Shifts in cancer mortality: Place of living increasingly determines where historic drop in cancer mortality reaches

In 1991, the U.S. experienced a significant shift in cancer death rates, as, for the first time, deaths began a steady decline that continues to the present day. Researchers at Mississippi State's Social Science Research Center, in partnership with scientists at Oak Ridge National Laboratory, examined this decline to identify where and who benefited the most from this dramatic improvement.

Experimental drug cuts Parkinson’s-linked protein up to 60% in early trial

An experimental drug designed to silence a gene strongly linked to Parkinson's disease has shown encouraging effects in a first-in-human clinical trial, according to a study published in Nature Medicine. The drug, known as BIIB094, targets LRRK2, the most common genetic contributor to Parkinson's disease; variants in LRRK2 are known to increase the risk of developing the neurodegenerative disorder, which affects nearly 10 million people worldwide.

Antidepressant unable to prevent chemotherapy-associated nerve damage

A randomized trial conducted by the Alliance for Clinical Trials in Oncology has found that duloxetine, a medication commonly used to treat chronic pain and psychiatric conditions, does not prevent nerve damage caused by chemotherapy in patients with colorectal cancer. The primary analysis of Alliance A221805 was published in JCO Oncology Advances

Coffee’s sweet spot may help mental health in the long run

Your morning cup of coffee may be more than just a pick-me-up. It may also be a simple boost for your mental well-being. In a recent study, researchers from Fudan University, China, wanted to find out whether the amount of coffee a person drinks each day and the type they choose have any bearing on their risk of developing stress and mood disorders over time.

Molecular maps reveal how allergic reactions work and a new way to block them

Allergy affects more than one billion people worldwide—and the number is rising. For many, it means mild symptoms such as itching and a runny nose. For others, it can develop into life-threatening reactions. Now, two new studies bring researchers an important step closer to both understanding and potentially controlling the mechanisms that drive allergic disease. An international research team has mapped how the body's central allergy antibody, IgE, functions at the molecular level—and at the same time demonstrated a new way to block allergic reactions.