In developing immunity to allergens, a little ‘dirty’ goes a long way

Conventional wisdom has held for some time that children who grow up in environments rich with biodiversity—farms, homes with pets, rural settings in general—are less likely to have allergies. The thing nobody has ever completely understood is why? Yale researchers have now found an answer. It turns out that exposure to diverse microbes and proteins early in life creates broad immune memory and a specific antibody that helps block allergic reactions later in life. Rather than overreacting to harmless allergens (ragweed, cats, peanuts, etc.), researchers say, an experienced immune system responds in a balanced way.

Perceiving nature in daily life and exercise linked to better mental health

Is living in a leafy neighborhood enough to improve your mental health? Not necessarily. What matters most is frequent exposure to nature across different settings, especially while being physically active. That's the takeaway from a study led by Université de Montréal postdoctoral fellow Corentin Montiel, supervised by professor Isabelle Doré of UdeM's School of Kinesiology and Physical Activity Sciences and School of Public Health.

Study maps 30 rheumatoid arthritis biopsies, linking joint scarring to treatment resistance

Rheumatoid arthritis (RA) is a common autoimmune disease where the body's immune system mistakenly attacks the lining of its own joints, causing chronic pain, swelling, and stiffness. While there have been remarkable advancements in the treatment of RA with an array of therapies that target inflammation, a large subset of patients (approximately 6–28%) continue to experience difficult-to-manage symptoms of disease even after receiving multiple lines of treatment.

Study finds comparable long-term survival between 2 leading multi-arterial coronary artery bypass grafting strategies

A late-breaking study drawing on more than 15 years of national outcomes data from the STS Adult Cardiac Surgery Database (ACSD) suggests that the two most commonly used multi-arterial coronary artery bypass grafting (CABG) strategies—bilateral internal thoracic artery (BITA) and single internal thoracic artery plus radial artery (SITA+RA)—offer comparable long-term survival overall, with important differences emerging by patient age.

Gut-derived metabolite hippuric acid ‘turns up’ immune inflammation, study finds

Scientists at The Wistar Institute have identified a previously overlooked mediator in the body's response to life-threatening infections: hippuric acid, a metabolite produced when gut bacteria break down polyphenols from berries, tea, and other plant-based foods. The research reveals that this molecule acts as an immune-system amplifier, boosting the body's inflammatory defenses during early infection but elevating them to deadly levels when infections progress to sepsis.