Protein clues may help explain heart disease risk that persists despite lower LDL cholesterol

According to the World Health Organization (WHO), nearly 17.9 million people die from cardiovascular diseases worldwide every year, with heart attacks and strokes accounting for more than four out of five of those deaths. Coronary heart disease, which can lead to a heart attack if untreated, develops when fatty material (cholesterol) accumulates in the blood vessels supplying the heart. High blood cholesterol is therefore a key risk factor for coronary heart disease.

Prime editing repairs immune disorder defect in patient’s own blood stem cells

Some people are born with a defect in their genetic material that prevents their immune system from functioning properly. In people with a condition known as GATA2 deficiency, the body does not produce enough immune cells, leaving them at increased risk of infections and disease. Now, researchers at Aarhus University have demonstrated that they can repair the genetic defect directly in patients' own blood stem cells.

Kidney biopsy maps reveal immune clusters that may keep inflammation going

Acute interstitial nephritis (AIN) is a condition characterized by inflammation that damages the kidney's tubules and surrounding tissue. Often resulting from an immune reaction to common medications—including antibiotics, anti-inflammatory medications and drugs that treat acid reflux—the condition accounts for roughly 15% to 20% of biopsied cases of acute kidney injury (AKI), defined as a sudden decline in kidney function.

Alzheimer’s blood biomarker tracks brain amyloid similarly across racial groups, study finds

A large global study provides new evidence supporting the use of blood biomarkers in an Alzheimer's clinical trial to screen for elevated brain amyloid levels among potential participants who are cognitively unimpaired. The findings, published in JAMA Neurology, show that the relationship between blood biomarker levels and brain amyloid was largely similar across racial groups.