“The Pitt” broke down a common misconception about penicillin allergy in season two, episode six.
In this episode, third-year medical student Joy Kwon points out that a patient has a penicillin allergy, but nurse Kim Tate lets her know his PEN-FAST was negative and gives him cefazolin.
Data on the development and validation of the PEN-FAST algorithm were published in JAMA Internal Medicine in 2020. The tool considers four factors to determine a patient’s risk for true penicillin allergy: time since reaction (5 years or less), history of anaphylaxis or angioedema, severe cutaneous adverse

Genetic risk for inflammatory bowel disease could also help identify which patients will have a more severe disease trajectory.
An evaluation of more than 8,000 Danish individuals with IBD found those with the highest number of loci associated with ulcerative colitis and Crohn’s disease had a significantly higher likelihood of being hospitalized, requiring major surgery and needing treatments, including systemic corticosteroids.
"We are gradually, step by step, getting closer to the point where we can offer more individualized care to patients,” senior author Tine Jess, MD, DMSC, professor and

Prescriptions for an adalimumab biosimilar among new users rose from 0% to 24% after CVS Caremark added it to its formulary, but then fell to 10% 1 month later, according to data published in Arthritis Care & Research.
“Adalimumab is the highest-grossing drug in history, and legal battles delayed the market launch of biosimilar competition by about 6 years,” Eric T. Roberts, PhD, MPH, of the University of California San Francisco, told Healio. “Understandably, the community was extremely excited about the potential for cost savings when biosimilars finally did launch in 2023. However, that