Researchers have developed a targeted fibrosis screening strategy that reduces the number of adults flagged for testing, doubling case detection while maintaining low risk for future liver disease in those not eligible for screening.
Current guidelines from AGA, American Association for the Study of Liver Diseases and European Association for the Study of the Liver identified 60% to 76% of the U.S. population as eligible for fibrosis screening.
“The major issue with current recommendations is that they are overly broad,” lead study author Laurens A. van Kleef, MD, PhD, a postdoctoral researcher

The WHO 2019 report on vision estimates that 36 million people in the world are blind and another 217 million have moderate to severe visual impairment.
The International Agency for the Prevention of Blindness states that 1.1 billion of the world’s 8 billion people suffer from visual impairment.
About 90% of people with vision impairment live in lower-income developing nations, and the likelihood of becoming blind during one’s lifetime is 10 to 15 times higher in a low-income emerging country than in a high-income country. This disparity is increasing rather than decreasing at the

People who pursue semi-retirement with a different employer experienced less cognitive decline compared with those who stayed with the same employer and those who pursued full retirement, according to a speaker.
Gradually leaving the labor force instead of suddenly ending employment may have a “protective effect” on cognition, Wei Yang, PhD, director of Institute of Gerontology at King’s College London, said during her presentation at the Alzheimer’s Association International Conference.
“People who have changed companies, they are likely to have to learn new skills, to adapt to a new

Longer-term dual antiplatelet therapy with clopidogrel and aspirin prevented ischemic events without raising bleeding risk in a cohort of Chinese patients with multivessel coronary artery disease who had a stent implant, data showed.
In certain populations with high ischemic risk and low bleeding risk, extended DAPT after percutaneous coronary intervention may be a therapeutic option compared with aspirin monotherapy, according to the results of DAPT-MVD published in The New England Journal of Medicine.
“Most recent studies done in the last decade have actually been looking to shorten DAPT, to

CHICAGO — Neurological and pancreatic complications are common in patients with congenital hyperinsulinism, according to a systematic review presented at ENDO 2026.
“The goal of this work was to systematically synthesize the [congenital hyperinsulinism] literature and critically evaluate evidence that is often cited but derived from relatively small studies,” Brian K. Roberts, MD, chief medical officer of Rezolute, which is developing ersodetug for treatment of hyperinsulinism, told Healio. “We wanted to better understand the strength and consistency of the published data, align on definitions

An investigational vaccine that targets common KRAS mutations induced durable immune responses among individuals at high risk for pancreatic cancer, results of a phase 1 clinical trial showed.
Eighteen of 20 participants achieved KRAS-specific T-cell responses. Several individuals had either complete radiographic resolution or regression of pancreatic cysts, and none developed pancreatic cancer by data cutoff.
The vaccine also appeared safe, according to researchers, with no grade 3 or higher adverse events reported.
“Despite tremendous efforts, we have yet to develop a way to identify

Vascular disease severity and intestinal pseudo-obstruction predicted lower BMI and possible malnutrition in patients with early systemic sclerosis, according to data published in Arthritis Care & Research.
“Malnutrition is common yet underrecognized in systemic sclerosis,” Zsuzsanna McMahan, MD, MHS, co-director of the UTHealth Houston Scleroderma Center, and associate professor of medicine in the division of rheumatology at the McGovern Medical School at the University of Texas Health Science Center, told Healio. “Although BMI is routinely used in clinical practice, there has been