Lab-grown retina gives gene change clue to rare childhood eye condition

A study using tiny retinas grown in a lab has revealed how subtle changes in a key growth-controlling protein can lead to a condition causing serious eye defects from birth. The findings, published in the journal Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease, shed new light on ocular coloboma, a rare congenital eye condition affecting about 1 in 5,000 births and responsible for roughly 10% of childhood blindness. Coloboma arises when a structure in the developing eye, the optic fissure, fails to close properly and often co-occurs with other tissue-fusion problems such as cleft lip and/or palate.

Low-frequency wireless sensor tracks artery stiffening in real time with less interference

Wireless sensors used in wearable smart devices and medical equipment must be capable of detecting minute changes while maintaining high operational stability. However, existing technologies often utilize excessively high frequencies, leading to electromagnetic interference (EMI) or potential health risks to the human body. To address these fundamental issues, a Korean research team has developed a low-frequency-based wireless sensor technology.

Common, treatable ear conditions are linked to higher odds of dementia; treatment may help

A recent study published in Otolaryngology–Head and Neck Surgery finds that two common and treatable causes of conductive hearing loss—eardrum perforations and cholesteatoma, a type of abnormal skin growth in the middle ear—are associated with higher odds of dementia. Notably, the study also found that treatment, whether through surgery or hearing aids, was associated with a reduction in that elevated risk.

Pain-sensing neurons mapped in unprecedented detail, pointing to new chronic pain drug targets

One in five people worldwide suffers from chronic inflammatory pain. Meanwhile, about two thirds of those affected find little relief from existing pain medications; new therapeutic approaches are urgently needed. "We first must understand precisely how sensory nerve cells trigger pain at the molecular level—in other words, which proteins are involved," says Professor Gary Lewin, Group Leader of the Molecular Physiology of Somatosensory Perception lab at the Max Delbrück Center in Berlin.

PICALM links training and intermittent fasting to new muscle fiber formation

Researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) and other partner institutions of the German Center for Diabetes Research (DZD) have now identified a previously unknown function of the PICALM protein in skeletal muscle: The protein responds sensitively to physical activity and intermittent fasting. It also plays a decisive role in the formation of new muscle fibers.

Why some vaccine side effects may be avoidable without weakening protection

Vaccines play a critical role in preventing infectious diseases, but their success often depends on adjuvants—substances that enhance immune responses. While these compounds improve vaccine effectiveness, they can also trigger reactogenicity, such as local swelling or fever. For decades, scientists have assumed that these beneficial and adverse effects are closely linked, making it difficult to improve one without affecting the other.