Hypercortisolism common in patients with resistant hypertension

NEW ORLEANS — More than one-quarter of patients with resistant hypertension had hypercortisolism, suggesting opportunities for screening, researchers reported at the American College of Cardiology Scientific Session.
Healio | Cardiology Today Editorial Board Member Deepak L. Bhatt, MD, MPH, MBA, director of the Mount Sinai Fuster Heart Hospital and the Dr. Valentin Fuster Professor of Cardiovascular Medicine at Icahn School of Medicine at Mount Sinai, and colleagues conducted the MOMENTUM study to determine the prevalence of hypercortisolism in patients with resistant hypertension.
“The purpose

Key takeaways from AACE’s 2026 type 2 diabetes algorithm

A new algorithm designed to consider all forms of diabetes when diagnosing patients is among the additions in the American Association of Clinical Endocrinology’s updated consensus statement for managing adults with type 2 diabetes.
In March, AACE published the 2026 update to its type 2 diabetes algorithm in Endocrine Practice. It is the first update of the algorithm since 2023 and was conducted in part due to the rapid evolution of medications for cardiometabolic disorders, according to Priyathama Vellanki, MD, section chief and medical director at the Grady Endocrinology Clinic at Emory

‘Over and above’ responses seen with envudeucitinib for plaque psoriasis

DENVER — Envudeucitinib, a tyrosine kinase 2 (TYK2) inhibitor, demonstrated rapid improvement and progressively deepening skin clearance for patients with moderate to severe plaque psoriasis, according to the new data.
“In the ONWARD1 and ONWARD2 phase 3 studies, envudeucitinib [Alumis Inc.], an oral next-generation TYK2 inhibitor, demonstrated biologic-like efficacy with no worrisome side effects over the course of 24 weeks in patients with moderate-to-severe plaque psoriasis,” Andrew Blauvelt, MD, MBA, owner of Blauvelt Consulting, LLC, told Healio. “These results position envudeucitinib as

Complex cataracts: Choosing the right fixation technique

Complex cataract surgery presents unique challenges when capsular support is absent or compromised by trauma, pseudoexfoliation or prior intraocular surgery.
Over the past decade, refinements in IOL fixation techniques, including scleral-sutured, Yamane-type intrascleral, iris-claw (enclavated) and piggyback IOL implantation, have expanded management options for aphakia and IOL dislocation (Beutner et al.). These approaches aim to balance long-term stability, refractive accuracy and ocular safety while minimizing postoperative complications such as tilt, decentration, cystoid macular edema and

Weight loss confers ‘meaningful’ reduction in cancer risk

Modest real-world weight loss may significantly reduce a person’s risk for cancer, according to results of a retrospective observational study.
The risk reduction conferred by nonsurgical weight loss appeared consistent over multiple time intervals.
The benefits became apparent quickly, with each 1% reduction in BMI equating to an approximately 1% reduction in cancer risk after as little as 3 years of follow-up.
“I definitely was surprised by the results, especially that we saw them as early as we did,” Daniel M. Rotroff, PhD, chairman of the department of quantitative health sciences and Eddie

EBV-positive infectious mononucleosis increases MS risk

Individuals with vs. without Epstein-Barr virus-positive infectious mononucleosis were three times as likely to develop MS, according to findings published in Neurology Open Access.
“Infection with the Epstein-Barr Virus (EBV) has been thought to increase the risk of developing MS for many years. However, it’s been difficult to prove the connection between EBV infection and MS because most people get infected with EBV when they are children or teenagers, but MS usually does not develop until people are 20 to 40 years old,” Jennifer L. St. Sauver, PhD, consultant in epidemiology and professor

Traumatic e-bike injuries are on the rise among US youth

NEW ORLEANS — A study of pediatric trauma activations showed electric bike injuries are on the rise among U.S. youth, with rates among bicycle-related injuries increasing from 1.75% in 2017 to 39% in 2023.
With greater speeds and the potential for higher-energy trauma, e-bike injuries may also account for a higher proportion of extremity injuries and fractures compared with pedal bike injuries.
“It’s reminiscent of when trampolines became wildly popular in the late 1990s,” Rachel Mednick Thompson, MD, a pediatric orthopedic surgeon at Rady Children’s Hospital, told

Study raises questions on link between inflammation, depression

Some inflammatory markers were associated with depression symptoms in women with diabetes, although the scale used to measure depression appeared to impact those associations, according to findings published in Frontiers in Psychiatry.
“There is a growing body of science that suggests inflammation plays an underlying role in depression, but findings have been largely inconsistent,” Nicole Beaulieu Perez, PhD, RN, PMHNP-BC, an assistant professor of nursing at NYU Rory Meyers College of Nursing, told Healio. “Possible explanations for these discrepancies include the

Unilateral out-of-sequence kidney transplants rose 17-fold

Out-of-sequence kidney transplants, including unilateral allocations, increased substantially between 2020 and 2024, according to study data published in JAMA Network Open.
Out-of-sequence kidney transplant allocations are used by organ procurement organizations to transplant a kidney outside of the standardized wait-list sequence, according to Miko E. Yu, MA, of the Columbia University Renal Epidemiology Group, and colleagues. By examining unilateral allocations, in which one kidney is donated in sequence and the other donated out of sequence from the same donor, the researchers could assess

1-year Arikayce improves respiratory symptoms in MAC lung disease

Amikacin liposome inhalation suspension Arikayce plus multidrug therapy for 12 months improved respiratory symptoms in patients with a new occurrence of Mycobacterium avium complex lung infection, according to topline results.
“These ENCORE results demonstrate that Arikayce as part of a multidrug regimen can deliver real clinical benefit and make a substantial difference in outcomes for patients living with Mycobacterium avium complex (MAC) lung disease,” Martina Flammer, MD, MBA, chief medical officer of Insmed, told Healio.
In the global, multisite, randomized, double-blind,