Adults with pulmonary hypertension associated with interstitial lung disease receiving once-daily inhaled mosliciguat had a larger decrease in pulmonary vascular resistance at week 16 vs. placebo, according to phase 2 trial topline data.
These findings on mosliciguat (Roivant, Pulmovant), a potential first-in-class sGC activator, were simultaneously presented at the European Respiratory Society International Congress.
“Mosliciguat demonstrated improvements across multiple clinically relevant domains, including hemodynamics, exercise capacity and biomarkers of right ventricular strain,” Parth M.

Four years after Ultra Low Emission Zone implementation in London, lung function growth trajectories of school-aged children improved and nitrogen dioxide exposure fell, according to data published in The Lancet Public Health.
“Clinicians should be aware of the effects of air pollution exposure on children’s health, namely increased risk of respiratory infections, asthma and worse asthma symptoms, and consider air pollution as a potential contributing factor if they see children repeatedly presenting with these issues,” Helen E. Wood, DPhil, research fellow at the Wolfson Institute of

Early-onset colorectal cancer with liver-only metastases can have significant differences in biology from late-onset malignancies.
A study of nearly 1,700 individuals from Australia showed early-onset disease occurred more often in women, and patients had higher rates of BRAF mutations and left-sided cancers.
Additionally, those with early-onset disease had better functional status, fewer comorbidities and significantly longer survival.
“These [biological differences] likely impact the behavior of the cancer and, hence, response to treatments,” Savio G. Barreto, FRACS, PhD, professor of surgery

The Vaccine Handbook : A Practical Guide for Clinicians by Gary S. Marshall, MD, is now accessible through Healio Clinical Guidance, offering healthcare professionals expert-backed vaccine guidance.
“Healio and The Vaccine Handbook put reliable vaccine information directly in front of clinicians, helping them quickly access the evidence, recommendations and practical context they need to support informed conversations and decisions,” Brien Cummings, Vice President of Clinical Guidance, said in a press release.
[Editor’s note: The handbook is available here .]
Healio Clinical Guidance is a

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