Tinnitus linked to depression, anxiety in dose-response manner

Chronic tinnitus is independently associated with depression and anxiety symptoms, according to a study published online in Neuropsychiatric Disease and Treatment. Enes Sırma, from University of Health Sciences Gazi Yasargil Training and Research Hospital in Diyarbakır, Turkey, and colleagues estimated the prevalence of mood symptoms among adults with chronic tinnitus, as well as whether tinnitus severity contributes to psychological burden.

Regional residents walk 75 minutes more weekly in highly walkable areas, study finds

New research published today shows that regional residents living in walkable towns and centers walk 75 minutes more each week, prompting calls for Governments to invest more in well-connected, safe footpaths to boost community health. The new paper, led by the Menzies Institute for Medical Research at the University of Tasmania, was published today in the Australia and New Zealand Journal of Public Health. It's the first of its kind to show walkability has a bigger impact on the amount of time spent walking in regional communities.

Trial shows angioplasty reduces chest pain, boosts QoL in chronic total occlusion

In what is believed to be the first randomized placebo-controlled trial of its kind, patients with a chronic total blockage of a coronary artery who received a nonsurgical procedure to reopen the artery showed statistically significant reductions in chest pain and improvements in quality of life compared with patients who received a placebo procedure. The research was presented at the American College of Cardiology's Annual Scientific Session (ACC.26). The study was simultaneously published online in the JACC.

Study finds 10-plus genetic markers tied to early follicular lymphoma relapse

Follicular lymphoma (FL) is a type of blood cancer and a form of non-Hodgkin's lymphoma. Thanks to new treatment breakthroughs, about 80% of FL patients have a survival rate of more than 10 years. The other 20%, however, experience a quickly recurring or a more aggressive version. Now researchers from the University of Missouri School of Medicine may have found a way to identify the patients at risk of recurrence, without the need for imaging and surveillance testing. Their paper is published in the American Journal of Clinical Oncology.

Half of Medicaid beneficiaries could lose coverage if work requirements are extended nationally

A cross-sectional study suggests that if Congress were to impose Medicaid work requirements across the country, roughly half of adult enrollees could be at risk of losing coverage despite having higher rates of physical, cognitive, and daily-living impairments. Researchers found that many of these adults report poor overall health, even though their impairments may not qualify them for formal disability exemptions. The study is published in Annals of Internal Medicine.

Cysteine pathways help T cells choose between multiplying and attacking tumors

A research team from the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health has discovered how the immune system's CD8+ T cells use the nutrient cysteine to control two essential functions that compete for this resource—the immune cell's ability to multiply and its ability to kill cancer cells.

Study finds no significant benefit of spironolactone in HFpEF or HFmrEF

A trial testing the aldosterone blocker spironolactone in patients with heart failure with preserved ejection fraction (HFpEF) and heart failure with mildly reduced ejection fraction (HFmrEF) did not show any significant improvement in terms of heart failure hospitalizations and cardiovascular death at 24 months, according to findings presented at the American College of Cardiology's Annual Scientific Session (ACC.26).