Medical organizations call for $48.7 billion of NIH funding

More than 140 U.S. medical organizations are advocating for the passage of a bill that would increase NIH funding for fiscal year 2026.
In a letter sent to the majority and minority leaders of the U.S. House of Representatives and U.S. Senate, 143 medical and scientific organizations called on Congress to pass an appropriations bill that would provide $48.7 billion of funding to the NIH in fiscal year 2026. The letter was released Jan. 20, the same day that the U.S. House Committee on Appropriations and the U.S. Senate Committee on Appropriations announced details on the bill.
“The undersigned

Insomnia plus sleep apnea raises uncontrolled hypertension odds

Middle-aged adults with comorbid insomnia and sleep apnea faced significantly elevated odds for uncontrolled hypertension vs. adults without these conditions, according to results published in Annals of the American Thoracic Society.
“These findings provide novel insights for identifying subgroups of OSA patients at risk of adverse cardiovascular consequences,” Mio Kobayashi Frisk, MD, doctoral student at the University of Gothenburg and resident physician at Sahlgrenska University Hospital, and colleagues wrote.
“Furthermore, our results underscore the importance of recognizing sleep health as

Penicillin allergy delabeling odds differ based on race

The likelihood for penicillin allergy delabeling was significantly reduced among Black and Asian patients vs. white patients, but this changed based on health system, according to data published in Annals of Allergy, Asthma & Immunology. 

“We appreciate the limitations of race and ethnicity as classifications, especially in electronic health records; however, we were surprised that race and ethnicity had variable associations depending on the hospital system,” Kimberly G. Blumenthal, MD, MSc, professor of medicine at Mayo Clinic College of Medicine and Science, and Alysse G. Wurcel,

Mental health disorders may increase risk for liver cancer

Mental health conditions such as alcohol use disorder and PTSD could significantly increase risk for liver cancer among individuals with cirrhosis.
An investigation of more than 220,000 veterans found those with any mental health disorder had a 65% higher risk for developing hepatocellular carcinoma.
The approval of direct-acting antivirals for hepatitis C virus substantially reduced the connection between mental health and HCC among veterans, but the association stayed significant as individuals with these disorders may have barriers to care.
“If we have a patient who has developed liver

Cost, safety temper enthusiasm for CAR T in rheumatology

Although rheumatologists consider chimeric antigen receptor T-cell therapy “potentially transformative,” nearly 70% remain hesitant on whether its efficacy outweighs the possible risks, according to survey data from Spherix Global Insights.
“We are standing at the threshold of major change in rheumatology,” Sawyer May, insights director of rheumatology at Spherix Global Insights, told Healio. “The survey data and clinical experience underscore genuine excitement about cell therapies’ potential to deliver drug-free remission — or even cure — for severe, refractory autoimmune diseases.”
Spherix

Can certain foods prevent stomach cancer?

Can what you eat help you avoid getting stomach cancer? "Most cases of stomach cancer happen sporadically and are purely a matter of bad luck," says Sharon Shiraga, MD, an upper-gastrointestinal surgeon with Keck Medicine of USC. While there is no magic bullet to avoid stomach cancer, your daily food choices, combined with other healthy lifestyle practices, may help lower your risk.

Neuronal activity reveals new clues to ALS progression

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no cure and limited treatment options. One of the earliest signs of ALS is overactive brain signals known as cortical hyperexcitability. This activity appears even before motor neurons begin to degenerate and physical symptoms such as trouble walking or swallowing show up. Now, Thomas Jefferson University researchers have discovered that neurons carrying the most common genetic cause of ALS respond abnormally to cortical hyperexcitability. The findings, published in the American Journal of Physiology-Cell Physiology, offer fresh insight into how the disease takes hold.

Rare cranial disorders: Towards a non-invasive therapy using gene silencing delivered by nanoparticles and 3D printing

A "gene silencer" (technically known as small interfering RNA, or siRNA), locally delivered by nanoparticles embedded in an injectable gel produced through 3D printing, can switch off the defective gene responsible for serious rare diseases known as craniosynostoses. These conditions are characterized by malformations of the skull and are currently treatable only through highly invasive surgical procedures performed in newborns and often repeated throughout childhood.