NEW ORLEANS — In this video, David Almeida, MD, MBA, PhD, discusses the safety, tolerability and pharmacodynamic signal of CG-P5, a topical peptide eye drop, in patients with wet age-related macular degeneration.
Almeida, of Erie Retina Research in Pennsylvania, said that up to 40% of patients being treated for wet AMD do not meet treatment expectations.
In a phase 1 study presented at the American Academy of Ophthalmology meeting, patients with treatment-experienced wet AMD were randomly assigned to receive CG-P5 (Caregen), Eylea (aflibercept 2 mg, Regeneron) or placebo for 84 days.

NEW ORLEANS — In this video, Jennifer I. Lim, MD, discusses phase 2 data on OCU410 presented at the American Academy of Ophthalmology meeting.
The trial evaluated OCU410 (Ocugen) subretinal gene therapy in patients with geographic atrophy. The one-time injection reduced the rate of ellipsoid zone loss by 27% and the rate of retinal pigment epithelium loss by 45%.
Lim called OCU410 a “promising potential new treatment” and noted that the phase 3 ArMaDa study of the therapy is ongoing.
Reference:

NEW ORLEANS — In this video from the American Academy of Ophthalmology meeting, Sunir J. Garg, MD, FACS, FASRS, discusses what has been learned from phase 3 data on two FDA-approved treatments for geographic atrophy.
Garg, of Wills Eye Hospital, noted that with pegcetacoplan, patients with nonsubfoveal geographic atrophy responded to treatment better that patients with subfoveal lesions. In addition, over time, both Syfovre (pegcetacoplan injection, Biogen) and Izervay (avacincaptad pegol intravitreal solution, Astellas) showed additive benefit of treatment at 12 months, 18 months and 24

After a broken foot, surgeries and a serious concussion threatened their season, Ellie Kam and Danny O'Shea used rehabilitation and gradual training to return and help Team USA win Olympic team-event gold.

Un estudio de Kaiser Permanente en 15.124 bebés a término no encontró diferencias estadísticamente significativas entre la vacuna materna contra el VRS y nirsevimab para prevenir infecciones u hospitalizaciones.

The FDA advises consumers and food businesses not to eat or serve Haifa Smoked Fish cold-smoked sprats after an inspection found inadequate safeguards against botulism.

Ultimate Forza Male Supplement capsules are being recalled after testing found undeclared sildenafil, tadalafil and dapoxetine, creating serious risks, especially for people taking nitrate heart medications.

Many Americans postpone retirement planning, wills, emergency savings, and debt management because of financial pressure, uncertainty, or anxiety, but smaller steps and clear deadlines can help them act.

More than 4,000 Brigham and Women's nurses rejected Mass General Brigham's final contract offer. A strike remains possible, but no new walkout has been scheduled.

German authorities arrested an 18-year-old in connection with the death of a Fort Wayne teen, following an investigation into alleged Discord-based manipulation and online coercion.