Phase 2 lunsekimig studies in asthma, CRSwNP ‘step forward’

The IL-13/thymic stromal lymphopoietin nanobody compound lunsekimig has shown promise in treating moderate to severe asthma and chronic rhinosinusitis with nasal polyps in phase 2 studies, according to a press release from Sanofi.
The release highlighted that the primary endpoint and key secondary endpoints of these studies were met with lunsekimig (Sanofi) vs. placebo in the above patient populations.
Lunsekimig has also been examined in moderate to severe atopic dermatitis, but the primary endpoint was not met in its phase 2 study, according to the release.
Healio spoke with Alyssa Johnsen,

Most patients with pancreatic cancer not offered clinical trials

Most patients with pancreatic cancer report they were never offered the opportunity to participate in clinical trials.
A survey of more than 1,000 patients showed greater than 70% never received an offer to enroll, and significant disparities exist among those who did, with higher odds of a trial offer for patients treated at academic institutions or diagnosed with stage IV disease.
“There’s no progress without clinical trials,” Udhayvir S. Grewal, MD, assistant professor in the department of hematology and medical oncology at Winship Cancer Institute at Emory University, told Healio.
“If you

Dietary fats shape pancreatic cancer risk via ferroptosis

For decades, the relationship between fat and cancer has been treated as a question of quantity: Eat less fat, reduce your risk of developing cancer. But new research published April 29 in Cancer Discovery shows that for pancreatic cancer, the type of fat you consume matters more than the amount.

Battery-free skin-conformal wearable system can measure electrocardiogram signals

A research team led by Prof. Jerald Yoo from the Department of Electrical and Computer Engineering at Seoul National University (SNU) has developed a skin-conformal wearable health care system, "SkinECG," capable of measuring electrocardiogram (ECG) signals without a battery. By combining energy harvesting with human body–coupled power transfer, the study presents a new solution to one of the most critical challenges in wearable devices: power supply.

Early brain regions play greater role in decision-making, challenging traditional neuroscience

New insight into decision-making pathways in the brain may impact the way engineers think about artificial intelligence, according to new research from The Grainger College of Engineering at the University of Illinois Urbana-Champaign. Led by electrical and computer engineering professor Yurii Vlasov and published in Proceedings of the National Academy of Science, the group's findings highlight the involvement of early brain regions in decision-making, challenging long-held assumptions about brain hierarchy.

Skull microchannels reveal hidden route for brain immune defense

A study led by Rafael Gallareto-Sande, a predoctoral researcher at the Centro Nacional de Investigación sobre la Evolución Humana (CENIEH), provides new insights into a network of tiny blood vessels within the cranial bones that play a key role in brain protection. The research, published in The Anatomical Record, reports for the first time the number and size of these microscopic channels, known as vascular microforamina, which connect the cranial bone with the intracranial space.

Faster and easier ways to diagnose Mpox: New approaches improve detection

Following the rise in Mpox cases, particularly in countries where the disease had not traditionally been observed, the World Health Organization (WHO) declared a Public Health Emergency of International Concern in June 2022 and again in August 2024. Accurate and timely diagnosis plays a critical role in controlling the infection. However, PCR-based methods—the gold standard for Mpox diagnosis—require complex laboratory infrastructure and trained personnel, making them less accessible in many settings. For this reason, the development of point-of-care diagnostic tools is of great importance.