Developing a human hepatocyte model with enhanced drug-metabolizing enzyme activity

A research team led by Associate Professor Shinpei Yamaguchi and the late Professor Masako Tada of the Faculty of Science, together with Professor Yojiro Anzai and Lecturer Yohei Iizaka of the Faculty of Pharmaceutical Sciences at Toho University, have developed a new HepaRG cell line with markedly enhanced activity of CYP2D6, a major drug-metabolizing enzyme. This engineered human hepatocyte model enables more human-relevant evaluation of drug-induced hepatotoxicity mediated by CYP2D6. The study was published in the journal PLOS ONE on December 29, 2025.

One-question screen may flag hoarding in Alzheimer’s and other dementias

Researchers at the University of Colorado Anschutz have developed a simple, one-question screening tool that could help doctors quickly identify hoarding behaviors in patients with memory loss and other brain disorders. Early detection, they said, could lead to early intervention, helping to reduce safety risks, relieve caregiver stress and improve the quality of life for both patients and families.

Infographics about healthy eating can spark interest among unmotivated young adults, study finds

Young adults who are not motivated to eat healthily can still be engaged with the right type of communication, according to new research from the European Food Information Council (EUFIC). Young adults often face unique dietary challenges, from limited resources and time constraints to social and emotional barriers to healthy eating. The study, "Healthy Eating for Young Adults: Communication in Early Stages of Behaviour Change," published in the Journal of Nutrition Education and Behavior, explored how 18- to 25-year-olds in the U.K. respond to infographics about healthy eating designed for those not yet committed to changing their diets.

Predicting cardiovascular complications in chronic kidney disease using microRNAs in blood

Tiny RNA molecules carried by extracellular vesicles in the bloodstream can accurately predict kidney function decline and cardiovascular risk in chronic kidney disease (CKD), as reported by researchers from Science Tokyo. By analyzing blood samples from a large cohort, the team identified multiple microRNAs linked to disease progression and built a model to distinguish high-risk patients with CKD. Clinically applying this risk score model can contribute to improved patient outcomes.

Ketamine reduces anxiety and social withdrawal in stressed adolescent mice

Ketamine is a powerful anesthetic used for surgery and acute pain management. But in recent years, it has also gained a reputation as a potential treatment for certain mental health conditions like stress and anxiety. In a new study published in the journal Physiology & Behavior, scientists suggest another possible use for ketamine as a protective shield for the brain during turbulent adolescent years.