Incarcerated people in U.S. jails and prisons have limited access to regular isotretinoin therapy for conditions like severe acne conglobata or treatment-resistant dissecting cellulitis, researchers reported.
“The United States has about 2 million people in jail or prison at any point,” Joerg Albrecht, MD, PhD, a dermatologist for Cook County Health, which serves the Cook County Jail in Chicago, told Healio. “That is not a small number, so there are certain responsibilities that come with that.”
The iPLEDGE Risk Evaluation and Mitigation Strategy program, run by a private group and overseen by

Fracture-related infection is a frequent and costly complication after fracture fixation, with previously published literature citing a wide range in incidence from as low as 1% in closed fractures to as high as 30% in severe open injuries.
While fracture-related infections can be similar to periprosthetic joint infections, Ashley E. Levack, MD, MAS, FAAOS, said there are important differences between the two.
“The host matters a lot,” Levack, associate professor of orthopedic surgery at Loyola University Medical Center and Stritch School of Medicine, told Healio. “In

An 80-year-old man was referred for gradual worsening vision loss in his right eye.
Specifically, he noted having to actively look downward to avoid tripping due to loss of inferior peripheral vision. These symptoms developed gradually over the past 1 to 2 months. He also reported seeing intermittent flashes and a transient blue discoloration whenever transitioning from a dark to light environment.
He denied headaches, scalp tenderness, jaw claudication, weight loss or pain with eye movement. His diet was well balanced, and he had not undergone recent surgeries.
Approximately 25 years prior, the

Vogt-Koyanagi-Harada syndrome is an autoimmune granulomatous inflammatory disorder targeting melanocytes in the uveal tract, meninges, inner ear and skin.
The disease typically progresses through prodromal, acute uveitic, convalescent and chronic recurrent stages. Delayed or inadequate treatment may result in chronic inflammation and vision-threatening complications such as choroidal neovascular membrane.
The management of Vogt-Koyanagi-Harada (VKH) syndrome becomes significantly more complex in patients with systemic comorbidities such as diabetes. Corticosteroids remain the mainstay of

WASHINGTON — Pain management for intrauterine device insertions is highly inconsistent, but patients should be offered “a platter” of options, according to research presented at ACOG’s annual meeting.
Despite recent guidance, the standard of care for IUD placement is widely variable, Mack Goldberg, MD, an assistant professor of obstetrics and gynecology at Vanderbilt University, and colleagues wrote.
“One of our graduated residents I mentored, Erin Vrana, MD, wanted to examine what pain control options are available for our patients after doing research on new lidocaine options available in the

Advanced cardiovascular-kidney-metabolic syndrome was associated with increased risk for incident cancer among a large cohort of Japanese adults, according to data published in Circulation: Population Health and Outcomes.
These results demonstrate the importance of risk assessment outside of CV and kidney outcomes in patients with cardiovascular-kidney-metabolic (CKM) syndrome, researchers reported.
“CKM syndrome represents a complex interplay among the cardiovascular, kidney and metabolic systems, where dysfunction in one area may trigger or exacerbate dysfunction in others,”

Until recently, diagnostic tests for confirming Alzheimer’s disease pathology have only included brain positron emission tomography imaging or cerebrospinal fluid analysis.
Although highly accurate, these tests remain out of reach for many patients and even some specialized clinics due to high cost or limited availability. As a result, a critical gap persists in the availability of accessible and scalable biomarker tests.
At the same time, the Alzheimer’s treatment landscape has entered a new era with the approval of treatments that target the underlying biology of the disease, including

LAS VEGAS — A daily oral therapy reduced insulin-like growth factor I levels and improved symptoms in a real-world setting among adults with acromegaly, according to a presenter.
As Healio previously reported, the FDA approved paltusotine (Palsonify, Crinetics) in September as the first once-daily oral therapy to treat acromegaly. During a talk at the American Association of Clinical Endocrinology Annual Scientific and Clinical Conference, Leena Shahla, MD, medical director at Duke Pituitary Center, associate professor of medicine and associate professor of neurosurgery at Duke University,

DENVER — In this video, Lawrence F. Eichenfield, MD, discusses topical 0.05% roflumilast for infants and young children, from his presentation at the American Academy of Dermatology Annual Meeting.
According to Eichenfield, there are few topical corticosteroids or nonsteroids approved for those aged under 2 years with atopic dermatitis. For this study, researchers evaluated roflumilast in children aged 3 months to 2 years with mild to moderate AD. The findings demonstrated that 49% of patients achieved clear or almost clear skin after 4 weeks of treatment, with 98% tolerance and very

Among adults with obesity, the risk for new physician-reported sleep apnea and new-onset obstructive sleep apnea significantly fell if they used vs. did not use a GLP-1 agonist, according to data from two studies.
Both studies were published in Annals of the American Thoracic Society.
“Our results suggest that these classes [GLP-1/dual agonists] may be beneficial for preventive strategies aimed at reducing the incidence of sleep apnea in a real-world setting,” Beatriz S. Prado, of the cardiology center at Hospital Sírio Libanês in Sao Paulo, and colleagues wrote.
Authors of the other study led