A protocol for deprescribing inappropriate medications for patients on hemodialysis was feasible and well received, according to study data.
However, nephrologists who participated in the study said the deprescribing process may be difficult to integrate into their clinical workflow.
Inappropriate medications, such as gabapentinoids and muscle relaxants, are commonly prescribed to older adults on hemodialysis but can lead to adverse events, such as falls, extreme drowsiness, confusion, hospitalization and mortality, Rasheeda Hall, MD, MBA, MHS, associate professor of medicine and population

Weight loss alone does not explain all of the cardiovascular benefits observed with semaglutide 2.4 mg in the SELECT trial, according to an analysis published in the European Heart Journal.
“Several major trials have established that GLP-1 receptor agonists reduce serious cardiovascular disease, primarily in people with type 2 diabetes. SELECT was the first trial to show that these drugs can also lower cardiovascular disease in people who did not have diabetes,” Helen M. Colhoun, MD, FRCP, professor and AXA chair in medical informatics and life course epidemiology at the University of

In this Putting It Into Practice column, Jonathan D. Leffert, MD, FACP, MACE, ECNU, talks with Yul D. Ejnes, MD, MACP, FRCP (Lon.), a recent retiree, about what employed physicians should know about the business of practicing medicine.
Leffert: From your perspective as a physician formerly in private practice and now recently retired from an employed position in a large practice, tell us about an optimal workload from the number of patients seen per day, the number of days per work and the protected time allotted.
Ejnes: I prefer to frame “workload” in terms of how many patients are taken

Patients with asthma and COPD using at least three short-acting bronchodilators canisters a year vs. none had an elevated risk for cardiovascular events and all-cause mortality, according to data published in ERJ Open Research.
“For the everyday clinician, these findings show the importance of closely monitoring the overuse of short-acting bronchodilators in both asthma and COPD patients and assessing cardiovascular risk,” Lies Lahousse, PharmD, PhD, associate professor at Ghent University, told Healio. “Given it is a marker of poor disease control, it also requires reassessing adherence and

SAN DIEGO — Children of parents reporting household tobacco and e-cigarette use vs. no use had higher odds for poor asthma control outcomes, according to data presented at the American Academy of Pediatrics National Conference & Exhibition.
“Neither tobacco nor e-cigarette exposure is safe for children with asthma, so when we ask about smoking in the home, we need to ask about vaping too,” Brian Jenssen, MD, MSHP, associate professor of pediatrics at Children’s Hospital of Philadelphia, told Healio.
“Screening parents for both products at routine visits, and connecting them to treatment, is

A landscape assessment of more than 150 studies revealed reductions in circulating tumor DNA are associated with improved OS across solid cancer types, despite substantial heterogeneity in assays and collection and sampling timepoints.
“There’s a remarkably consistent signal across a diverse body of research,” Elena Levi-D’Ancona, PhD, science policy analyst at Friends of Cancer Research, told Healio. “There’s a strong signal here.”
Healio has reported on multiple studies in the past year detailing potential benefits of circulating tumor DNA (ctDNA) in several malignancies, including:
Clinicians

In 395,831 UK adults, the body roundness index predicted heart attacks slightly better than BMI. What the finding means and why the edge was small.

About 1 in 4 men with SCAD, a rare heart artery tear, reported lifting more than 50 pounds beforehand, compared with about 7% of women.

Doctors in India report scrub typhus that caused tetany as blood calcium and phosphate fell, a problem they say was probably driven by the kidneys.

A Ugandan crash survivor's infected thigh hid a 6-cm bone fragment near major vessels, likely from the rider who died. Her own femur was intact.