Cell-free DNA offers early warning for bloodstream infections in kids with leukemia

Researchers have identified a promising way to predict bloodstream infections in children with high-risk leukemia days before the infection would be diagnosed using current standards of care. The test, named plasma microbial cell-free DNA sequencing (mcfDNA-Seq), detected infection-causing pathogens days before standard blood cultures, offering a potential approach to protecting vulnerable patients by allowing treatment to start before the patient gets sick. The study is published in The Lancet Microbe.

FDA is removing the ‘black box’ warning on hormone treatments for women in menopause

For years, Cathleen "Cat" Brown, a Philadelphia obstetrician and gynecologist, would listen to patients complaining of hot flashes, brain fog, and painful sex and prescribe estrogen as a safe option for easing their menopausal symptoms. But when the women read the drug label and pharmacy package insert, they'd recoil at a "black box" warning, Brown said. The bold, black-bordered alert warned women that estrogen may put them at higher risk of breast cancer, cardiovascular disease, stroke, and dementia.

AI analysis finds no clear brain-structure link to navigation in young adults

Steven Weisberg, a researcher at the University of Texas at Arlington, found that advanced artificial intelligence tools could not uncover a clear link between brain structure and navigation ability in healthy young adults—challenging long-standing ideas about how the brain helps us find our way. For decades, many in the scientific community believed that people with elite navigation skills—such as quickly learning and recalling complex routes—might have larger or differently shaped brain regions than others. Famous studies of London taxi drivers, for example, suggested that intense navigation training could lead to more "real estate" in certain parts of the brain.

Improve education and transitional support for autistic people to prevent death by suicide, say experts

Suicide in autistic people originates in the inequalities they face across their lives, starting in childhood, and spanning education to employment, and health and social care, a new study by a team at Cambridge and Bournemouth Universities has found. The researchers call for a radical change in the way society understands suicide and mental illness in autistic people, who are three to five times more likely to die by suicide.

Breast cancer still most common cancer among women worldwide, with annual cases expected to exceed 3.5 million by 2050

Despite recent advancements in breast cancer treatments, new breast cancer cases in women are predicted to rise by a third globally from 2.3 million in 2023 to more than 3.5 million in 2050. Similarly, yearly deaths from the disease are projected to surge 44%, from around 764,000 to 1.4 million, with disproportionate impact in countries with limited resources, according to a major new analysis from the Global Burden of Disease Study Breast Cancer Collaborators, published in The Lancet Oncology.