You check your smartwatch after a run. Your fitness score has dropped. You've burned hardly any calories. Your recovery score is really low. It's telling you to take the next 72 hours off exercise.

Scientists at St. Jude Children's Research Hospital have found that they can reverse the effects of HNRNPH2-related neurodevelopmental disorder using antisense oligonucleotides (ASOs) in preclinical models. ASOs are short synthetic nucleic acid strands that target specific messenger RNA. In work published in Science Translational Medicine, the researchers show that ASOs block production of the aberrant HNRNPH2 protein. This consequently boosts expression of the closely related HNRNPH1 protein, reducing multiple symptoms of the disorder. The work provides vital mechanistic data to support the advancement of this promising therapy to clinical studies.

A research team at the University of Cologne's Center for Molecular Medicine Cologne (CMMC) has discovered that the protein cFLIP can be used to override the defenses of Diffuse Large B Cell Lymphoma (DLBCL) against programmed cell death. These defenses often cause treatments to be ineffective because they allow the cancer cells to survive. The results are especially relevant to ABC-DLBCL, a specific subtype of blood cancer that has poor patient prognosis and survival outcome. The new study appeared under the title "Expression of cFLIP in B cells is essential for diffuse large B cell lymphoma pathogenesis" in the Blood Journal.

A research team has, for the first time, identified at the cellular level why the olfactory system is the first to be damaged in the early stages of Alzheimer's disease (dementia). The paper is published in the journal Alzheimer's & Dementia. The team was led by Prof. Moon Cheil of the Department of Brain Sciences at the Daegu Gyeongbuk Institute of Science and Technology, in collaboration with a team led by Prof. Ali Jahanshahi at Maastricht University in the Netherlands.

Researchers updated the global catalogue of human-infective RNA viruses to 239 ICTV-recognised species, incorporating taxonomy, discovery dates, locations, genome links, host range, transmissibility, and transmission routes. The dataset shows that most known human-infective RNA viruses remain strictly zoonotic, while only a minority are endemic in humans or capable of epidemic spread.

A cross-sectional study of 97 women with infertility found that higher vitamin E intake was associated with lower prolactin levels and smaller hip circumference. Riboflavin and calcium intake were linked to higher muscle mass percentage, but the findings are association-based and need confirmation in longitudinal studies.

Essay challenges the scientific validity of the Blue Zones concept and Ancel Keys’ Lipid Hypothesis, arguing that both rest on biased data, weak records, and methodological flaws. The authors say some longevity claims may reflect clerical errors, poverty, and unreliable vital records rather than uniquely healthy lifestyles.

A randomized controlled trial protocol will test whether the cardiometabolic risks linked to ultra-processed foods stem from industrial processing, poor nutrient composition, or both. Using four controlled diets, researchers will separate the effects of UPF content from saturated fat, added sugar, and sodium on LDL cholesterol, insulin resistance, and blood pressure.

The expanding use of robotic technology in lung transplantation came under scrutiny at today's 46th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), where experts debated whether its clinical benefits justify the cost and complexity.

Advances in pediatric heart care are helping more children survive long enough to receive a transplant-but a critical shortage of donor hearts means too many are still dying while they wait, experts warned today at the International Society for Heart and Lung Transplantation (ISHLT) 46th Annual Meeting and Scientific Sessions.