CHICAGO — Most adults receiving a once-weekly hypoparathyroidism therapy were able to maintain normal calcium levels at 12 weeks without active vitamin D and oral calcium supplementation, according to data from a phase 2 trial.
Mishaela R. Rubin, MD, assistant professor of clinical medicine at Columbia University Irving Medical Center in New York, said conventional management of hypoparathyroidism with vitamin D and calcium supplementation does not address all complications of the disease. As Healio previously reported, the FDA approved palopegteriparatide (Yorvipath, Ascendis Pharma) for the

The FDA has granted accelerated approval for teplizumab-mzwv as the first disease-modifying therapy for children and adolescents with stage 3 type 1 diabetes, according to an industry press release.
As Healio previously reported, teplizumab-mzwv (Tzield, Sanofi) was originally approved by the FDA in November 2022 to delay stage 3 type 1 diabetes among children and adults with stage 2 disease. In April, the FDA expanded the approval of teplizumab-mzwv to delay stage 3 type 1 diabetes to include children aged 1 to 7 years. The new approval for teplizumab-mzwv will allow the therapy to be used to

Academic cardiology is being threatened by funding cuts, program consolidations, reduced salaries and burnout, making private practice appealing to many emerging trainees, researchers reported.
The Association of Professors of Cardiology (APC) convened a group of emerging leaders in the cardiology community to construct a new “Roadmap to Revitalizing Academic Cardiovascular Medicine,” which thoroughly details the major issues facing academia today, but also provides solutions to these hurdles.
Sanjay Rajagopalan, MD, MBA, FACC, FAHA, chief of cardiovascular medicine and chief academic and

CHICAGO — In this video, Sherry Shen, MD, discusses her educational session on lifestyle and survivorship for patients with breast cancer, with a specific focus on GLP-1 use, presented at ASCO Annual Meeting.
According to Shen, up to 50% of women with breast cancer experience weight gain after their diagnosis. Although lifestyle modifications can aid in weight management for this patient population, results are “relatively modest.”
A review of retrospective data showed women with breast cancer who use GLP-1s typically lost less weight than other users. However, early signals

Black children are less likely to see a pediatric dermatologist compared with white children despite having a higher frequency of common dermatologic conditions — part of a broader pattern of barriers to care among underrepresented groups.
Despite having higher incidence rates for atopic dermatitis, acne and hidradenitis suppurativa, Black children across eight U.S. children’s hospitals saw dermatologists less often than white children, according to an analysis of electronic health records published in JAMA Dermatology.
“Access to specialty care plays a major role in health outcomes,” Lucinda

CHICAGO — In this video, Mitchell Singstock, MD, discusses results of a retrospective study that evaluated genomic testing rates for prostate cancer and whether an AI model could improve risk stratification and testing eligibility.
Findings, which were presented at ASCO Annual Meeting, showed the model demonstrated 100% accuracy in 2025 in recommending National Comprehensive Cancer Network-indicated germline and somatic testing for this malignancy.
“Our next steps are to plan to integrate this with an electronic health record system so that we can automatically identify men who should get

ORLANDO — A model based on proteins vs. a questionnaire had higher discrimination in predicting lung cancer risk in individuals with a smoking history, according to data presented at the American Thoracic Society International Conference.
This study was simultaneously published in JAMA.
“The protein-based INTEGRAL-Risk model improved short-term prediction of lung cancer among people with smoking history, which could improve selection of high-risk individuals for screening,” Hilary A. Robbins, PhD, scientist at the International Agency for Research on Cancer, said during her presentation.
Using

Among pediatric patients, the risks for methicillin-resistant Staphylococcus aureus colonization, surgical site infections and all-cause mortality were each heightened if they had penicillin allergy labels, according to study results.
These data were published in Pediatric Allergy and Immunology.
“Although most children labeled as penicillin-allergic are not truly allergic, [penicillin allergy labels] often lead to avoidance of first-line beta-lactams,” Heejo Keum, MD, internal medicine resident at the University of Texas Southwestern Medical Center, and colleagues wrote. “In adults, such

In adults with prior preventive migraine treatment failures, an investigational monoclonal antibody led to larger decreases in monthly migraine days vs. placebo, according to a poster presented at a recent conference.
Bocunebart (Lu AG09222, Lundbeck) is a monoclonal antibody that targets the pituitary adenylate cyclase-activating polypeptide (PACAP) ligand, according to the presentation at the American Headache Society 68th Annual Scientific Meeting.
“For clinicians, these data suggest bocunebart could become a differentiated preventive option for highly impacted migraine patients, especially

Healio’s ninth annual Disruptive Innovators Awards for gastroenterology and hepatology will be presented this fall, honoring the pioneers whose groundbreaking work and bold ideas have redefined the field.
Awardees will be recognized during a prestigious awards ceremony at the ACG Annual Meeting, scheduled for October 9-14 in Nashville.
The event will be hosted by Healio Chief Medical Editor Edward V. Loftus Jr., MD, and Ugo Iroku, MD, MHS, a co-founder of the Association for Black Gastroenterologists and Hepatologists.
Healio is now accepting nominations in nine categories:
Lifetime Disruptor,