Local factors linked to shorter breast cancer survival

Researchers developed an analytic framework that linked housing cost and density, recent relocation and the number of children enrolled in public preschools to shorter breast cancer survival.
According to Joseph Boyle, PhD, a research instructor in the department of family medicine and population health at Virginia Commonwealth University, and colleagues, a growing body of evidence links neighborhood-level socioeconomic factors to cancer outcomes. Notably, they cited studies that found individuals in neighborhoods that rank highly on the Area Deprivation Index had a greater risk for adverse

FDA’s move away from animal testing is ‘scientifically necessary’

The FDA’s recent announcement to reduce, and in some cases replace, animal testing for monoclonal antibodies and other therapeutics represents one of the most consequential regulatory developments in drug development in decades.
If implemented effectively, it will reshape how new biologic medicines reach patients and how regulators evaluate safety in the era of precision therapeutics. For clinicians, the shift has direct implications for how the safety and predictability of emerging biologic therapies will be assessed before they reach the clinic.
Although widely described as a “paradigm

Impact of Japan’s indoor smoke-free laws on the prevalence of smoke-free establishments

A multi-institutional research team in Japan evaluated the impact of the Revised Health Promotion Law and related local ordinances on indoor smoking policies in restaurants and bars. Their analysis identified a modest but significant increase in the proportion of smoke-free establishments following the full enforcement of the national indoor smoking ban in April 2020. Additional increases were observed in jurisdictions covered by stronger passive smoking prevention ordinances implemented by the Tokyo Metropolitan Government and Chiba City. The research is published in the journal Public Health.

Nearly 30 million Americans bought guns after the pandemic, with 11 million becoming first-time gun owners

A national survey estimates that nearly 30 million U.S. adults acquired firearms between 2021 and 2024, including more than 11 million people who became gun owners for the first time. These new owners also introduced guns into millions of households that previously had none, newly exposing about 9 million adults and 6.6 million children to firearms in their homes. These findings are published in the Annals of Internal Medicine.

New hypertension guideline does not recommend routine treatment for all adults over 65

An analysis of the 2025 AHA/ACC hypertension guidelines found that under the new guidelines, about 11% of adults ages 65 to 79 with stage I hypertension would no longer qualify for blood pressure medication, a major shift from previous rules that recommended treatment for all adults in this age range. The newly exempt group is made up of generally healthy, lower-risk older adults whose predicted 10-year cardiovascular risk falls below the new treatment threshold. The analysis is published in the Annals of Internal Medicine.

Postpartum Medicaid extensions reduce uninsured status

Postpartum uninsurance declined among Black women in non-expansion states during the COVID-19 continuous Medicaid coverage policy, but racial gaps persisted, according to a new study at Columbia University Mailman School of Public Health. The research is the first to explicitly examine how the policy affected racial equity in postpartum insurance coverage while also considering states' Medicaid expansion status under the Affordable Care Act (ACA). The study is published in the American Journal of Preventive Medicine.

GLP-1 drugs and pregnancy: Who may face higher preterm birth risk

Weight loss drugs have been linked to an increased risk of premature births among women who took them inadvertently just before or during early pregnancy to treat pre-existing diabetes. However, a large study of over 750,000 pregnancies found that there was no link to preterm births or other obstetric complications if the medication was being used to lose weight. The authors of the study, published in Human Reproduction Open, say their findings suggest that it is diabetes rather than the drugs that may be contributing to the increased risk of preterm births.

Osteoporosis drugs may cut dementia risk by 16%, study of 120,000 finds

A research team from the Department of Pharmacology and Pharmacy, LKS Faculty of Medicine of the University of Hong Kong (HKUMed), has found that nitrogen-containing bisphosphonates (NBPs), a medication widely used in the treatment of osteoporosis, may significantly reduce the risk of Alzheimer's disease and related dementias (ADRD) in older adults with osteoporosis or fragility fractures. This drug repurposing approach offers a promising avenue for the prevention of ADRD, potentially alleviating the global burden of these conditions. The research findings are published in Alzheimer's & Dementia.