GlomCon Hawaii encouraged ‘deep dive’ into rare glomerular diseases

In this video from GlomCon Hawaii, Paul E. Hanna, MD, MSc, FASN, senior associate consultant in nephrology at Mayo Clinic, discusses his experience at the meeting.
“GlomCon Hawaii is one of my favorite conferences that I like to attend,” Hanna said.
“I truly enjoyed it this year because it’s the one meeting that is completely built around glomerulonephritis, with a dedicated focus and deep dive into each rare disease pathophysiology, pathology, treatment and management,” Hanna said.

Expert discusses ongoing IgA nephropathy research, development of future trials

In this video from GlomCon Hawaii, Paul E. Hanna, MD, MSc, FASN, discusses highlights from current phase 3 immunoglobulin A nephropathy trials and the design and implementation of future trials.
Hanna, senior associate consultant in nephrology at Mayo Clinic, described current phase 3 trials and how they are being expanded as they move to phase 4, with a focus on inhibitors related to the pathogenesis of IgA nephropathy.
The talk also covered which test results should be evaluated in future studies “to guide individualized treatment decisions and hopefully better predict long-term renal

Much preparation needed to become a speaker, key opinion leader

Click here to read the Healio Exclusive, “Experience builds confidence when it comes to speaking at meetings.”
I am often asked by residents, fellows and younger ophthalmologists to share the pathway to becoming a key opinion leader in ophthalmology and a regular invited speaker at educational meetings.
In the following paragraphs, I will share a few thoughts gained from my personal journey as a lecturer and a frequent organizer of educational programs today.
Remember, there is no elevator to success or excellence as a key opinion leader (KOL) or speaker — you must take the stairs. The first

Glucose, insulin sensitivity fluctuate during menstrual cycle

Glucose and insulin sensitivity vary during the menstrual cycle for women with type 1 diabetes, highlighting the need for automated insulin delivery systems that account for these variations, researchers reported.
“Insulin requirements, mean glucose and carbohydrate intake peak in the luteal phase, [and] time in range is lower,” Martina Rothenbühler, PhD, scientific program manager at Diabetes Center Berne in Switzerland, told Healio. “Modeled insulin sensitivity is lower in the midluteal phase vs. early follicular phase. There is substantial individual variability; changes in insulin

Patients need community-based vascular access care

Recently, a patient on dialysis came to see me who had not been able to receive treatment in 3 weeks. He had shown up to a hospital for a routine vascular access procedure, been placed on a table and then bumped for something more urgent.
Nobody called to reschedule. Nobody followed up. He simply fell through the cracks.
Until the patient found my clinic, he had gone without dialysis for 3 weeks, which could have led to his death from renal failure.
As an interventional nephrologist in Memphis, Tennessee, I treat patients with end-stage kidney disease every day. These patients are among the most

Water fluoridation continues to be safe at recommended levels

Children who had prenatal exposure to fluoride in drinking water near or above current recommended levels in the United States had lower scores in fluid reasoning, according to data published in the American Journal of Epidemiology.
With each additional 0.1 mg/L of fluoride above 0.675 mg/L, researchers wrote, scores fell by 0.67 points (95% CI, –0.92 to –0.42). Optimal concentration, according to the U.S. Public Health Service, is 0.7 mg/L.
The researchers did not note any associations between exposure to fluoride and crystal reasoning, although they suggested that revision of the EPA’s

Patients receiving omalizumab start OIT at maintenance doses

After receiving a short course of omalizumab, 97% of patients started daily oral immunotherapy maintenance dosing for at least one of their food allergens, according to data published in Annals of Allergy, Asthma & Immunology.
“For clinicians, the key takeaway is that a short course of omalizumab started at least 8 weeks before oral immunotherapy can allow patients to start directly at low maintenance doses,” Colleen M. Shannon, MD, MPH, allergy fellow at Children’s Hospital of Philadelphia, told Healio. “Although adverse events were common, they were typically mild and not

Early discharge clinic for blood cancers ‘wonderful success’

When Christina A. Mallilo, DNP, MBA, AGACNP-BC, ANP-C, and colleagues first broached the idea of an early discharge clinic for patients with hematologic malignancies at Northwell Health Cancer Institute, some clinicians were hesitant.
“Initial feedback from the team was cautious: ‘Are we considering discharging patients following induction chemotherapy while they are neutropenic? How will we manage potential complications like fevers or sepsis?’” Mallilo, manager of advanced clinical providers at R.J. Zuckerberg Cancer Center of Northwell Health Cancer Institute, told Healio.
The response

Belting a tune may be better for belching than breathing exercises

Patients with supragastric belching reported greater symptom relief and improvements in health-related quality of life with singing therapy than diaphragmatic breathing, study results showed.
Findings also suggested that singing therapy could be particularly beneficial for older patients with severe symptoms.
“Supragastric belching significantly impairs quality of life,” Haitao Shang, PhD, of the department of gastroenterology at Qingdao Hospital in China, and colleagues wrote. “Although diaphragmatic breathing is recommended as a first-line intervention in clinical guidelines, some patients

Opioid use disorder ‘relatively common’ in rheumatic disease

Although opioid use disorder is “relatively common” in rheumatology settings, fewer than 15% of patients with this disorder and rheumatic disease receive medications to treat it, according to data published in Arthritis Care & Research.
“Patients with rheumatic conditions are prescribed opioids at higher rates than the general population, but we know very little about opioid use disorder in this group,” Jacob S. Riegler, MD, MBA, MSBE, a rheumatology fellow in the section of clinical sciences and the division of rheumatology, inflammation and immunity at Brigham and