Biomarkers could improve depression diagnosis

Neuroscientists at the University of New England (UNE) have found three distinctive brain patterns shared by people with childhood maltreatment and depression that could provide the launching pad for a new approach to diagnosis and treatment.

How your neighborhood could be aging you

There's a growing consensus that your ZIP code is a strong predictor of your health and lifespan. Now, researchers at NYU School of Global Public Health have determined that neighborhood conditions may be driving aging at the cellular level. Their study, published in Social Science and Medicine, finds that people living in neighborhoods with fewer social and economic opportunities such as jobs and stable housing are more likely to have an abundance of CDKN2A RNA, a measure of cellular aging.

Study predicts HIV infections could rise 10% if CDC testing funds end

Timely HIV diagnosis and treatment are critical to preventing transmission. To help make this happen, the U.S. Centers for Disease Control and Prevention (CDC) provides funding for HIV testing to local health departments and community organizations. In a new NIH-funded Johns Hopkins Medicine study, researchers used a computer model to quantify the effect of funding cuts for HIV testing. They estimate that HIV infections could increase an average of 10% in 18 U.S. states if this funding is interrupted or ended.

What is muscle memory, and can I improve mine?

Whether it's riding a bike or knitting a sweater, there are some tasks you do without thinking. These are commonly associated with "muscle memory," the idea your body can remember how to perform complex tasks and, over time, learn to do them automatically.

How childhood dementia begins in brain cells

An Australian-led international research collaboration has delivered a promising breakthrough in the quest to better understand and treat childhood dementia. Recently published in the journal Nature Communications, the study uncovered a fundamental mechanism underlying Sanfilippo syndrome, a common form of childhood dementia, revealing how hyperactive and dysregulated synaptic circuits emerge in the brain tissue of children impacted by this devastating disease.

Molecular map could unlock new treatments for heart and lung diseases

Scientists have created a new "molecular map" uncovering how an important human receptor involved in blood clotting and inflammation works—an advance that could help us design better drugs for conditions such as pulmonary arterial hypertension, cardiovascular disease, and certain cancers. The study, led by an international team including researchers from Trinity College Dublin and published in Nature Communications, used advanced cryo-electron microscopy to capture high-res images of the thromboxane A2 receptor while it was active and primed to send signals across the membrane to the cell interior.

Uptake of new Medicare G2211 code slower than projected by CMS

A retrospective study of outpatient visits found that use of the Centers for Medicare & Medicaid Services (CMS) G2211 add-on code has grown steadily since inception in 2024 but remains well below federal expectations. By mid-2025, the code appeared on about 27% of outpatient Medicare evaluation and management visits, short of early projections that more than one-third of such encounters would qualify.

Scientists reveal a new way cancer cells survive DNA damage

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered that the enzyme Pol theta (Polθ) drives a DNA repair mechanism directly at broken replication forks—one of the most frequent forms of DNA damage in cancer cells. The findings, published in Molecular Cell on March 16, 2026, help explain how tumors survive relentless replication stress and clarify why Pol theta inhibitors may be an effective strategy to selectively target cancer.