Once-weekly retatrutide induced greater declines in HbA1c and body weight than Ozempic 2 mg for adults with type 2 diabetes, according to topline results from the phase 3 open-label TRASCEND-T2D-2 trial.
As Healio previously reported, the TRANSCEND-T2D-1 trial found that retatrutide (Eli Lilly), a subcutaneous GLP-1, GIP and glucagon triple receptor agonist, reduced HbA1c and body weight more than placebo for adults with type 2 diabetes. In TRANSCEND-T2D-2, 1,298 adults with type 2 diabetes who were unable to achieve glycemic control with metformin with or without an SGLT2 inhibitor were

BOSTON — The “diet battles” are unhelpful and people should focus on eating healthy foods regardless of what diet they belong to, according to a speaker at the Cardiometabolic Health Congress.
“We’re inundated with news, not just in the lay press, but also the scientific press, about this diet vs. that diet,” Lawrence J. Appel, MD, MPH, professor in the Welch Center for Prevention, Epidemiology and Clinical Research at Johns Hopkins University, said during a presentation. “Earlier this year, we published a paper, an update to dietary guidance. And in

PHILADELPHIA — A single infusion of an islet cell therapy induced continued reductions in diabetes distress and hypoglycemia fear at 1 year for adults with type 1 diabetes, according to a presenter.
As Healio previously reported, zimislecel (Vertex Pharmaceuticals) is an insulin-producing islet cell therapy delivered through infusion that restores pancreatic islet cell function, which allows the body to regulate glucose levels. In data presented at the American Diabetes Association Scientific Sessions in 2025, zimislecel demonstrated engraftment and islet function at 1 year in the phase 1 and

Elite athletes from World Wrestling Entertainment experience normal cardiac remodeling associated with intense resistance training, but sex differences were evident, researchers reported.
Some men experienced concentric cardiac remodeling, but did not have pathological hypertrophy, whereas women had larger left ventricular dimensions, according to the results of a study evaluating changes in cardiac structure and function among elite wrestlers published in the Journal of the American Heart Association.
“This study provides novel insights into the cardiovascular phenotype of elite

Older adults with chronic lung disease who received a high dose of the influenza vaccine were hospitalized less often for flu or pneumonia, according to data presented at the European Respiratory Society International Congress.
Although the high dose of the vaccine has been beneficial for older people overall, evidence of its effectiveness among older patients with chronic lung disease has been limited, Lisa Steen Duus, MD, a research fellow at Gentofte Hospital in Copenhagen, and colleagues wrote.
“Flu can be particularly serious for older people with chronic lung disease, such as asthma

NASHVILLE — In this Healio video, Tatyana Kushner, MD, MSCE, discusses a presentation from the GI Ignite session about viral hepatitis in pregnancy at the ACG Annual Meeting.
“It’s an exciting time for viral hepatitis in pregnancy,” Kushner, associate professor of medicine and director of outcomes clinical research in the division of gastroenterology and hepatology at Weill Cornell Medicine, told Healio.
In the early morning session, experts talked about updated guidelines from AASLD/IDSA for hepatitis B and hepatitis C treatment with antivirals in pregnancy.

In pediatric patients with chronic rhinitis, as weekly ambient fine particulate matter exposure went up so did rhinitis symptom severity scores, according to results published in Pediatric Allergy and Immunology.
“These findings support consideration of ambient air pollution as an environmental factor in pediatric rhinitis management,” Rinrada Naka, of the department of pediatrics at Mahidol University in Bangkok, and colleagues wrote.
In a prospective observational cohort study with a median follow-up period of 52 weeks, Naka and colleagues evaluated 146 pediatric patients (mean age, 7.87

More than 60% of women with cancer who completed a 6-week digital cognitive behavior therapy intervention had their insomnia cured at 24 weeks.
Phase 3 randomized trial data, presented at the European Society for Medical Oncology Congress, show the guideline-recommended app Sleepio significantly improved insomnia compared with standard sleep hygiene education, as well as fatigue, depression, anxiety and hot flashes.
“Insomnia in cancer is common and often undertreated,” Donal Brennan, MB, MRCOG, FRCPI, PhD, professor of gynecological oncology at University College Dublin in Ireland, told

NASHVILLE, Tenn. — Patients in the U.S. with primary biliary cholangitis exhibited greater biochemical response and improvement in pruritus with saroglitazar magnesium than non-U.S. patients, according to data presented here.
Despite slightly higher baseline liver enzyme levels for U.S. patients, alkaline phosphatase normalization rates were similar between U.S. and non-U.S. groups.
“Saroglitazar is PPAR-alpha/gamma agonist with an interesting targeting pathway in the pathogenesis of PBC,” Raj K. Vuppalanchi, MD, FACG, director of hepatology at Indiana University School of Medicine, told

Holding biologics or JAK inhibitors for 2 weeks at supplemental COVID-19 vaccine doses fails to improve antibody responses, and increases the odds of inflammatory arthritis disease flare, according to data published in JAMA Internal Medicine.
“Several biologic/targeted synthetic DMARDs used in rheumatology attenuate vaccine immunogenicity,” Jeffrey R. Curtis, MD, MS, MPH, of the University of Alabama at Birmingham, told Healio. “For methotrexate, randomized controlled trial data show that a temporary hold of about 2 weeks improves the humoral response to several vaccines.
“That