In patients with moderate aortic stenosis with at least one at-risk feature, transcatheter aortic valve replacement was linked to reduced risk for death or a heart failure event at 2 years compared with clinical surveillance, data show.
“This is going to be a turning point in the way that we see patients with moderate aortic stenosis,” Philippe Généreux, MD, director of the structural heart program at Morristown Medical Center in New Jersey, said during a press conference at TCT 2026.
For the PROGRESS trial, simultaneously published in The New England Journal of Medicine, Généreux and

Long-term levothyroxine therapy after differentiated thyroid cancer may lead to adverse bone outcomes, but more research is needed on other potential adverse effects, according to a review article published in Thyroid.
Fadi Esttaifo, BHSc, MSc, medical student at the University of Ottawa and research assistant at Sunnybrook Research Institute in Toronto, and Mohammad Jay, MD, an endocrinologist, head, neck and adrenal endocrinology clinical fellow and PhD candidate in clinical epidemiology and healthcare research at University of Toronto, said levothyroxine therapy is used long term in some

DENVER — Telitacicept was associated with reduced proteinuria and stabilized kidney function at 2 years vs. placebo for adults with immunoglobulin A nephropathy, according to study data presented at ASN Kidney Week.
Telitacicept (Tai’ai; Yantai Rongchang Pharmaceuticals, RemeGen) is a dual B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) antagonist. It is approved for use to treat systemic lupus erythematosus in China, but is not approved for use in the United States.
Interim analysis of the phase 3 TELIGAN trial showed telitacicept significantly reduced proteinuria

SAN DIEGO — Bemdaneprocel had a favorable safety profile over 4 years of treatment among patients with Parkinson’s disease, according to a poster presented at the 151st Annual Meeting of the American Neurological Association.
Signals also indicated sustained favorable effects, Claire Henchcliffe, MD, DPhil, chair, department of neurology, University of California, Irvine, told Healio.
“The aim of the intervention is very simple conceptually,” she said. “It’s to replace the dopamine inputs in people with Parkinson’s.”
Currently under investigation, bemdaneprocel is a dopaminergic neuron

Traditional Irish dancing wigs may be an overlooked source of traction alopecia in children, according to a case series reporting the experiences of three young dancers who developed patches of hair loss where the hairpieces were secured.
The patients, aged 7 to 8 years, experienced focal hair loss at the vertex of the scalp after wearing the elaborate, tightly curled wigs for high-energy dances during performances and competitions, according to the clinical letter published in Pediatric Dermatology.
One patient wore their wig on two 8-hour occasions in 1 month, another over several days and

The addition of tarlatamab to durvalumab in the first-line maintenance setting improved outcomes for patients with extensive-stage small cell lung cancer.
Results of the randomized phase 3 DeLLphi-305 trial, presented at European Society for Medical Oncology Congress, showed that patients who received the combination exhibited a 58% reduction in risk for death compared with those who received durvalumab (Imfinzi, AstraZeneca) alone.
“The efficacy data are unprecedented,” lead author Jacob M. Sands, MD, associate chief of Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute, told

LAS VEGAS — Healthcare visits may be one of the few opportunities to identify a sex trafficking victim, so it is important for clinicians to be aware of the warning signs, a speaker at OMED said.
In 2025, 21,457 individuals in the United States were victims of sex trafficking, according to the National Human Trafficking Hotline.
Susan Norris, MSEd, founder and executive director of Rescuing Hope, said data indicate over 80% of sex trafficking victims are seen in women’s centers, urgent care or EDs, yet “no one asks the critical questions.”
“Pay attention and look deeper,” she said.
According to

Pennsylvania Gov. Josh Shapiro has signed Elijah’s Law — also known as HB 928 — into law, protecting kids with food allergies in childcare centers by requiring staff to undergo anaphylaxis training and giving them access to epinephrine.
“Pennsylvania’s adoption of Elijah’s Law is an important step toward improving food allergy awareness, preparedness and emergency response in childcare settings,” Ruchi S. Gupta, MD, MPH, medical advisory team member of the Elijah-Alavi Foundation, told Healio.
The bill was sponsored by State Rep. Bridget M. Kosierowski (D-Lackawanna) and State Rep. Kristin

NASHVILLE, Tenn. — Treatmet with obefazimod resulted in clinically meaningful improvements in ulcerative colitis symptoms within 1 week of treatment with increased improvement over time, according to a presentation at the ACG Annual Scientific Meeting.
“[Obefazimod] is an oral agent that is thought to restore mucosal immune balance through regulation of TH-17 cells and activated macrophages, which we know are drivers of active ulcerative colitis,” Bruce E. Sands, MD, MS, FACG, Dr. Burrill B. Crohn Professor of Medicine at Icahn School of Medicine at Mount Sinai, told

Individuals with inflammatory bowel disease who have at least two first-degree relatives with colorectal cancer appear to have the greatest increase in risk for CRC, according to results of a Swedish cohort study.
Analysis also showed that having a relative with early-onset CRC was associated with a more modest risk, a finding that diverges from prior research.
“In an earlier Swedish study, this group was reported to have a ninefold relative risk compared with patients with IBD without such a family history,” Åsa Hallqvist Everhov, MD, PhD, clinical researcher at Karolinska Institutet and