Dupilumab shows benefits in EoE not meeting approval thresholds

Among infants with eosinophilic esophagitis aged younger than 1 year or weighing less than 15 kg, esophageal eosinophilia and growth improved after starting dupilumab, according to study results.
In children with EoE, dupilumab (Dupixent; Regeneron, Sanofi) is FDA approved for use in those aged 1 to 11 years who weigh at least 15 kg.
“Our findings suggest that dupilumab may be a promising treatment option for infants with eosinophilic esophagitis who have limited therapeutic choices,” Sasha-Jane Abi Aad, MD, MSc, postdoctoral research fellow at University of South Florida, told Healio.
“While

Noninvasive testing, AI set to refine colorectal cancer screening

Updated American Cancer Society guidance is reshaping colorectal cancer screening, expanding testing options and raising questions about where noninvasive tests, AI and risk-based screening fit alongside established approaches.
In its recently revised screening guidance, the American Cancer Society (ACS) included two new at-home stool tests and added a limited recommendation for blood-based screening for patients who decline other forms of screening.
The update has sparked concern from ACG, which warned that the new blood-based test guidelines could confuse patients and undermine adherence to

Rates of opioid toxicity deaths highest among construction and trades workers, study finds

Between 2018 and 2024, those who worked in construction and trades made up approximately one-third of deaths from opioid toxicity in Ontario where occupation was known, according to a report released this week by the Ontario Drug Policy Research Network (ODPRN). In addition to highlighting the toll of opioid toxicities in this sector, the report also draws attention to their impact among people across various occupations.

Licensed Zaire Ebola vaccine may offer partial protection against Bundibugyo outbreak

Ebolaviruses are among the most dangerous known human pathogens. Three ebolavirus species have repeatedly caused major disease outbreaks on the African continent. Most outbreaks have been caused by Zaire ebolavirus. Vaccines and therapeutics are available for this virus species. In contrast, no therapeutics or vaccines are currently available against Bundibugyo ebolavirus, which is responsible for the ongoing outbreak in the Democratic Republic of the Congo and Uganda. This significantly complicates efforts to control the outbreak, which is already the largest documented Bundibugyo ebolavirus outbreak to date.

Your gut can get jet lag too: How not to waste the first days of your vacation

A dream vacation, an exotic destination, a long-haul flight and finally some well-deserved rest. The problem is that many travelers arrive at their destination only to spend the first days of their vacation struggling with fatigue, sleep disturbances, low energy levels and digestive issues. Researchers from Wroclaw Medical University point out that these symptoms may be caused by more than classic jet lag. A growing body of evidence suggests that time zone changes also affect the trillions of bacteria living in our intestines.