Breta Meria Conole was in a state psychiatric hospital for more than two decades. But the reason why is a family mystery.

Humans continuously adapt their actions and behaviors in response to changes in their surrounding environment. Past neuroscience studies suggest that this adaptation process relies on the brain's ability to translate abstract goals or rules into specific physical actions or behaviors, yet its neural underpinnings have not yet been clearly elucidated.

This in vitro study found that negatively charged SiO2 nanoparticles suppressed antigen-induced degranulation and activation-marker changes in IgE-sensitized mouse bone marrow-derived mast cells. By contrast, mTiO2 nanoparticles showed cytotoxic and pro-inflammatory effects, including enhanced DNP-induced IL-6 release, suggesting nanoparticle composition can shape early allergic immune responses.

Spatial and single-cell analyses of human donor pancreata showed that PanIN epithelial cells gradually acquire cancer-like molecular features, while their surrounding stromal and immune environment remains closer to normal pancreatic tissue. The findings suggest that delayed or incomplete microenvironmental reprogramming may help explain why most PanIN lesions remain indolent rather than progressing to pancreatic cancer.

The 2026 CDC Nutrition Report will make nearly 24 years of NHANES biomarker data easier to use, covering up to 131 nutritional biomarkers in the US population aged 1 year and older. By standardizing blood and urine biomarker trends, demographic patterns, and comparisons of supplement use, the report aims to support nutrition policy, clinical reference intervals, and public health monitoring.

The review finds that several candidate biomarkers may help estimate fruit and vegetable intake more objectively than self-reported dietary tools, but most remain limited by specificity, sampling burden, supplement use, or incomplete validation. Blood and skin carotenoids appear strongest for habitual intake, while vitamin C, folate, urinary flavonoids, hippuric acid, and potassium may be more useful for short-term intake or intervention adherence.

A new review article is drawing attention to the growing global impact of human papillomavirus (HPV) and the rapid progress in vaccines and therapeutic strategies aimed at reducing the burden of cervical and non-cervical cancers.

A newly published review article brings attention to the expanding role of RBM15, a critical regulator of RNA m6A methylation, in the development and progression of a wide range of diseases, including cancer, metabolic disorders, and cardiovascular conditions.

A new review shines a spotlight on efferocytosis, a critical biological process responsible for the removal of dead cells, as a central force in promoting efficient wound repair and maintaining tissue balance.

A new review article brings attention to the critical role of DNA methylation heterogeneity in shaping the tumor microenvironment, highlighting its growing importance in understanding cancer progression and advancing more precise treatment strategies.