Over the past 75 years, rheumatology has helped define modern clinical immunology. Yet for much of that history, the average practicing rheumatologist did not need an extensive working knowledge of immunologic mechanisms to care for patients.
We treated inflammatory arthritis with gold salts, penicillamine, nonsteroidal anti-inflammatory drugs and eventually methotrexate. Although remarkable advances in basic and translational immunology were occurring, they remained largely the domain of investigators.
That changed with the arrival of biologic therapies in the late 1990s. Suddenly, every

A fecal immunochemical testing-based screening program in Spain was linked to durable decline in colorectal cancer mortality over a 21-year period, according to study results published in JAMA Network Open.
“Our research was motivated by a key clinical challenge: the need to generate long-term, population-level evidence on the real impact of organized FIT-based colorectal cancer screening programs on mortality,” Luis Bujanda, MDPhD, professor of medicine at Donostia University Hospital in San Sebastián, Spain, told Healio. “Although FIT screening is widely implemented, robust data describing

The 2025 National Survey on Drug Use and Health indicated decreases in rates of adolescents aged 12 to 17 years who engaged in suicidal thoughts and behavior between 2021 and 2025.
According to the Substance Abuse and Mental Health Services Administration (SAMHSA), these decreases include 12.9% to 10.4% for serious thoughts of suicide, 6.2% to 5.1% for making a suicide plan, and 3.6% to 2.9% for suicide attempts.
However, Rebecca J. Shields, DO, child and adolescent psychiatry specialist at State University of New York Upstate Medical University, said that more work needs to be done to mitigate

The U.S. End-Stage Renal Disease program is extraordinary in the history of American medicine.
In 1972, Congress extended Medicare coverage to people with kidney failure requiring dialysis or transplantation, regardless of age, creating a uniquely broad federal entitlement for treatment of a specific chronic disease with no cure.
This societal commitment has saved and sustained millions of lives. Yet it has also produced a striking paradox: The United States operates one of the world’s most expensive dialysis systems while often remaining relatively slow to adopt technologic advances and

Fracture incidence for adults with type 1 diabetes is higher than those without diabetes, and rises as severity of diabetic kidney disease worsens, researchers reported in Diabetes Care.
“Fracture risk in individuals with type 1 diabetes begins in youth and increases substantially with the development of diabetic kidney disease,” Maija Feodoroff, MD, PhD, visiting researcher in the Folkhälsan Research Center at University of Helsinki and Helsinki University Hospital in Finland, told Healio. “These findings suggest that bone health should be considered an integral part of long-term diabetes

Adult e-scooter riders were 3.45 times more likely than motorcycle riders and 1.74 times more likely than bicycle riders to experience a traumatic brain injury, according to study findings published in Scientific Reports.
Risks for TBI similarly increased for children who rode e-scooters as well, David Bodansky, BMedSc, MBChB, specialist hand and wrist orthopedic surgeon at Chelsea and Westminster Hospital NHS Foundation Trust, and colleagues wrote.
“In 2020, I was working at Aintree University Hospital, the major trauma center in Liverpool, and saw repeated injuries from e-scooter riders —

Adults with OSA nonadherent to positive airway pressure therapy and who did not have cardiovascular disease had a reduced risk for diabetes and hypertension 2 years after hypoglossal nerve stimulation implantation, according to study data.
These results were published in JAMA Otolaryngology-Head & Neck Surgery.
“Our findings in this cohort study indicate variable but potential longer-term cardiovascular benefits of [hypoglossal nerve stimulation], which may inform discussions between clinicians and patients,” Neil Kondamuri, MD, otolaryngology resident at the University of Chicago Medicine,

The FDA has granted fast track designation to PVX108, an immunotherapy comprising seven synthetic peanut-peptide fragments, according to a press release.
As Healio previously reported, the peptides in PVX108 (Aravax) represent four immunodominant CD4+ T-cell epitopes in Ara h 1 and three from Ara h 2.
“PVX108 contains peptides which target the T cells [that] play a pivotal role in regulating allergic disease but are too small to cross-link IgE on the surface of mast cells, which is the primary trigger for acute allergic reactions,” Pascal Hickey, PhD, CEO of Aravax, told Healio. “It therefore

Colorectal cancer mortality fell 50% over 21 years among individuals aged 50 to 69 years in a rural region in Spain, coinciding with the implementation of a population-wide fecal immunochemical test-based screening program.
A retrospective analysis of more than 2 million individuals living in the Basque Country of Spain, showed more than 70% of eligible residents participated in the program, resulting in approximately 4,700 colorectal cancer diagnoses, most of which clinicians categorized as stage I or II.
“No country should be without a colorectal cancer screening program,” Luis Bujanda, MD,

Eyes from Greenland sharks more than a century old showed no obvious retinal degeneration, an animal finding that does not yet apply to human vision.