PHOENIX — Tovinontrine increased plasma cyclic guanosine monophosphate levels in patients with HF with reduced or preserved ejection fraction but did not change N-terminal pro-B-type natriuretic peptide levels, a speaker reported.
A post hoc analysis of data indicated a possible inverse dose response relationship with lower-dose tovinontrine (Cardurion Pharmaceuticals) causing less plasma cyclic guanosine monophosphate elevation and greater reduction in NT-proBNP, according to research presented at the Heart Failure Society of America Annual Scientific Meeting.
James E. Udelson, MD, chief of

Editor’s note: This is a developing news story. Please check back soon for updates.
Thomas J. Appio, current Bausch + Lomb chairman of the board, will now also lead Bausch + Lomb as interim CEO, according to a company press release.
Appio first joined Bausch + Lomb in 2010 as managing director, China and took over as president of Bausch + Lomb International in 2016. He transitioned to his role as Bausch Health CEO in 2022 and took over as chairman of the Bausch + Lomb board of directors in August of this year, according to the release.
“The opportunity to lead Bausch + Lomb is both a privilege

NASHVILLE, Tenn. — ACG is addressing AI- and workforce-driven shifts in gastroenterology with investment in biomedical innovation and modernized education initiatives, the outgoing president said at ACG Annual Scientific Meeting.
“While we have all these challenges that we’re facing, I would argue that there’s never been a more exciting time to be a gastroenterologist than now,” William D. Chey, MD, AGAF, FACG, told Healio, reflecting on his address to attendees.
Chey, who also is H. Marvin Pollard Professor of Gastroenterology and chief of the division of gastroenterology and hepatology at

The inclusion of nonlicensed individuals as dialysis technicians into the renal community dates back to the early 1970s.
The Medicare End-Stage Renal Disease (ESRD) Program, passed by Congress in October 1972, resulted in an influx of patients that came with treatment demands that overwhelmed the existing available pool of registered nurses. To meet the demands and avoid treatment rationing, dialysis clinics turned to hiring nonlicensed workers who were provided on-the-job training in cannulation, setting up the machines, treatment monitoring and performing vital signs.
Results from the US

Scores on a clinical evaluation tool for motor symptoms of Parkinson’s disease stabilized with rexaceract, according to data presented at the International Congress of Parkinson’s Disease and Movement Disorders.
In addition to stable scores on the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, oral treatment with the brain-penetrant small molecule also was well-tolerated, Joanne Taylor, PhD, chief scientific officer, Gain Therapeutics, and colleagues wrote.
“The current standard of care for Parkinson’s disease is symptomatic treatment, which is

Latissimus dorsi and teres major tears have emerged as an increasingly recognized source of shoulder pain and performance limitation in baseball pitchers, reflecting the substantial biomechanical demands of modern high-velocity throwing.
The latissimus dorsi originates from the iliac crest, lower ribs and spinous processes of the lower thoracic vertebrae and inserts onto the medial lip of the intertubercular groove of the humerus, often in conjunction with the teres major. The teres major, which runs deep and superior to and can converge with the latissimus dorsi at its insertion onto the

NEW ORLEANS — Instead of treating based on severity, clinicians should match dry eye phenotypes with the appropriate therapy, according to a speaker at Cornea Subspecialty Day at the American Academy of Ophthalmology meeting.
Sorcha Ni Dhubhghaill, MBBCh, PhD, said new research and technology have changed the way ophthalmologists assess and treat dry eye disease.
“It’s now a much richer field, and we can do a lot more,” she said in a presentation. “Recently, TFOS DEWS III has shifted its focus in staging dry eye from being a disease categorized by a severity ladder ... to being a more

The esophageal string test was successful in assessing treatment among adults with eosinophilic esophagitis with no adverse events recorded, according to a study published in Annals of Allergy, Asthma & Immunology.
Current assessments require invasive esophagogastroduodenoscopies (EGDs) performed up to every 8 to 12 weeks, Fouad Moawad, MD, chief of gastroenterology and professor of medicine, Scripps Clinic, and colleagues wrote.
“EGD with biopsy remains the standard for diagnosing EoE, assessing endoscopic features and, importantly, monitoring response to treatment. However, EGDs are

Women who use hormonal contraception may be more likely to initiate semaglutide, according to real-world data from Denmark.
In a nested case-control study presented at the European Association for the Study of Diabetes annual meeting and previously published in JAMA Network Open, nine different hormonal contraception use regimens were associated with increased odds for starting semaglutide (Ozempic/Wegovy, Novo Nordisk). Mille Dybdal Bager, MD, a PhD fellow at Steno Diabetes Center in Copenhagen, Denmark, said the findings highlight how healthcare professionals need to consider a woman’s full

Among patients with COPD and type 2 inflammation at an urgent outpatient visit, the ED or hospital, a single dose of add-on rademikibart vs. placebo lowered treatment failure through 4 weeks, according to phase 2 study topline data.
“Rademikibart significantly reduces the number of patients returning to the hospital or emergency department for additional care in the month following an exacerbation,” Barry Quart, PharmD, CEO and director of Connect Biopharma, said during a webcast.
“In fact, we achieved an 81% reduction in treatment failures, 85% reduction in new moderate to severe exacerbations