Yo-yo dieting may pose different risks depending on starting weight

Is it harmful to your health to lose weight repeatedly and then gain it back again? In a recent article in Nature Reviews Endocrinology, DZD researchers Norbert Stefan and Faidon Magkos of the University of Copenhagen offer an assessment: The deciding factor could be the starting weight. While weight fluctuations appear to be less problematic in people with obesity than is often assumed, they could increase the risk of developing obesity in the long term among people of normal weight.

Human stem-cell model reveals a shared origin for tissue-resident macrophages

VIB researchers have developed a new human stem-cell-based model that recreates an early stage of immune-cell development and shows how a single progenitor population can give rise to specialized macrophages across different organs. The model provides a platform to study how these processes change in disease, and how they might eventually be harnessed therapeutically.