In this video, Sunir J. Garg, MD, FACS, FASRS, talked about a post hoc analysis of pegcetacoplan clinical trials in geographic atrophy presented at the American Society of Retina Specialists annual meeting.
Garg, chief of the retina service at Wills Eye Hospital and professor of ophthalmology at Thomas Jefferson University, said the results of this analysis of Syfovre (pegcetacoplan injection, Biogen) can help determine which patients would benefit the most from treatment as well as help explain to patients their rate of change before vs. after starting treatment.
“I think that would be really

Many experts agree that polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome, better reflects the hormonal and metabolic aspects of the condition.
But some argue that PMOS still falls short in becoming a comprehensive moniker for the complex syndrome.
Anuja Dokras, MD, MHCI, PhD, director of the Penn Polyendocrine Metabolic Syndrome Center and Founder’s Professor of Women’s Health at the University of Pennsylvania, was one of the senior authors of the initial paper that announced the name change in The Lancet. She told Healio that PCOS “was problematic” for two

Yvonne “Bonnie” A. Maldonado, MD, called the two measles-related deaths announced this week in Pennsylvania “the canary in the coalmine.”
“We should be at the point where vaccine-preventable diseases and deaths should not be occurring,” Maldonado, the Taube Endowed Professor of Global Health and Infectious Diseases at Stanford University School of Medicine, told Healio.
But with the Trump administration’s push to overhaul childhood vaccination guidelines, experts such as Maldonado worry about continued preventable threats to the health and safety of children.
In the latest move, HHS announced a

Rehabilitation after a stroke should begin soon after the patient is stable and should be personalized to include physical, cognitive and mental health, according to the 2026 Guideline for Adult Stroke Rehabilitation and Recovery.
“It’s been 10 years since the last guidelines came out. There has been a lot of research in rehabilitation and medicine since that time,” Lorie Gage Richards, PhD, FAHA, chair of the volunteer guideline writing group, told Healio.
“It’s necessary to regularly update guidelines so that they reflect the latest evidence for clinical practice,” said Richards, who also is

Earlier successful discontinuation of continuous renal replacement therapy may provide benefits for patients with preserved urine output, according to study data published in the Clinical Journal of the American Society of Nephrology.
Continuous renal replacement therapy (CRRT) can be a lifesaving but invasive procedure, highlighting a need to determine optimal timing for a liberation trial — an attempt to discontinue therapy without needing to restart it, according to Dana Y. Fuhrman, DO, MS, associate professor of pediatrics in the division of critical care medicine at the University of

Use of active surveillance for early prostate cancer increased sharply in the VA healthcare system over the past couple decades, according to a research letter published in JAMA.
Adoption of the approach tripled among men with low-risk prostate cancer and quadrupled among those with favorable intermediate-risk disease.
“Active surveillance means patients can manage their low-risk cancer without upfront radical prostatectomy or radiation therapy, which can result in treatment-related morbidity that significantly affects quality of life,” lead author Grace Lee, MD, resident physician in urology

A proposed CMS rule codifying the Medicare Drug Price Negotiation Program could result in “unintended consequences” for physician practices and treatment access, according to a statement from the American College of Rheumatology.
In its statement, addressed to CMS Administrator Mehmet Oz, MD, the ACR warned that the new round of Medicare drug price negotiations may “inadvertently” restrict access to Part B treatments administered in a physician’s office or other outpatient setting.
“ACR’s comments are primarily intended to help CMS understand

Taking aspirin alone after total joint arthroplasty may be a noninferior alternative for preventing venous thromboembolism compared with rivaroxaban then aspirin, according to results.
“The message of the safety and efficacy of aspirin alone in patients undergoing hip and knee arthroplasty is a very reasonable one, and now we have evidence to back that up,” Sudeep Shivakumar, MD, a hematologist in the division of hematology and hematologic oncology at Dalhousie University in Halifax, Nova Scotia, told Healio. “There was no increase in bleeding events, and there was no difference in deaths. Our

Adults with Graves’ disease and lower thyrotropin receptor antibody levels may be able to discontinue antithyroid drug therapy after less than 1 year without additional risk for relapse, according to data published in Thyroid.
“Current guidelines generally recommend 12 to 18 months of antithyroid drug therapy for Graves’ disease, irrespective of disease severity,” Salman Razvi, MD, FRCP, clinical senior lecturer and consultant in the Translational and Clinical Research Institute at Newcastle University in the U.K., told Healio. “However, many patients with milder disease achieve biochemical

Pharmaceutically manufactured CBD reduced patient-reported pain scores and lowered inflammatory markers in patients with recurrent pericarditis, according to data published in the Journal of the American Heart Association.
THC-free CBD (CardiolRx, Cardiol Therapeutics) was well tolerated and may serve as an effective adjunctive therapy for patients with symptomatic recurrent pericarditis, researchers reported.
“Pharmaceutically manufactured cannabidiol is an oral formulation that inhibits NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 inflammasome activation and