Adults with moderate to severe psoriasis and overweight or obesity were more likely to achieve complete skin clearance plus improvement in body weight with combination tirzepatide plus ixekizumab vs. ixekizumab monotherapy, data show.
Data from TOGETHER-PsO — a 52-week, phase 3b, randomized, double-blind, open-label study — demonstrated that participants who received combination therapy with ixekizumab (Taltz, Eli Lilly), an IL-17a inhibitor, and tirzepatide (Zepbound, Eli Lilly), a dual GLP-1/glucose-dependent insulinotropic polypeptide agonist, were more likely to achieve a multicomponent

PHOENIX — Results presented here showed cryopreserved osteochondral allografts had similar outcomes compared with fresh osteochondral allografts in patients with isolated patellofemoral lesions.
“These cryopreserved osteochondral allografts allow the surgeon to have an off-the-shelf option for when they are dealing with these high-level cartilage lesions of the patellofemoral joint, which allows for simpler treatment of patients because they do not have to wait as long to obtain a fresh osteochondral allograft,” Kostas J. Economopoulos, MD, from Mayo Clinic, Arizona, told Healio about results

FORT LAUDERDALE, Fla. — In patients with diabetic macular edema, small gauge pars plana vitrectomy should be considered as a first-line treatment, according to a speaker at Retina World Congress.
“The burden of injection today is almost impossible to follow,” Matias Iglicki, MD, said during a presentation. “We have to do something now before we face the consequences.”
Iglicki and colleagues aimed to investigate the visual and anatomic outcomes of small gauge pars plana vitrectomy (PPV) through 24 months for patients with treatment-naïve DME. The multicenter study analyzed 120 eyes across 120

The U.S. Supreme Court on Thursday ruled that mifepristone can continue to be dispensed via mail as the legal battle over its use proceeds in the lower courts, documents show.
Two Supreme Court Justices, Samuel A. Alito Jr. and Clarence Thomas, dissented while the majority did not explain their ruling.
On May 1, the 5th U.S. Circuit Court of Appeals temporarily stopped mail-order mifepristone access, requiring it to be dispensed in person.
As Healio previously reported, the case was filed against the FDA by the state of Louisiana and a woman who alleged she was pressured into taking “abortion

NEW ORLEANS — Transplant social workers identified top risk factors and psychosocial interventions needed for evaluating kidney transplant candidacy, according to data presented at the National Kidney Foundation Spring Clinical Meetings.
At the Society for Transplant Social Workers (STSW) annual meeting in 2024, members acknowledged the lack of standardization in psychosocial assessments for transplant candidacy and limited voice of social workers in related research, according to Lara Tushla, LCSW, NSW-C, FNKF, CCTSW, a kidney and pancreas transplant social worker at Rush University Medical

The American Academy of Pediatrics released its first clinical practice guideline on faltering weight — formerly known as failure to thrive — with advice for diagnosing and treating the condition.
The AAP teamed up with the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition nearly a decade ago to create an evidence-based guideline for pediatricians, according to Hans B. Kersten, MD, FAAP, chair of the AAP’s guideline panel on faltering weight.
“There were a number of different goals that we had,” Kersten told Healio. “First was ... a new name.” [Editor’s note:

In the first trial of microRNA inhibition to treat heart failure, a novel agent did not reduce left ventricular end-systolic volume index at 6 months compared with placebo in patients with HF and recent MI, researchers reported.
However, the agent, CDR132L (Novo Nordisk/Cardior Pharmaceuticals), will be evaluated for other indications, a researcher told Healio.
For the HF-REVERT trial, presented at Heart Failure 2026 and simultaneously published in Nature Medicine, the researchers randomly assigned 294 patients with recent MI and LV systolic dysfunction to CDR132L 5 mg/kg, CDR132L 10 mg/kg or

A digital weight management program reduced “food noise” for adults with obesity, with greater benefits observed among adults using a GLP-1 receptor agonist, according to data presented at the European Congress on Obesity.
In a poster, Hanim Ecem Diktas, PhD, postdoctoral researcher at Pennington Biomedical Research Center of Louisiana State University, and colleagues described food noise as persistent, intrusive thoughts about food that are disruptive to daily life. The researchers wrote that anecdotal reports have indicated GLP-1s may reduce food noise. In an observational cohort study,

Having a prior heart attack was associated with excess yearly decline in cognitive function, a predictor of future dementia, according to data published in Stroke.
The impact of prior MI on cognitive function was consistent regardless of whether participants self-reported their clinical history or were unaware of their prior MI, researchers reported.
“As people age, the risk of cognitive issues and dementia increases, and some people may be at higher risk of cognitive decline,” Mohamed Ridha, MD, assistant professor of neurology at Ohio State University, said in a press release. “Our

The monoclonal antibody burosumab improved multiple biochemical measures and patient-reported outcomes among children and adults with X-linked hypophosphatemia, according to real-world data.
As Healio previously reported, the FDA approved burosumab-twza (Crysvita, Kyowa Kirin) in April 2018 as the first therapy to treat X-linked hypophosphatemia, a form of rickets that causes low phosphorus levels. Leanne M. Ward, MD, FRCPC, research chair and professor of pediatrics at University of Ottawa in Canada, said it was important to conduct a study assessing real-world benefits beyond phosphorus