Creatine improves physical performance but does not necessarily reduce inflammation, finds study

Creatine, one of the most popular supplements among gym-goers and athletes, does not appear to have the anti-inflammatory effect that many imagine. This conclusion comes from a systematic review and meta-analysis conducted in Brazil by researchers at São Paulo State University (UNESP), which evaluated clinical trials in humans. The study indicates that, to date, there is no consistent evidence that creatine reduces inflammatory markers in the body.

Family-donor stem cells show safe symptom relief for ‘butterfly skin’ patients, trial suggests

The intravenous infusion of mesenchymal stem cells from family donors is safe and improves symptoms such as pruritus (itching), sleep disturbances, and fatigue associated with Recessive Dystrophic Epidermolysis Bullosa (RDEB), popularly known as "butterfly skin." This is one of the primary conclusions of a clinical trial conducted by researchers from the Universidad Carlos III de Madrid (UC3M), the Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) of the Ministry of Science, Innovation and Universities, the Fundación Jiménez Díaz Health Research Institute (IIS-FJD), the CIBER Rare Diseases (CIBERER), and the La Paz University Hospital in Madrid.

Long-term trial challenges assumptions about lymph node radiation therapy in breast cancer

Final results from a landmark EORTC randomized trial with more than 20 years of follow-up show that irradiation of the internal mammary and medial supraclavicular lymph nodes reduces breast cancer mortality but does not improve overall survival. The findings highlight the importance of very long-term follow-up when evaluating cancer treatments, particularly in patients with an otherwise favorable prognosis.