No difference in trigeminal nerve stimulation vs. sham for ADHD in young people

While proven a safe method, external trigeminal nerve stimulation was nonsuperior to sham treatment as early as 4 weeks and as long as 6 months in children and adolescents with ADHD, according to data published in Nature Medicine.
“ADHD diagnoses are rising rapidly and there is a need for effective, preferred non-drug treatments,” Katya Rubia, PhD, senior study author and professor of cognitive neuroscience at the Institute of Psychiatry, Psychology and Neuroscience, King’s College London, told Healio.
ADHD is a common neurodevelopmental condition that affects approximately 5% of all

Tuna recalled over botulism risk shipped to nine states by mistake

Canned tuna that was recalled in February 2025 due to a botulism risk was “inadvertently” shipped to stores in nine states on Monday, prompting a new warning to consumers from the FDA.
Tri-Union Seafoods ordered the initial recall due to a manufacturing defect that could compromise the product’s seal, potentially leading to contamination with Clostridium botulinum, a toxin that causes botulism and attacks the body’s nerves.
No illnesses have been reported. Nevertheless, any botulism warning must be heeded, according to epidemiologist Kirk Smith, DVM, PhD, MS, of the Minnesota Department of

Exposure, reaming and screw placement key to acetabular revision

WAIKOLOA, Hawaii — At Orthopedics Today Hawaii, Don Garbuz, MD, FRCSC, MHSc, spoke about several keys for successful acetabular revision surgery.
“Over 95% of [acetabular revisions] can done be with a hemispherical shell [and a] multi-holed, highly porous shell,” Garbuz, professor and head, division of lower limb reconstruction, department of orthopaedics at the University of British Columbia, told Healio.
“The key to doing the revision is getting an adequate acetabular exposure. You want to see 360° around the cup,” he said. “You want to ream, and that is

Tips to treat chronic hand eczema in winter from Bruce Brod, MD

Editor’s Note: This is part one of a three-part Healio Dermatology winter skin series, where experts discuss common seasonal skin conditions, treatments and trends.
The cold, dry air of winter brings challenges for those with chronic hand eczema.
Chronic hand eczema (CHE), defined as hand eczema lasting 3 months or longer or relapsing twice or more within a year, is a common condition in the United States, Healio previously reported. Of the nearly 10% of Americans who have CHE, many face particularly worsened flares in the winter months, making treatment and management strategies crucial during

Increased BMI, blood pressure raise odds for dementia

Adults with higher BMI or increased blood pressure may be more likely to develop vascular-related dementia, researchers reported in The Journal of Clinical Endocrinology & Metabolism.
“Our findings show that overweight and high blood pressure are direct causes of increased dementia risk — that makes them highly actionable targets for dementia prevention at the population level,” Ruth Frikke-Schmidt, MD, PhD, DMSci, chief physician at Copenhagen University Hospital – Rigshospitalet and clinical professor at University of Copenhagen, Denmark, told Healio. “These data can, however, not be

GLP-1 strategy for CKD requires patient engagement

Diabetes care is undergoing a major transformation driven by GLP-1 receptor agonists, which have expanded beyond glycemic control to include weight management, cardiovascular risk reduction and kidney protection.
Since 2024, FDA approvals for GLP-1 medications for obesity, CV risk and chronic kidney disease — and even GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists for sleep apnea — have accelerated clinical adoption.
Clinical benefits are clear in reducing CV events and slowing CKD progression, but the financial return on investment (ROI) remains in flux. Current

ACE inhibitor use before IPF diagnosis lowers mortality risk

Among patients with idiopathic pulmonary fibrosis, the risk for all-cause mortality was significantly lower with vs. without angiotensin-converting enzyme inhibitor use started within 5 years before IPF diagnosis, according to study data.
“These findings highlight the value of investigating well-established medications for new therapeutic roles in progressive diseases such as IPF, in which current treatment options are limited,” Burcu Ozaltin, PhD, honorary research fellow at University College London, and colleagues wrote in CHEST.
In a retrospective analysis, Ozaltin and colleagues evaluated

Study offers new insights into time toxicity of cancer treatment

Older adults with advanced cancer are spending more time than ever interacting with the health care system, according to results of a cohort study.
An analysis of Medicare beneficiaries with common metastatic cancers showed their average number of health care contact days in the year after diagnosis increased considerably between 2008 and 2019.
Ambulatory days — defined as days with clinic-based care, including clinician visits, procedures, tests, treatments or imaging — accounted for much of the increase.
“We have more treatment options now compared with a decade ago, which is broadly great,

FDA grants breakthrough designation to ianalumab for Sjögren’s

The FDA has granted breakthrough therapy designation to Novartis’ ianalumab for Sjögren’s disease, according to a press release from the manufacturer.
In its statement, Novartis said it plans to submit ianalumab — a fully human monoclonal antibody that features a novel dual mechanism of action, which depletes B cells and inhibits their activation and survival via BAFF-R blockade — for approval globally starting “early 2026.” If approved, the drug would be the first ever targeted treatment for Sjögren’s disease.
“There is a huge unmet need in

Progression-free survival prolonged with sacituzumab govitecan plus pembrolizumab in triple-negative breast cancer

For patients with previously untreated, programmed death ligand 1 (PD-L1)-positive, locally advanced unresectable or metastatic triple-negative breast cancer (TNBC), sacituzumab govitecan plus pembrolizumab yields significantly longer progression-free survival than chemotherapy plus pembrolizumab, according to a study published in the Jan. 22 issue of the New England Journal of Medicine.