Rheumatoid arthritis may have causal relationship on gout risk

Rheumatoid arthritis, specifically seronegative RA, demonstrates a causal effect on increasing gout risk, which may suggest a level of epidemiological association, genetic causality or intersecting molecular features, according to data.
“For decades, the coexistence of RA and gout has been contentious, with early hypotheses suggesting limited overlap — such as rheumatoid factor masking urate crystals or hyperuricemia modulating inflammation,” Shaowei Li, of Guangzhou University of Chinese Medicine in China, and colleagues wrote in Arthritis Research & Therapy.
“Additionally,

Study compiles 30 years of adhesion GPCR modulators and their key concentrations

Adhesion GPCRs are a large class of surface proteins that recognize chemical and mechanical stimuli in the body. The rapidly expanding body of knowledge on the therapeutic targeting of these receptors is raising hopes for clinical application in the near future. Although no medicinal products targeting these receptors have yet been approved, several adhesion GPCR modulators are available and show potential for translation into clinical use. Modulators are crucial for the regulation of metabolic pathways and play a major role in pharmacology by enabling the targeted control of receptor activity.