The 2024-2025 COVID-19 vaccine was associated with reduced risk for COVID-19-related major adverse cardiovascular events among older adults, especially those with comorbidities, researchers reported.
Coadministration of the COVID-19 vaccine alongside the annual influenza vaccine may reduce COVID-19-related and all-cause mortality among older, higher-risk individuals, according to a study published in JAMA Internal Medicine.
“The 2024-2025 COVID-19 vaccine was associated with a lower risk of COVID-19-associated MACE; absolute risk reductions were generally modest, but more pronounced in older

The eagerly awaited full dataset from the most pivotal pancreatic cancer study in decades didn’t just live up to expectations.
It far exceeded them.
ASCO Annual Meeting attendees used words like “transformational,” “unprecedented” and “paradigm shift” to describe detailed findings from the randomized phase 3 RASolute 302 trial, which establish daraxonrasib (RMC-6236, Revolution Medicines) as the new standard of care for previously treated metastatic pancreatic ductal adenocarcinoma (PDAC).
Daraxonrasib doubled OS and PFS, tripled the rate of objective response, and doubled time to deterioration

Editor’s Note: After the June issue of Healio | Endocrine Today went to press, a U.S. district judge voided the H-1B visa fee discussed in this article. The Trump administration says it will appeal.
In September, the federal government raised the application fee for new H-1B visas to $100,000.
If allowed to persist, the fee could have lasting negative effects on the U.S. physician workforce, according to the AMA and medical specialty groups. A federal judge on June 8 voided the policy instituted by presidential proclamation. The Trump administration says it will appeal.
The H-1B visa program

NASHVILLE — Bassel Molaeb, MPH, CIC, FAPIC, AL-CIP, wanted to be clear: AI will augment, not replace, human expertise in the fight against health care-associated infections.
“AI will become your colleague,” Molaeb, health care advisor, trainer and infection prevention and control consultant with The Compass Health Consultancy in Dubai, United Arab Emirates, told a packed room of infection preventionists (IPs) at the Association for Professionals in Infection Control and Epidemiology annual meeting.
Molaeb noted a recent survey coordinated by WHO in which 74.4% of respondents

PHOENIX — Mirvetuximab, an antibody drug conjugate for the treatment of certain types of cancer, can lead to adverse ocular events in the early weeks of treatment, according to a poster here.
Across four cases of folate receptor-alpha positive, platinum-resistant epithelial ovarian and fallopian tube cancer, three patients developed corneal subepithelial microcysts in the early weeks of treatment with Elahere (mirvetuximab, AbbVie).
Other findings included superficial punctate keratitis, epithelial ridge, stromal haze and posterior subcapsular cataract.
“For most, the initial presentation was in

HHS is requesting changes to prescribing information for testosterone therapy products following a review of new clinical data and scientific evidence, according to a press release from the agency.
As Healio previously reported, the FDA convened a panel in December that discussed removing some contraindications for testosterone therapy as well as taking testosterone therapy off the list of controlled substances. In an announcement on June 18, HHS proposed three changes to testosterone therapy labeling.
The first of the three changes would remove the limitation of use stating that safety and

As a result of a new partnership with Professional Communications Inc., The Vaccine Handbook joins the list of reputable references powering Healio AI to provide comprehensive, relevant and timely information to health care professionals.
Written by Gary S. Marshall, MD, and published by Professional Communications Inc., The Vaccine Handbook: A Practical Guide for Clinicians is an instrument that fuses information on licensed vaccines in the United States with general and administrative advice for health care professionals.
The resource — also referred to as “The Purple Book” — will now add an

Patients with migraine who began using GLP-1 receptor agonists for obesity did not experience any significant changes in headache outcomes, according to data presented at the American Headache Society 68th Annual Scientific Meeting.
However, initiation of these drugs was associated with less health care utilization and treatment escalation compared with topiramate, Scott Yuan, MD, PhD, director, Jefferson Headache Center, Thomas Jefferson University, and colleagues wrote.
“GLP-1 receptor agonists have growing biologic plausibility in migraine, but clinical evidence remains limited,

NEW ORLEANS — Once-daily orforglipron induced greater reductions in HbA1c than dapagliflozin and oral semaglutide for adults with type 2 diabetes, according to findings from the ACHIEVE-2 and ACHIEVE-3 trials.
As Healio previously reported from the ACHIEVE-1 trial, orforglipron (Foundayo, Eli Lilly), a small molecule oral GLP-1, conferred greater decreases in HbA1c and body weight at 40 weeks than placebo for adults with type 2 diabetes. In new data from ACHIEVE-2 and ACHIEVE-3, researchers compared efficacy of orforglipron in the type 2 diabetes populations with the SGLT2 inhibitor

Recent data suggest that 85% of dry eye disease in the U.S. is partially or completely evaporative dry eye.
This means that 85% of dry eye disease (DED) likely originates in the meibomian glands of affected patients. Now is as good a time as any to review best practices for evaluating and treating meibomian gland dysfunction (MGD).
But first we should look at the proper way to arrive at whatever we might call “best practices.”
In a recent post on my “new look” Healio blog, I offered some thoughts on what “real” science might be. We live in an era in which there is a seemingly overwhelming urge