Two months after the FDA permitted bemotrizinol as a sunscreen ingredient, the order took effect on Aug. 9, allowing manufacturers to begin using it in U.S. sunscreen formulations, according to a press release.
The ultraviolet filter, marketed as PARSOL Shield (dsm-firmenich), was added to the FDA’s over-the-counter sunscreen monograph in June, making it the first new active sunscreen ingredient introduced to the U.S. since 1999, as Healio previously reported.
Bemotrizinol has generated interest among consumers eager to understand how the ingredient differs from existing sunscreen filters, what

Atrophy in specific areas of the brain may be able to predict the timing of dementia progression in patients with mild cognitive impairment related to early-onset Alzheimer’s disease, according to research published in Neurology.
The research examined specific areas of the brain that have been clinically validated to show greater atrophy in early-onset Alzheimer’s disease (EOAD) populations than in controls, said Alexandra Touroutoglou, PhD, MSc, associate professor of neurology at Harvard Medical School.
Touroutoglou and colleagues refer to the area, which primarily covers the

Women who had a BMI trajectory for overweight or obesity during childhood are less likely to give birth beginning at age 25 years than women who had an average BMI trajectory, researchers reported in JAMA Network Open.
In analysis of data from Denmark, researchers found women with an overweight or obesity trajectory from age 6 to 15 years had decreased odds for giving birth to a child, and the likelihood for having a child declined further with older age. However, BMI trajectories were not associated with risk for any infertility.
“Our findings suggest that the consequences of overweight and

Risks for all-cause mortality were lower for patients using hemodiafiltration vs. those using high-flux hemodialysis, according to study data published in the Journal of the American Society of Nephrology.
Evidence comparing survival rates for patients using high-volume post-dilution hemodiafiltration (HDF) vs. high-flux hemodialysis (HD) has been underpowered and may have limited feasibility in clinical practice, according to Giovanni F. M. Strippoli, MD, PhD, professor of nephrology at University of Bari, Italy, and colleagues.
Using inverse probability weighting approaches, the researchers

Adults with both obstructive sleep apnea and insomnia vs. only obstructive sleep apnea had larger decreases in 24-hour, daytime and nocturnal systolic blood pressure following 4 weeks of CPAP, according to data published in CHEST.
“These findings underscore the potential for a more personalized management strategy for [blood pressure] management in patients with OSA, where the presence of comorbid insomnia may signal a subgroup with a distinct and favorable hemodynamic response to CPAP therapy,” Shuang Li, MD, of Capital Medical University in China, and colleagues wrote.
In a prospective cohort

In U.S. areas with a high prevalence of alpha-gal syndrome, patients with blood type O who received B or AB vs. O plasma/platelets had a significantly greater rate of allergic transfusion reactions, according to study data.
These findings were published in JAMA Internal Medicine.
“We think that all clinicians should be made aware that transfusion-related alpha-gal syndrome (TRAGS) is a possible complication of transfusion,” Richard M. Kaufman, MD, and Nancy M. Dunbar, MD, both professors of pathology and laboratory medicine at Dartmouth’s Geisel School of Medicine, told Healio in a statement.

Black women with endometrial cancer have significantly worse survival than white women, and much of that disparity comes from younger patients.
An analysis of more than 13,000 women showed Black women aged 64 years and younger have a 159% greater risk for death than their white peers, compared with a 56% increased risk for those aged 65 years and older.
The disparity largely stems from younger patients being diagnosed with more aggressive tumors and at later stages.
“We need to give more attention to what’s happening with our younger patients,” Elizabeth J. Suh-Burgmann, MD, gynecologic oncology

Psychiatric disorders present in patients with inflammatory bowel disease both before and after diagnosis, according to a study published in Clinical Gastroenterology and Hepatology.
“Earlier studies have shown an association between IBD and psychiatric disease, but several pressing issues remained,” Jonas F. Ludvigsson, MD, PhD, professor of medical epidemiology and biostatistics at Karolinska Institutet, told Healio. “We wanted to understand when the risk increase for psychiatric disease starts ... how long the risk persisted and if it extended beyond the commonly studied anxiety and

Patients with systemic lupus erythematosus and sustained low hydroxychloroquine blood levels may be at significantly increased risk for atherosclerotic cardiovascular disease, according to data published in Arthritis Care & Research.
“Hydroxychloroquine (HCQ) is the cornerstone of SLE management because it reduces disease activity, prevents flares, limits organ damage accrual and has been associated with cardiovascular protection,” Shivani Garg, MD, PhD, director of the Yale Lupus Program, told Healio. “This study provides hypothesis-generating evidence that optimizing

A 77-year-old stayed awake until exhaustion to escape a nightly banging in her skull. The answer took 15 years and required no drug.