Diclofenac gel and the topical flavonoid silymarin, or milk thistle, may be effective in preventing chemotherapy-induced hand-foot syndrome, according to a study published in JAMA Dermatology.
Hand-foot syndrome is a cutaneous adverse event of chemotherapy, characterized by tingling, numbness, desquamation, blistering and/or ulceration of the palms and soles. A dose-dependent toxic effect, hand-foot syndrome is associated with several chemotherapy drugs including 5-fluorouracil, capecitabine, liposomal doxorubicin, cytarabine and docetaxel, according to the researchers.
Capecitabine (Xeloda,

COVID-19 infection, compared with influenza, was associated with significantly greater risks for developing AKI, chronic kidney disease and end-stage kidney disease, according to study data published in Communications Medicine.
Previous studies have observed associations between COVID-19 infection and kidney disease risks, including higher risks for mortality, CVD, mental health disorders and neurologic diseases, according to Yue Zhang, PhD, MPH, postdoctoral scholar at Johns Hopkins Bloomberg School of Public Health, Nasrollah Ghahramani, MD, MS, J. Lloyd Huck Chair in Medicine and professor

Tirzepatide is linked to lower cardiovascular risk than dulaglutide for adults with type 2 diabetes and atherosclerotic cardiovascular disease, researchers reported in a study published in Diabetes Care.
In two target trial emulations conducted using information from the Optum deidentified Clinformatics Data Mart Database, researchers compared incidence of major CV events for adults with type 2 diabetes and CVD using tirzepatide (Mounjaro, Eli Lilly) vs. dulaglutide (Trulicity, Eli Lilly) and semaglutide (Ozempic, Novo Nordisk). Adults receiving tirzepatide had a lower rate of CV events than

Fewer adults with lung cancer who underwent photon-counting vs. conventional CT had an adverse reaction, according to data published in Radiology. Plus, malignant feature detection and diagnostic confidence was better with this type of CT.
“Compared with conventional CT, low-dose, ultra-high-resolution photon-counting CT improves the detection of enhancement-related malignant features across varying BMI and tumor sizes,” Songwei Yue, MMed, chief physician, professor and deputy director of radiology at The First Affiliated Hospital of Zhengzhou University in China, said in a press release.
“It

PHILADELPHIA — Adults with chronic spontaneous urticaria symptoms despite antihistamine use had reductions in disease activity with LP-003, a novel anti-IgE antibody, vs. placebo and omalizumab, according to phase 2 trial topline data.
These results on three different doses of LP-003 (LongBio) were presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting.
“The phase 2 study results show clinicians that this molecule may have efficacy [in chronic spontaneous urticaria] with favorable safety and possibly extend the dose interval to every 8 weeks at a lower dosage than

The likelihood for subjective cognitive decline was significantly elevated in perimenopausal women who reported loneliness, social isolation or both, according to results published in Menopause.
“These findings highlight the importance of psychosocial factors in cognitive health during the menopause transition, providing evidence for the early identification of high-risk individuals and offering guidance for the development of multidimensional, comprehensive psychosocial interventions, with important implications for promoting healthy aging in women,” Xiaohe Lin, MM, of the school of nursing

Physicians who treat sickle cell disease report burnout more often than those who do not, according to results of a cross-sectional national survey.
The study — the first to examine these variables specifically among physicians focused on sickle cell disease — highlights the need for multilevel interventions to support clinicians who care for a socially and medically complex patient population, researchers concluded.
“Burnout is an important topic in the medical field but we don’t discuss it enough,” senior author Layla Van Doren, MD, MBA, assistant professor of medicine at Yale School of

WAIKOLOA, Hawaii — In this expert perspective from Hawaiian Eye 2026, Richard S. Davidson, MD, of University of Colorado Anschutz, said it is important to create awareness about neurotrophic keratitis.
If a patient is suspected to have neurotrophic keratitis, the physician needs to establish that the patient has decreased corneal sensitivity.
“I would encourage all of you to pay attention to these patients,” Davidson told Healio. “If a patient has significant corneal findings, don’t just assume it’s dry eye. Check the corneal sensation and treat for