Pregnancy does not appear to affect autosomal dominant polycystic kidney disease progression, according to study data published in the Journal of the American Society of Nephrology.
Previous studies exploring an association between pregnancy and autosomal dominant PKD (ADPKD) have provided “inconclusive” results, according to Stephanie Lapierre-Nguyen, PhD, postdoctoral fellow at University of Colorado Anschutz Medical Campus, and colleagues. Because patients with ADPKD have a higher likelihood to progress to end-stage kidney disease later in life, the researchers aimed to evaluate

Among parents of children/adolescents with food allergy, strict allergen avoidance practices and oral food challenge history were linked to higher psychosocial burden, according to data published in Annals of Allergy, Asthma & Immunology.
“Multiple factors interact to determine the [quality of life] of children with [food allergy] and their parents,” Stephanie A. Kubala, MD, attending physician in the division of allergy and immunology at Children’s Hospital of Philadelphia, and colleagues wrote. “While many of these factors are the same, attention to those unique to the child and to the

Children with type 1 diabetes had similar long-term glycemic outcomes with two different automated insulin delivery systems, researchers reported in a paper published in Diabetes Technology & Therapeutics.
In a single-center study conducted at UPMC Children’s Hospital of Pittsburgh, researchers compared data between children with type 1 diabetes using the Omnipod 5 (Insulet) and those using Control-IQ (Tandem Diabetes Care) over 18 months. Both systems conferred similar improvements in continuous glucose monitoring metrics, but there were differences in how participants used each system.

Results presented at the Pediatric Orthopaedic Society of North America Annual Meeting showed excessive anterior pelvic tilt was not significantly associated with back pain in adults with cerebral palsy.
“We probably do not need to be worried about anterior pelvic tilt as much when we are trying to make decisions for adolescent care, particularly hamstring lengthening,” M. Wade Shrader, MD, vice chair in the department of orthopedic surgery and division chief of Nemours Children’s Health Cerebral Palsy Center, told Healio. “Hamstring lengthening has been a mainstay in

ORLANDO — Compared with the current standard of care for patients with alpha-1 antitrypsin deficiency-related emphysema, investigational efdoralprin alfa showed better outcomes and similar safety, according to data presented here.
This investigational therapy from Sanofi “is a recombinant human [alpha-1 antitrypsin-fragment crystallizable] fusion protein,” according to a company press release on the data presented at the American Thoracic Society International Conference.
“Our investigators are excited about the results because we provide a solution that is less burdensome for patients, but

Patients with pancreatic cancer who have “ultra-low baseline values” of a biomarker used for prognosis have similar survival as those who have the highest levels and are considered to have the worst outcomes.
A dual-threshold model found PFS and OS did not differ for patients who had cancer antigen 19-9 (CA19-9) levels less than 7 U/mL or greater than 200 U/mL.
“Pay attention to ultra-low baseline values,” Yung-Yeh Su, MD, PhD, attending physician at National Health Research Institutes in Taiwan, told Healio.
“A serum CA19-9 value of less than 7 U/mL should be flagged as a surrogate marker for a

Individuals with hepatic steatosis appeared to have higher amounts of noncalcified coronary plaque and were almost twice as likely to experience major adverse cardiovascular events compared with those without fatty liver disease, data show.
Noncalcified plaque, which is lipid rich and susceptible to rupture that can lead to blood clots, accounted for approximately 11% of this elevated risk. The raised risk suggests that plaque burden is an important contributor, but that additional pathways also are likely involved.
“In hepatic steatosis, the cardiovascular risk is carried not only by how much

Early and aggressive intervention is recommended for children with juvenile idiopathic arthritis, according to new 2026 guidelines from the American College of Rheumatology.
“If a child has damage from untreated or undertreated arthritis, that will follow them forever,” Karen Onel, MD, chief of the division of pediatric rheumatology at the Hospital for Special Surgery, and professor of clinical pediatrics at Weill Cornell Medicine, told Healio. “We know that some children with get off medication over time as the arthritis regresses. However, if damage has already happened