DR multiplies risks for glaucoma, ocular hypertension

Patients with type 1 diabetes have over four times the risk for glaucoma and ocular hypertension if they also have diabetic retinopathy, according to data published in Journal of Glaucoma.
Diabetic retinopathy (DR) also more than doubled the risks for both conditions among patients with type 2 diabetes.
“The risk factors for both diabetes mellitus and open-angle glaucoma overlap considerably and include increased age, genetics and ethnic background,” Kaersti L. Rickels, MD, of the department of medicine at University of Wisconsin, and colleagues wrote. “The association between

Walk 8,500 steps per day to maintain weight loss in obesity

Adults with obesity may be able to maintain weight loss by walking about 8,500 steps per day, according to data from a systematic review and meta-analysis that will be presented at the European Congress on Obesity.
In findings that were previously published in the International Journal of Environmental Research and Public Health, researchers analyzed the impact of lifestyle modification across randomized controlled trials conducted among adults with obesity. People who participated in lifestyle modification walked more steps and lost a higher percentage of body weight compared with controls.

Ocrelizumab preserves ambulation, hand function in MS

CHICAGO — Most patients with early active relapsing-remitting MS treated with ocrelizumab did not see worse hand function or ambulation over 6 years, according to data presented at the American Academy of Neurology Annual Meeting.
In fact, more patients saw their symptoms get better instead of worse, Robert A. Bermel, MD, staff neurologist at the Mellen Center for Multiple Sclerosis, Cleveland Clinic, said during his presentation.
“Ambulation and hand function are quite important drivers of disability in MS,” Bermel said. “We know that they’re important to patients. They’re sensitive to

Major adverse limb events higher with radial access in PAD

In patients with peripheral artery disease undergoing revascularization, major adverse limb events were more common with radial access compared with femoral access, driven by target vessel revascularization, a speaker reported.
However, radial access was associated with shorter hospital stays and less use of contrast, the researchers found.
Sameh Sayfo, MD, MBA, FSCAI, interventional cardiologist at Baylor Scott & White The Heart Hospital — Plano, said adverse outcomes related to radial access may be related to lack of operator experience with radial-to-peripheral access for lower extremity

VIDEO: Zasocitinib reduces plaque psoriasis severity up to 24 weeks

DENVER — In this video, Melinda J. Gooderham, MD, MSc, FRCPC, FAAD, discusses two phase 3 trials presented at the American Academy of Dermatology Annual Meeting evaluating zasocitinib for treating moderate to severe plaque psoriasis.
The findings demonstrated that approximately 70% of patients assigned zasocitinib (Takeda) 30 mg achieved a PGA 0 or 1 at week 16, which was maintained up to 24 weeks. Similarly, about 75% of patients treated with zasocitinib achieved PASI 75 at 16 weeks, compared with those assigned apremilast (33%) and placebo (12%). These results were also maintained

Q&A: Predicting how CPAP may impact CVD event risk in OSA

A model made using machine learning can predict if CPAP use in patients with obstructive sleep apnea will benefit or harm their cardiovascular health, according to findings published in Communications Medicine.
Researchers at Mount Sinai developed the model using data from the multinational, randomized controlled Sleep Apnea Cardiovascular Endpoints (SAVE) trial, which included 2,687 adults aged 45 to 75 years with OSA and a history of coronary artery disease or cerebrovascular disease. This study population was also used to test the model.
Patients received an individualized risk prediction

Mental Health Awareness Month: Focus on sleep for peace of mind

National Mental Health Awareness Month, which is observed in May, serves as a good time to remind physicians that sleep can be a major contributor to mental health outcomes.
In an umbrella review published in 2025 in American Journal of Lifestyle Medicine, researchers searched three databases for systematic reviews and meta-analyses on sleep deprivation and health outcomes published between 2008 and 2024. They found 29 studies, of which five focused on mental health.
These studies revealed that sleep deprivation contributed to negative mental health outcomes, including higher anxiety levels,

Extreme heat, asthma-related ED visits linked in children, adults

In pediatric and adult populations, a significant relationship between asthma exacerbations and extreme heat at night and during the day emerged, according to results published in GeoHealth.
“Clinicians who encounter patients with summertime asthma exacerbations should be aware that heat could be responsible for some part of increased risk for those individuals,” Benjamin Zaitchik, PhD, professor of earth and planetary science at Johns Hopkins University, told Healio. “It could also be worth learning from the patients what their home cooling options are and what kinds of temperature conditions

Gastroenterologists, hepatologists at forefront of GLP-1 revolution

Obesity may have met its match in GLP-1 receptor agonists. However, the role of gastroenterologists in obesity management and the administration of this revolutionary class of drugs is complicated and has yet to be defined.
“Gastroenterologists are on the front lines of the obesity epidemic,” Andres Acosta, MD, PhD, associate professor of medicine and consultant in the division of gastroenterology and hepatology at Mayo Clinic and American Board of Obesity Medicine diplomate, told Healio. “We need GIs to embrace the disease and all of its impacts, including GERD, IBD, MASLD, fatty liver

Novel cord blood transplant approach confers ‘remarkable’ outcomes

The addition of an off-the-shelf pooled stem cell product to a single unit of umbilical cord blood conferred favorable outcomes among people with hematologic malignancies, according to phase 2 trial results.
Nearly all treated patients remained alive by data cutoff and none developed severe acute or chronic graft-versus-host disease.
“The outcomes are very solid,” lead author Filippo Milano, MD, PhD, director of the cord blood transplant program at Fred Hutch Cancer Center, told Healio. “I cannot deny that there is always an element of luck when you conduct a clinical trial, but to see results