Study shows proof-of-concept for nipocalimab in lupus

The neonatal Fc receptor blocker nipocalimab exhibited significant improvement over placebo in systemic lupus erythematosus at 24 and 52 weeks, according to data presented at the EULAR 2026 Congress.
“Especially in lupus, IgG antibodies can be pathogenic,” said Richard A. Furie, MD, of the division of rheumatology at Northwell Health.
Furie additionally noted that IgG antibodies “provoke inflammation,” participate in the formation of circulating immune complexes and cause cellular cytotoxicity via several different mechanisms.
“These are pathogenic antibodies that we would love to eliminate,” he