Member, said there will likely never be a formal trial conducted assessing CV or kidney outcomes for adults receiving a combination SGLT2 inhibitor and GLP-1. However, Inzucchi said, data from observational studies and other trials may provide

CHICAGO — Osilodrostat conferred a broad range of quality of life improvements for people with Cushing’s disease in two trials, researchers reported.
As Healio previously reported in the LINC 4 trial, osilodrostat (Isturisa, Recordati) normalized urinary free cortisol excretion for 77% of adults with Cushing’s disease receiving the medication. Additionally, in the LINC 3 extension trial, 81.1% of participants receiving osilodrostat who were responders during the 48-week core trial were deemed to be complete responders to therapy at 72 weeks.
During a presentation at ENDO 2026, Beverly M.K.

About half of adults treated with electroconvulsive therapy for depressive disorder experienced sustained response 12 months later, according to a poster presented at the American Psychiatric Association Annual Meeting in San Francisco.
Additionally, approximately half of the patients who did not have an immediate response saw improved outcomes at 12 months, according to Simon Kung, MD, associate professor of psychiatry, and Isabel Yoon, MD, MS, a third-year resident, both at Mayo Clinic.
“ECT is an accepted treatment with a high success rate for severe depression in psychiatry. However, we

When gastric residual volume was not regularly assessed in pediatric patients on ventilation undergoing enteral feeding, nutritional achievement at 72 hours improved, according to study results.
Findings, published in JAMA, also showed that no routine assessment was noninferior to the usual care relative to mortality and days spent ventilated.
Gastric residual volume (GRV) — the quantity of fluid obtained when aspirating a gastric tube — is regularly assessed in many ICUs. The practice is intended to reduce risk for ventilator-associated pneumonia, necrotizing enterocolitis in infants, vomiting

An analysis of health care workforce data projected significant shortages of rheumatologists in the United States, particularly in the South and non-metropolitan areas, by 2037, according to findings published in Arthritis Care & Research.
“We noticed long wait times and difficulty among our patients in accessing rheumatologists at our institution,” Jason Silvestre, MD, of the Medical University of South Carolina, told Healio. “Thus, we wanted to see if this was a national issue.”
To examine current and future U.S. rheumatology workforce shortages, as well as geographic disparities across