DALLAS — Sleep and satisfaction with social support mediated the relationship between adverse childhood experiences and depressive symptoms, according to data presented at the American College of Lifestyle Medicine’s annual meeting.
But stress, substance use, diet, quantity of social support and physical activity did not significantly impact this relationship, Liana Abascal, PhD, MPH, DipACLM, associate professor, California School of Professional Psychology at Alliant International University, said during her presentation.
“It’s a real simple measure,” Abascal said. “Did any of these 10 things

Up to 5% of Americans may carry genetic variants associated with cancer risk, according to a cross-sectional analysis.
The higher-than-expected prevalence of pathogenic variants in cancer-susceptibility genes — observed independent of family or personal cancer history — underscores how broader genetic testing could identify more people at risk for cancer and lead to earlier detection, researchers concluded.
“Ideally, we want to better understand who truly is at risk for cancer from a genetic perspective and who is not, as that can inform decisions about more aggressive screening or strategies

Nearly half of all patients with hemorrhagic stroke also experience headache across its acute and chronic phases that could contribute to long-term morbidity, according to a review published in Headache.
Yet the prevalence of headache varied substantially across populations and clinical settings, Bradley Ong, MD, adult neurology resident at Neurological Institute, Cleveland Clinic, and colleagues wrote.
“In clinical practice, headaches after hemorrhagic stroke came up quite often in our clinical practice, but they were rarely addressed,” Ong told Healio.
Most treatment after stroke focuses on

Employment rates for patients with end-stage kidney disease were higher for those with access to home hemodialysis or evening in-center dialysis, according to findings published in Clinical Journal of the American Society of Nephrology.
Although maintaining employment is necessary for many patients with kidney disease, only 30% to 35% of patients with advanced chronic kidney disease report being employed before beginning dialysis, according to Kevin F. Erickson, MD, MS, associate professor in nephrology at Baylor College of Medicine, and colleagues. With limited guidance and discussions

Being at high risk for obstructive sleep apnea as a middle-aged and older adult was linked to a greater likelihood for poor mental health outcomes, according to findings published in JAMA Network Open.
“For the practicing clinician, these findings support viewing obstructive sleep apnea risk as a meaningful mental health-relevant condition in older adults, not solely a sleep or cardiometabolic issue,” Tetyana Kendzerska, MD, PhD, associate scientist of inflammation and chronic disease at Ottawa Hospital Research Institute, associate professor of medicine at the University of Ottawa and sleep

Among adolescents with asthma and overweight or obesity, the relative risk for acute asthma exacerbations was significantly reduced with GLP-1 receptor agonist use vs. nonpharmacological weight management, according to study results.
These data were published in JAMA Network Open.
“For everyday clinicians, the findings highlight a potential consideration for a subset of adolescents with obesity whose asthma is particularly difficult to control and for whom weight reduction remains challenging,” Lin-Shien Fu, MD, chief of pediatric nephrology and immunology at Taichung Veterans General Hospital,

The American Association for the Study of Liver Diseases and Infectious Diseases Society of America have updated guidance on treatment of chronic hepatitis B virus, which the authors hope will give clinicians and patients more flexibility.
“This is a guideline that expands treatment, is more permissive and encourages shared clinical decision-making,” Norah A. Terrault, MD, MPH, professor of medicine, chief of gastroenterology and liver diseases, and Neil Kaplowitz Endowed Chair in Liver Diseases Research at Keck School of Medicine of USC, told Healio.
“We picked six areas that reflect, to some

Telitacicept, a dual inhibitor of the cytokines B-lymphocyte stimulator and a proliferation-inducing ligand, showed efficacy in systemic lupus erythematosus vs. placebo, according to data published in the New England Journal of Medicine.
“Despite several advances in recent years, patients with SLE continue to experience persistent disease activity, frequent flares and the side effects of conventional medications,” Ronald F. van Vollenhoven, MD, PhD, chief of the department of rheumatology and clinical immunology at the University of Amsterdam, told Healio. “In China, where this study was done,